The interaction with tubulin of a series of stilbenes based on combretastatin A-4.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97461
Title:
The interaction with tubulin of a series of stilbenes based on combretastatin A-4.
Authors:
Woods, J A; Hadfield, John A; Pettit, G R; Fox, Brian W; McGown, Alan T
Abstract:
A series of stilbenes, based on combretastatin A-4, were synthesised. A structure-activity study was carried out to characterise the interaction of these agents with tubulin. The substitution of small alkyl substituents for the 4'-methoxy group of combretastatin A-4 and the loss of the 3'-hydroxyl group does not have a major effect on the interaction with tubulin. trans-Stilbenes were shown to bind tubulin, but do not inhibit microtubule assembly. This work, together with previous studies, has been used to propose an idealised structure for a tubulin-binding agent of this type.
Affiliation:
CRC Department of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.
Citation:
The interaction with tubulin of a series of stilbenes based on combretastatin A-4. 1995, 71 (4):705-11 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
Apr-1995
URI:
http://hdl.handle.net/10541/97461
PubMed ID:
7710932
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorWoods, J Aen
dc.contributor.authorHadfield, John Aen
dc.contributor.authorPettit, G Ren
dc.contributor.authorFox, Brian Wen
dc.contributor.authorMcGown, Alan Ten
dc.date.accessioned2010-04-27T13:59:27Z-
dc.date.available2010-04-27T13:59:27Z-
dc.date.issued1995-04-
dc.identifier.citationThe interaction with tubulin of a series of stilbenes based on combretastatin A-4. 1995, 71 (4):705-11 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid7710932-
dc.identifier.urihttp://hdl.handle.net/10541/97461-
dc.description.abstractA series of stilbenes, based on combretastatin A-4, were synthesised. A structure-activity study was carried out to characterise the interaction of these agents with tubulin. The substitution of small alkyl substituents for the 4'-methoxy group of combretastatin A-4 and the loss of the 3'-hydroxyl group does not have a major effect on the interaction with tubulin. trans-Stilbenes were shown to bind tubulin, but do not inhibit microtubule assembly. This work, together with previous studies, has been used to propose an idealised structure for a tubulin-binding agent of this type.en
dc.language.isoenen
dc.subjectLeukaemia P388en
dc.subjectCultured Tumour Cellsen
dc.subject.meshAnimals-
dc.subject.meshAntineoplastic Agents, Phytogenic-
dc.subject.meshBinding, Competitive-
dc.subject.meshCell Cycle-
dc.subject.meshLeukemia P388-
dc.subject.meshMice-
dc.subject.meshMicrotubules-
dc.subject.meshMitotic Index-
dc.subject.meshMolecular Structure-
dc.subject.meshStilbenes-
dc.subject.meshStructure-Activity Relationship-
dc.subject.meshThermodynamics-
dc.subject.meshTubulin-
dc.subject.meshTumor Cells, Cultured-
dc.titleThe interaction with tubulin of a series of stilbenes based on combretastatin A-4.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.