The Hox-2.4 gene is not involved in the generation of IL-3 dependent multipotent FDCP-mix cell lines.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97477
Title:
The Hox-2.4 gene is not involved in the generation of IL-3 dependent multipotent FDCP-mix cell lines.
Authors:
Just, Ursula; Kan, On; Fennelly, Jan; Dexter, T Michael; Spooncer, Elaine
Abstract:
The establishment of IL-3-dependent multipotent progenitor cell lines from Hox-2.4-expressing bone marrow cells suggests that homeobox genes may contribute to immortalization of early myeloid cells. A survey of 20 independently derived multipotent IL-3-dependent cell lines established from either src-virus-infected long-term bone marrow cultures (FDCP-mix) or Multi-CSF-virus (M3MuV)-infected bone marrow revealed that Hox-2.4 was not expressed in any of these cell lines. In addition DNA rearrangements were not observed. We conclude that activation of Hox-2.4 is not an obligatory event in the immortalization of early myeloid cells.
Affiliation:
Department of Experimental Haematology, Paterson Institute for Cancer Research, Manchester, UK.
Citation:
The Hox-2.4 gene is not involved in the generation of IL-3 dependent multipotent FDCP-mix cell lines. 1995, 12 (3):173-7 Growth Factors
Journal:
Growth Factors
Issue Date:
1995
URI:
http://hdl.handle.net/10541/97477
DOI:
10.3109/08977199509036877
PubMed ID:
8619923
Type:
Article
Language:
en
ISSN:
0897-7194
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorJust, Ursulaen
dc.contributor.authorKan, Onen
dc.contributor.authorFennelly, Janen
dc.contributor.authorDexter, T Michaelen
dc.contributor.authorSpooncer, Elaineen
dc.date.accessioned2010-04-27T12:48:58Z-
dc.date.available2010-04-27T12:48:58Z-
dc.date.issued1995-
dc.identifier.citationThe Hox-2.4 gene is not involved in the generation of IL-3 dependent multipotent FDCP-mix cell lines. 1995, 12 (3):173-7 Growth Factorsen
dc.identifier.issn0897-7194-
dc.identifier.pmid8619923-
dc.identifier.doi10.3109/08977199509036877-
dc.identifier.urihttp://hdl.handle.net/10541/97477-
dc.description.abstractThe establishment of IL-3-dependent multipotent progenitor cell lines from Hox-2.4-expressing bone marrow cells suggests that homeobox genes may contribute to immortalization of early myeloid cells. A survey of 20 independently derived multipotent IL-3-dependent cell lines established from either src-virus-infected long-term bone marrow cultures (FDCP-mix) or Multi-CSF-virus (M3MuV)-infected bone marrow revealed that Hox-2.4 was not expressed in any of these cell lines. In addition DNA rearrangements were not observed. We conclude that activation of Hox-2.4 is not an obligatory event in the immortalization of early myeloid cells.en
dc.language.isoenen
dc.subjectCancer Proteinsen
dc.subjectHaematopoietic Stem Cellsen
dc.subjectMurine Virus Leukaemiaen
dc.subject.meshAnimals-
dc.subject.meshBone Marrow Cells-
dc.subject.meshCell Line-
dc.subject.meshGene Expression-
dc.subject.meshGene Rearrangement-
dc.subject.meshGenes, Homeobox-
dc.subject.meshHematopoietic Stem Cells-
dc.subject.meshHomeodomain Proteins-
dc.subject.meshHumans-
dc.subject.meshInterleukin-3-
dc.subject.meshLeukemia Virus, Murine-
dc.subject.meshMice-
dc.subject.meshNeoplasm Proteins-
dc.subject.meshTranscription Factors-
dc.titleThe Hox-2.4 gene is not involved in the generation of IL-3 dependent multipotent FDCP-mix cell lines.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Haematology, Paterson Institute for Cancer Research, Manchester, UK.en
dc.identifier.journalGrowth Factorsen
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