Frequent alterations of chromosome 1 in ductal carcinoma in situ of the breast.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97777
Title:
Frequent alterations of chromosome 1 in ductal carcinoma in situ of the breast.
Authors:
Munn, K E; Walker, R A; Varley, Jennifer
Abstract:
Ductal carcinoma in situ (DCIS) of the breast is commonly described as a premalignant lesion. Using PCR to amplify DNA from areas of tumour cells which have been microdissected from fixed material, we have studied the involvement of chromosome 1 in 19 cases of DCIS. A series of microsatellite repeat polymorphisms has been used to define regions of allelic imbalance and this has confirmed the involvement in DCIS of six of the regions previously implicated in studies of invasive breast tumours. This suggests that these regions may harbour tumour suppressor genes, the inactivation of which is important for the early stages of breast tumour development. Analysis of separate ducts from within the same tumour has revealed that the same genetic alterations are not necessarily present throughout the lesion. In addition we have found that in three cases where frank invasive carcinoma is also present, similar alterations can be detected in the in situ and invasive component.
Affiliation:
CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.
Citation:
Frequent alterations of chromosome 1 in ductal carcinoma in situ of the breast. 1995, 10 (8):1653-7 Oncogene
Journal:
Oncogene
Issue Date:
20-Apr-1995
URI:
http://hdl.handle.net/10541/97777
PubMed ID:
7731721
Type:
Article
Language:
en
ISSN:
0950-9232
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMunn, K Een
dc.contributor.authorWalker, R Aen
dc.contributor.authorVarley, Jenniferen
dc.date.accessioned2010-04-30T15:44:56Z-
dc.date.available2010-04-30T15:44:56Z-
dc.date.issued1995-04-20-
dc.identifier.citationFrequent alterations of chromosome 1 in ductal carcinoma in situ of the breast. 1995, 10 (8):1653-7 Oncogeneen
dc.identifier.issn0950-9232-
dc.identifier.pmid7731721-
dc.identifier.urihttp://hdl.handle.net/10541/97777-
dc.description.abstractDuctal carcinoma in situ (DCIS) of the breast is commonly described as a premalignant lesion. Using PCR to amplify DNA from areas of tumour cells which have been microdissected from fixed material, we have studied the involvement of chromosome 1 in 19 cases of DCIS. A series of microsatellite repeat polymorphisms has been used to define regions of allelic imbalance and this has confirmed the involvement in DCIS of six of the regions previously implicated in studies of invasive breast tumours. This suggests that these regions may harbour tumour suppressor genes, the inactivation of which is important for the early stages of breast tumour development. Analysis of separate ducts from within the same tumour has revealed that the same genetic alterations are not necessarily present throughout the lesion. In addition we have found that in three cases where frank invasive carcinoma is also present, similar alterations can be detected in the in situ and invasive component.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectTumour Suppressor Genesen
dc.subject.meshBreast Neoplasms-
dc.subject.meshCarcinoma in Situ-
dc.subject.meshCarcinoma, Ductal, Breast-
dc.subject.meshChromosome Aberrations-
dc.subject.meshChromosomes, Human, Pair 1-
dc.subject.meshFemale-
dc.subject.meshGenes, Tumor Suppressor-
dc.subject.meshHumans-
dc.titleFrequent alterations of chromosome 1 in ductal carcinoma in situ of the breast.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.en
dc.identifier.journalOncogeneen

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