Determination of the gene order of the three loci CD2, NGFB, and NRAS at human chromosome band 1p13 and refinement of their localisation at the subband level by fluorescence in situ hybridisation.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97946
Title:
Determination of the gene order of the three loci CD2, NGFB, and NRAS at human chromosome band 1p13 and refinement of their localisation at the subband level by fluorescence in situ hybridisation.
Authors:
Mitchell, Erika L D; Jones, D; White, Gavin R M; Varley, Jennifer; Santibanez-Koref, Mauro F
Abstract:
The three loci NRAS, NGFB, and CD2 map to human chromosome band 1p13. Using fluorescence in situ hybridisation (FISH) to simultaneously DAPI-banded metaphase chromosomes, we have further refined the localisation of these three genes to specific subbands. NRAS localises to subband 1p13.2 and CD2 and NGFB to 1p13.1. Also, with the use of multicolour FISH, we have determined the order and orientation of the three loci in relation to the centromere. The order is cen-CD2-NGFB-NRAS.
Affiliation:
Cancer Research Campaign Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Determination of the gene order of the three loci CD2, NGFB, and NRAS at human chromosome band 1p13 and refinement of their localisation at the subband level by fluorescence in situ hybridisation. 1995, 70 (3-4):183-5 Cytogenet. Cell Genet.
Journal:
Cytogenetics and Cell Genetics
Issue Date:
1995
URI:
http://hdl.handle.net/10541/97946
DOI:
10.1159/000134028
PubMed ID:
7789166
Type:
Article
Language:
en
ISSN:
0301-0171
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMitchell, Erika L Den
dc.contributor.authorJones, Den
dc.contributor.authorWhite, Gavin R Men
dc.contributor.authorVarley, Jenniferen
dc.contributor.authorSantibanez-Koref, Mauro Fen
dc.date.accessioned2010-05-05T12:38:26Z-
dc.date.available2010-05-05T12:38:26Z-
dc.date.issued1995-
dc.identifier.citationDetermination of the gene order of the three loci CD2, NGFB, and NRAS at human chromosome band 1p13 and refinement of their localisation at the subband level by fluorescence in situ hybridisation. 1995, 70 (3-4):183-5 Cytogenet. Cell Genet.en
dc.identifier.issn0301-0171-
dc.identifier.pmid7789166-
dc.identifier.doi10.1159/000134028-
dc.identifier.urihttp://hdl.handle.net/10541/97946-
dc.description.abstractThe three loci NRAS, NGFB, and CD2 map to human chromosome band 1p13. Using fluorescence in situ hybridisation (FISH) to simultaneously DAPI-banded metaphase chromosomes, we have further refined the localisation of these three genes to specific subbands. NRAS localises to subband 1p13.2 and CD2 and NGFB to 1p13.1. Also, with the use of multicolour FISH, we have determined the order and orientation of the three loci in relation to the centromere. The order is cen-CD2-NGFB-NRAS.en
dc.language.isoenen
dc.subject.meshAntigens, CD-
dc.subject.meshAntigens, CD2-
dc.subject.meshBase Sequence-
dc.subject.meshCell Nucleus-
dc.subject.meshChromosome Mapping-
dc.subject.meshChromosomes, Artificial, Yeast-
dc.subject.meshChromosomes, Human, Pair 1-
dc.subject.meshDNA Primers-
dc.subject.meshExons-
dc.subject.meshGenes, ras-
dc.subject.meshHumans-
dc.subject.meshIn Situ Hybridization, Fluorescence-
dc.subject.meshInterphase-
dc.subject.meshMale-
dc.subject.meshMetaphase-
dc.subject.meshMolecular Sequence Data-
dc.subject.meshNerve Growth Factors-
dc.subject.meshOligonucleotide Probes-
dc.subject.meshPolymerase Chain Reaction-
dc.titleDetermination of the gene order of the three loci CD2, NGFB, and NRAS at human chromosome band 1p13 and refinement of their localisation at the subband level by fluorescence in situ hybridisation.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalCytogenetics and Cell Geneticsen

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