2.50
Hdl Handle:
http://hdl.handle.net/10541/97460
Title:
Allelic imbalance of chromosome 6q in ovarian tumours.
Authors:
Orphanos, Vassilis; McGown, Gail; Hey, Yvonne; Thorncroft, Mary R; Santibanez-Koref, Mauro F; Russell, S E; Hickey, I; Atkinson, R J; Boyle, John M
Abstract:
Previous work has implicated putative tumour-suppressor (ts) genes at 6q27 and a broad region at 6p12-q23. Here we report the results of a coded, randomised study of allelic imbalance at 12 loci on 6q on 40 pairs of coded tumour-blood pairs from patients with ovarian tumours. Our results provide clear evidence for the involvement of different regions of 6q in tumours of different histological subtypes. The involvement in serous tumours of a ts gene at the distal site is confirmed. However, proximal 6q presents a complex picture, with possibly three further ts genes: one at 6q21-23.3 involved at high frequency in benign and endometrioid tumours, another at 6q14-q15, also involved in endometrioid tumours, and a third suggested by a smallest region of deletion at 6q16.3-q21, between D6S275 and D6S300, that appears to be involved in early stage tumours. These observations point the way to a statistical study of the involvement of 6q in tumours of different histological type and staging performed on larger cohorts of samples.
Affiliation:
Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie CRC Research Centre, Manchester, UK.
Citation:
Allelic imbalance of chromosome 6q in ovarian tumours. 1995, 71 (4):666-9 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
Apr-1995
URI:
http://hdl.handle.net/10541/97460
PubMed ID:
7710926
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorOrphanos, Vassilisen
dc.contributor.authorMcGown, Gailen
dc.contributor.authorHey, Yvonneen
dc.contributor.authorThorncroft, Mary Ren
dc.contributor.authorSantibanez-Koref, Mauro Fen
dc.contributor.authorRussell, S Een
dc.contributor.authorHickey, Ien
dc.contributor.authorAtkinson, R Jen
dc.contributor.authorBoyle, John Men
dc.date.accessioned2010-04-27T13:52:19Z-
dc.date.available2010-04-27T13:52:19Z-
dc.date.issued1995-04-
dc.identifier.citationAllelic imbalance of chromosome 6q in ovarian tumours. 1995, 71 (4):666-9 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid7710926-
dc.identifier.urihttp://hdl.handle.net/10541/97460-
dc.description.abstractPrevious work has implicated putative tumour-suppressor (ts) genes at 6q27 and a broad region at 6p12-q23. Here we report the results of a coded, randomised study of allelic imbalance at 12 loci on 6q on 40 pairs of coded tumour-blood pairs from patients with ovarian tumours. Our results provide clear evidence for the involvement of different regions of 6q in tumours of different histological subtypes. The involvement in serous tumours of a ts gene at the distal site is confirmed. However, proximal 6q presents a complex picture, with possibly three further ts genes: one at 6q21-23.3 involved at high frequency in benign and endometrioid tumours, another at 6q14-q15, also involved in endometrioid tumours, and a third suggested by a smallest region of deletion at 6q16.3-q21, between D6S275 and D6S300, that appears to be involved in early stage tumours. These observations point the way to a statistical study of the involvement of 6q in tumours of different histological type and staging performed on larger cohorts of samples.en
dc.language.isoenen
dc.subjectCancer DNAen
dc.subjectCancer Stagingen
dc.subjectEndometrial Canceren
dc.subjectOvarian Canceren
dc.subject.meshAdenocarcinoma, Mucinous-
dc.subject.meshAlleles-
dc.subject.meshCarcinoma-
dc.subject.meshChromosome Deletion-
dc.subject.meshChromosome Mapping-
dc.subject.meshChromosomes, Human, Pair 6-
dc.subject.meshCystadenocarcinoma-
dc.subject.meshDNA, Neoplasm-
dc.subject.meshDNA, Satellite-
dc.subject.meshEndometrial Neoplasms-
dc.subject.meshFemale-
dc.subject.meshGenetic Markers-
dc.subject.meshHumans-
dc.subject.meshNeoplasm Staging-
dc.subject.meshOvarian Neoplasms-
dc.titleAllelic imbalance of chromosome 6q in ovarian tumours.en
dc.typeArticleen
dc.contributor.departmentDepartment of Cancer Genetics, Paterson Institute for Cancer Research, Christie CRC Research Centre, Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.