2.50
Hdl Handle:
http://hdl.handle.net/10541/97944
Title:
Mapping of gene loci in the Q13-Q15 region of chromosome 12.
Authors:
Mitchell, Erika L D; White, Gavin R M; Santibanez-Koref, Mauro F; Varley, Jennifer; Heighway, Jim
Abstract:
The gene loci CDK4, GLI, CHOP and MDM2 have been mapped to the q13-q15 region of chromosome 12. Using fluorescence in situ hybridization onto simultaneously DAPI-banded metaphase chromosomes and interphase nuclei, we have more precisely mapped and ordered these loci, together with a number of Genethon microsatellite markers. GLI and CHOP localize to 12q13.3-14.1, CDK4 to 12q14 and MDM2 to 12q14.3-q15, and the gene order is cen-GLI/CHOP-CDK4-MDM2. The Genethon microsatellites D12S80 and D12S83 flank MDM2.
Affiliation:
Cancer Research Campaign Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester.
Citation:
Mapping of gene loci in the Q13-Q15 region of chromosome 12. 1995, 3 (4):261-2 Chromosome Res.
Journal:
Chromosome Research
Issue Date:
Jun-1995
URI:
http://hdl.handle.net/10541/97944
DOI:
10.1007/BF00713052
PubMed ID:
7606365
Type:
Article
Language:
en
ISSN:
0967-3849
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMitchell, Erika L Den
dc.contributor.authorWhite, Gavin R Men
dc.contributor.authorSantibanez-Koref, Mauro Fen
dc.contributor.authorVarley, Jenniferen
dc.contributor.authorHeighway, Jimen
dc.date.accessioned2010-05-05T12:28:08Z-
dc.date.available2010-05-05T12:28:08Z-
dc.date.issued1995-06-
dc.identifier.citationMapping of gene loci in the Q13-Q15 region of chromosome 12. 1995, 3 (4):261-2 Chromosome Res.en
dc.identifier.issn0967-3849-
dc.identifier.pmid7606365-
dc.identifier.doi10.1007/BF00713052-
dc.identifier.urihttp://hdl.handle.net/10541/97944-
dc.description.abstractThe gene loci CDK4, GLI, CHOP and MDM2 have been mapped to the q13-q15 region of chromosome 12. Using fluorescence in situ hybridization onto simultaneously DAPI-banded metaphase chromosomes and interphase nuclei, we have more precisely mapped and ordered these loci, together with a number of Genethon microsatellite markers. GLI and CHOP localize to 12q13.3-14.1, CDK4 to 12q14 and MDM2 to 12q14.3-q15, and the gene order is cen-GLI/CHOP-CDK4-MDM2. The Genethon microsatellites D12S80 and D12S83 flank MDM2.en
dc.language.isoenen
dc.subject.meshCCAAT-Enhancer-Binding Proteins-
dc.subject.meshChromosome Mapping-
dc.subject.meshChromosomes, Human, Pair 12-
dc.subject.meshCyclin-Dependent Kinase 4-
dc.subject.meshCyclin-Dependent Kinases-
dc.subject.meshDNA-Binding Proteins-
dc.subject.meshGenetic Markers-
dc.subject.meshHumans-
dc.subject.meshIn Situ Hybridization, Fluorescence-
dc.subject.meshNuclear Proteins-
dc.subject.meshOncogene Proteins-
dc.subject.meshProtein-Serine-Threonine Kinases-
dc.subject.meshProto-Oncogene Proteins-
dc.subject.meshProto-Oncogene Proteins c-mdm2-
dc.subject.meshTrans-Activators-
dc.subject.meshTranscription Factor CHOP-
dc.subject.meshTranscription Factors-
dc.titleMapping of gene loci in the Q13-Q15 region of chromosome 12.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester.en
dc.identifier.journalChromosome Researchen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.