Low-level direct electrical current therapy for hepatic metastases. I. Preclinical studies on normal liver.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97485
Title:
Low-level direct electrical current therapy for hepatic metastases. I. Preclinical studies on normal liver.
Authors:
Griffin, D T; Dodd, Nicholas J F; Zhao, S; Pullan, B R; Moore, James V
Abstract:
Low-level direct electrical current has shown promise as a potential therapeutic modality (direct current therapy; DCT) in the treatment of malignant disease, including metastases, but to date much experimental work has been empirical and has added little to our knowledge of the mechanisms involved. As a prerequisite to a clinical trial for metastases in the liver, we have employed an in vivo liver model to examine the quantitative and qualitative relationships between electrode polarity, charge and tissue necrosis. Two distinct regions of necrosis were induced, distinguishable histologically and by magnetic resonance imaging: (i) a cylindrical region of primary necrosis centred on the electrode, its volume directly proportional to the charge passed, but greater at the anode than cathode; and (ii) a wedge-shaped infarct, apex at the electrode and base extending to the liver edge. The extent of this infarct was again greater at the anode than the cathode, but showed a sigmoidal relationship with charge. Results indicate pH changes at the electrodes as likely mediators of tissue injury, but show also that significant distant ischaemic injury can occur as a consequence of primary damage. These findings should be considered when selecting tumours for possible direct current therapy and when determining the sites of electrode placement.
Affiliation:
Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK.
Citation:
Low-level direct electrical current therapy for hepatic metastases. I. Preclinical studies on normal liver. 1995, 72 (1):31-4 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
Jul-1995
URI:
http://hdl.handle.net/10541/97485
PubMed ID:
7599063
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorGriffin, D Ten
dc.contributor.authorDodd, Nicholas J Fen
dc.contributor.authorZhao, Sen
dc.contributor.authorPullan, B Ren
dc.contributor.authorMoore, James Ven
dc.date.accessioned2010-04-27T13:47:40Z-
dc.date.available2010-04-27T13:47:40Z-
dc.date.issued1995-07-
dc.identifier.citationLow-level direct electrical current therapy for hepatic metastases. I. Preclinical studies on normal liver. 1995, 72 (1):31-4 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid7599063-
dc.identifier.urihttp://hdl.handle.net/10541/97485-
dc.description.abstractLow-level direct electrical current has shown promise as a potential therapeutic modality (direct current therapy; DCT) in the treatment of malignant disease, including metastases, but to date much experimental work has been empirical and has added little to our knowledge of the mechanisms involved. As a prerequisite to a clinical trial for metastases in the liver, we have employed an in vivo liver model to examine the quantitative and qualitative relationships between electrode polarity, charge and tissue necrosis. Two distinct regions of necrosis were induced, distinguishable histologically and by magnetic resonance imaging: (i) a cylindrical region of primary necrosis centred on the electrode, its volume directly proportional to the charge passed, but greater at the anode than cathode; and (ii) a wedge-shaped infarct, apex at the electrode and base extending to the liver edge. The extent of this infarct was again greater at the anode than the cathode, but showed a sigmoidal relationship with charge. Results indicate pH changes at the electrodes as likely mediators of tissue injury, but show also that significant distant ischaemic injury can occur as a consequence of primary damage. These findings should be considered when selecting tumours for possible direct current therapy and when determining the sites of electrode placement.en
dc.language.isoenen
dc.subjectLiver Canceren
dc.subject.meshAnimals-
dc.subject.meshElectric Stimulation Therapy-
dc.subject.meshLiver-
dc.subject.meshLiver Neoplasms-
dc.subject.meshMale-
dc.subject.meshNecrosis-
dc.subject.meshRats-
dc.titleLow-level direct electrical current therapy for hepatic metastases. I. Preclinical studies on normal liver.en
dc.typeArticleen
dc.contributor.departmentPaterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren

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