The association of an HPV16 oncogene variant with HLA-B7 has implications for vaccine design in cervical cancer.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97775
Title:
The association of an HPV16 oncogene variant with HLA-B7 has implications for vaccine design in cervical cancer.
Authors:
Ellis, J R; Keating, P J; Baird, J; Hounsell, E F; Renouf, D V; Rowe, M; Hopkins, D; Duggan-Keen, Margaret F; Bartholomew, J S; Young, L S; Stern, Peter L
Abstract:
HLA-restricted cytotoxic T-lymphocyte (CTL) recognition of human papillomavirus (HPV) oncogene products may be important in the control of the HPV infections associated with the development of cervical cancer. We have identified, in HLA-B7 individuals, a consistent variation in the HPV16 E6 oncoprotein sequence, which alters an HLA-B7 peptide binding epitope in a way likely to influence immune recognition by CTLs. These results illustrate a biologically relevant mechanism for escape from immune surveillance of HPV16 in HLA-B7 individuals. Thus, both HLA type and HPV16 strain variation need to be considered in the screening of at-risk individuals and for the rational design of anti-HPV vaccines.
Affiliation:
University of Birmingham CRC Institute for Cancer Studies, University of Birmingham Medical School, UK.
Citation:
The association of an HPV16 oncogene variant with HLA-B7 has implications for vaccine design in cervical cancer. 1995, 1 (5):464-70 Nat. Med.
Journal:
Nature Medicine
Issue Date:
May-1995
URI:
http://hdl.handle.net/10541/97775
DOI:
10.1038/nm0595-464
PubMed ID:
7585096
Type:
Article
Language:
en
ISSN:
1078-8956
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorEllis, J Ren
dc.contributor.authorKeating, P Jen
dc.contributor.authorBaird, Jen
dc.contributor.authorHounsell, E Fen
dc.contributor.authorRenouf, D Ven
dc.contributor.authorRowe, Men
dc.contributor.authorHopkins, Den
dc.contributor.authorDuggan-Keen, Margaret Fen
dc.contributor.authorBartholomew, J Sen
dc.contributor.authorYoung, L Sen
dc.contributor.authorStern, Peter Len
dc.date.accessioned2010-04-30T15:41:19Z-
dc.date.available2010-04-30T15:41:19Z-
dc.date.issued1995-05-
dc.identifier.citationThe association of an HPV16 oncogene variant with HLA-B7 has implications for vaccine design in cervical cancer. 1995, 1 (5):464-70 Nat. Med.en
dc.identifier.issn1078-8956-
dc.identifier.pmid7585096-
dc.identifier.doi10.1038/nm0595-464-
dc.identifier.urihttp://hdl.handle.net/10541/97775-
dc.description.abstractHLA-restricted cytotoxic T-lymphocyte (CTL) recognition of human papillomavirus (HPV) oncogene products may be important in the control of the HPV infections associated with the development of cervical cancer. We have identified, in HLA-B7 individuals, a consistent variation in the HPV16 E6 oncoprotein sequence, which alters an HLA-B7 peptide binding epitope in a way likely to influence immune recognition by CTLs. These results illustrate a biologically relevant mechanism for escape from immune surveillance of HPV16 in HLA-B7 individuals. Thus, both HLA type and HPV16 strain variation need to be considered in the screening of at-risk individuals and for the rational design of anti-HPV vaccines.en
dc.language.isoenen
dc.subjectUterine Cervical Canceren
dc.subject.meshAmino Acid Sequence-
dc.subject.meshEpitopes-
dc.subject.meshFemale-
dc.subject.meshHLA-B7 Antigen-
dc.subject.meshHumans-
dc.subject.meshMolecular Sequence Data-
dc.subject.meshMutation-
dc.subject.meshOncogene Proteins, Viral-
dc.subject.meshPapillomaviridae-
dc.subject.meshProtein Binding-
dc.subject.meshRepressor Proteins-
dc.subject.meshSequence Analysis, DNA-
dc.subject.meshT-Lymphocytes, Cytotoxic-
dc.subject.meshTranscription Factors-
dc.subject.meshUterine Cervical Neoplasms-
dc.subject.meshViral Vaccines-
dc.titleThe association of an HPV16 oncogene variant with HLA-B7 has implications for vaccine design in cervical cancer.en
dc.typeArticleen
dc.contributor.departmentUniversity of Birmingham CRC Institute for Cancer Studies, University of Birmingham Medical School, UK.en
dc.identifier.journalNature Medicineen

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