In situ comparison of 665 nm and 633 nm wavelength light penetration in the human prostate gland.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97779
Title:
In situ comparison of 665 nm and 633 nm wavelength light penetration in the human prostate gland.
Authors:
Lee, L K; Whitehurst, Colin; Pantelides, M L; Moore, James V
Abstract:
The depth of treatment in photodynamic therapy (PDT) of tumors varies with the wavelength of light activating the photosensitizer. New generation photosensitizers that are excited at longer wavelengths have the potential for increasing treatment depths. Tin ethyl etiopurpurin (SnET2), a promising second-generation photosensitizer is maximally activated at 665 nm, which may be significantly more penetrating than 633 nm light currently used with porphyrins in PDT. The penetration of 665 nm and 633 nm wavelength red light in the prostate gland was compared in 11 patients undergoing prostatic biopsies for suspected prostatic cancer. Interstitial optical fibers determined the light attenuation within the prostate gland. Of the 11 patients, 7 had dual wavelength and 4 had single wavelength studies. The mean attenuation coefficients, mueff, for 665 nm and 633 nm wavelength light were 0.32 +/- 0.05 mm-1 and 0.39 +/- 0.05 mm-1, respectively, showing a statistically significant difference (P = 0.0003). This represented a 22% increase in the mean penetration depth and at 10 mm from the delivery fiber there was 1.8 times as much 665 nm light fluence than 633 nm. The mean mueff at 665 nm for benign and malignant prostate tissue were similar (P = 0.42), however, there was significant interpatient variation (mueff ranging from 0.24 to 0.42 mm-1) reflecting biological differences of therapeutic importance. The enhanced light fluence and penetration depth with 665 nm light should allow significantly larger volumes of prostatic tissue to be treated with SnET2-mediated PDT.
Affiliation:
Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
Citation:
In situ comparison of 665 nm and 633 nm wavelength light penetration in the human prostate gland. 1995, 62 (5):882-6 Photochem. Photobiol.
Journal:
Photochemistry and Photobiology
Issue Date:
Nov-1995
URI:
http://hdl.handle.net/10541/97779
PubMed ID:
8570727
Type:
Article
Language:
en
ISSN:
0031-8655
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorLee, L Ken
dc.contributor.authorWhitehurst, Colinen
dc.contributor.authorPantelides, M Len
dc.contributor.authorMoore, James Ven
dc.date.accessioned2010-04-30T15:51:36Z-
dc.date.available2010-04-30T15:51:36Z-
dc.date.issued1995-11-
dc.identifier.citationIn situ comparison of 665 nm and 633 nm wavelength light penetration in the human prostate gland. 1995, 62 (5):882-6 Photochem. Photobiol.en
dc.identifier.issn0031-8655-
dc.identifier.pmid8570727-
dc.identifier.urihttp://hdl.handle.net/10541/97779-
dc.description.abstractThe depth of treatment in photodynamic therapy (PDT) of tumors varies with the wavelength of light activating the photosensitizer. New generation photosensitizers that are excited at longer wavelengths have the potential for increasing treatment depths. Tin ethyl etiopurpurin (SnET2), a promising second-generation photosensitizer is maximally activated at 665 nm, which may be significantly more penetrating than 633 nm light currently used with porphyrins in PDT. The penetration of 665 nm and 633 nm wavelength red light in the prostate gland was compared in 11 patients undergoing prostatic biopsies for suspected prostatic cancer. Interstitial optical fibers determined the light attenuation within the prostate gland. Of the 11 patients, 7 had dual wavelength and 4 had single wavelength studies. The mean attenuation coefficients, mueff, for 665 nm and 633 nm wavelength light were 0.32 +/- 0.05 mm-1 and 0.39 +/- 0.05 mm-1, respectively, showing a statistically significant difference (P = 0.0003). This represented a 22% increase in the mean penetration depth and at 10 mm from the delivery fiber there was 1.8 times as much 665 nm light fluence than 633 nm. The mean mueff at 665 nm for benign and malignant prostate tissue were similar (P = 0.42), however, there was significant interpatient variation (mueff ranging from 0.24 to 0.42 mm-1) reflecting biological differences of therapeutic importance. The enhanced light fluence and penetration depth with 665 nm light should allow significantly larger volumes of prostatic tissue to be treated with SnET2-mediated PDT.en
dc.language.isoenen
dc.subjectProstatic Canceren
dc.subject.meshHumans-
dc.subject.meshLaser Therapy-
dc.subject.meshMale-
dc.subject.meshPhotochemistry-
dc.subject.meshPhotochemotherapy-
dc.subject.meshPhotosensitizing Agents-
dc.subject.meshPorphyrins-
dc.subject.meshProstate-
dc.subject.meshProstatic Neoplasms-
dc.titleIn situ comparison of 665 nm and 633 nm wavelength light penetration in the human prostate gland.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalPhotochemistry and Photobiologyen

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