2.50
Hdl Handle:
http://hdl.handle.net/10541/97941
Title:
Effects of IL-11 on the growth of intestinal epithelial cells in vitro.
Authors:
Booth, Catherine; Potten, Christopher S
Abstract:
The network of interacting factors that control proliferation in the intestinal epithelium is largely unknown. Recently, IL-11 was found to protect animals from lethal doses of cytotoxic agents. Part of this protective action was ascribed to a reduced level of damage in the intestinal epithelium. Whether this was due to a direct effect on epithelial cell cycle progression was unclear. We have addressed this question in vitro and found that IL-11 reversibly inhibited proliferation in untransformed small intestinal IEC18 cells. However, IL-11 did not inhibit transformed SW620 or HT29 colonic cell lines. IL-6 behaved in a similar manner to IL-11. Thus, these results suggest that IL-11 may be an ideal therapy adjuvant, protecting normal cells and further, these results suggest that IL-11 may be involved in the normal growth controls in the intestinal epithelium. The inhibitory response evoked by IL-11 is lost during carcinogenic transformation.
Affiliation:
CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Withington, Manchester, UK.
Citation:
Effects of IL-11 on the growth of intestinal epithelial cells in vitro. 1995, 28 (11):581-94 Cell Prolif.
Journal:
Cell Proliferation
Issue Date:
Nov-1995
URI:
http://hdl.handle.net/10541/97941
DOI:
10.1111/j.1365-2184.1995.tb00046.x
PubMed ID:
8555371
Type:
Article
Language:
en
ISSN:
0960-7722
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorBooth, Catherineen
dc.contributor.authorPotten, Christopher Sen
dc.date.accessioned2010-05-05T12:16:25Z-
dc.date.available2010-05-05T12:16:25Z-
dc.date.issued1995-11-
dc.identifier.citationEffects of IL-11 on the growth of intestinal epithelial cells in vitro. 1995, 28 (11):581-94 Cell Prolif.en
dc.identifier.issn0960-7722-
dc.identifier.pmid8555371-
dc.identifier.doi10.1111/j.1365-2184.1995.tb00046.x-
dc.identifier.urihttp://hdl.handle.net/10541/97941-
dc.description.abstractThe network of interacting factors that control proliferation in the intestinal epithelium is largely unknown. Recently, IL-11 was found to protect animals from lethal doses of cytotoxic agents. Part of this protective action was ascribed to a reduced level of damage in the intestinal epithelium. Whether this was due to a direct effect on epithelial cell cycle progression was unclear. We have addressed this question in vitro and found that IL-11 reversibly inhibited proliferation in untransformed small intestinal IEC18 cells. However, IL-11 did not inhibit transformed SW620 or HT29 colonic cell lines. IL-6 behaved in a similar manner to IL-11. Thus, these results suggest that IL-11 may be an ideal therapy adjuvant, protecting normal cells and further, these results suggest that IL-11 may be involved in the normal growth controls in the intestinal epithelium. The inhibitory response evoked by IL-11 is lost during carcinogenic transformation.en
dc.language.isoenen
dc.subjectCancerous Cell Transformationen
dc.subject.meshAnimals-
dc.subject.meshCell Division-
dc.subject.meshCell Line-
dc.subject.meshCell Transformation, Neoplastic-
dc.subject.meshColon-
dc.subject.meshDose-Response Relationship, Drug-
dc.subject.meshEpithelial Cells-
dc.subject.meshEpithelium-
dc.subject.meshInterleukin-11-
dc.subject.meshInterleukin-6-
dc.subject.meshIntestines-
dc.subject.meshRats-
dc.subject.meshTransforming Growth Factor beta-
dc.titleEffects of IL-11 on the growth of intestinal epithelial cells in vitro.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Withington, Manchester, UK.en
dc.identifier.journalCell Proliferationen
All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.