Detailed mapping and loss of heterozygosity analysis suggests a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17p13.3.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97437
Title:
Detailed mapping and loss of heterozygosity analysis suggests a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17p13.3.
Authors:
Stack, Maria; Jones, David; White, Gavin R M; Liscia, D S; Venesio, T; Casey, G; Crichton, D; Varley, Jennifer; Mitchell, Erika L D; Heighway, Jim; Santibanez-Koref, Mauro F
Abstract:
The chromosome region 17p13.3 is thought to encode a tumour suppressor gene involved in sporadic breast cancer and other malignancies. Physical ordering of markers has been carried out by a series of multicolour fluorescent in situ hybridisation (FISH) experiments, using isolated yeast artificial chromosomes (YACs) and cosmids. Eight polymorphic markers ordered within this new physical map and one external marker were used to investigate the pattern of loss of heterozygosity in a panel of 40 sporadic breast tumour patients. The data revealed a region of high loss (60%) within distal 17p13.3, defined by markers D17S926, D17S695 and D17S849 which mapped close together. A contig of YACs was constructed physically linking these three markers.
Affiliation:
CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.
Citation:
Detailed mapping and loss of heterozygosity analysis suggests a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17p13.3. 1995, 4 (11):2047-55 Hum. Mol. Genet.
Journal:
Human Molecular Genetics
Issue Date:
Nov-1995
URI:
http://hdl.handle.net/10541/97437
DOI:
10.1093/hmg/4.11.2047
PubMed ID:
8589680
Type:
Article
Language:
en
ISSN:
0964-6906
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorStack, Mariaen
dc.contributor.authorJones, Daviden
dc.contributor.authorWhite, Gavin R Men
dc.contributor.authorLiscia, D Sen
dc.contributor.authorVenesio, Ten
dc.contributor.authorCasey, Gen
dc.contributor.authorCrichton, Den
dc.contributor.authorVarley, Jenniferen
dc.contributor.authorMitchell, Erika L Den
dc.contributor.authorHeighway, Jimen
dc.contributor.authorSantibanez-Koref, Mauro Fen
dc.date.accessioned2010-04-27T11:07:16Z-
dc.date.available2010-04-27T11:07:16Z-
dc.date.issued1995-11-
dc.identifier.citationDetailed mapping and loss of heterozygosity analysis suggests a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17p13.3. 1995, 4 (11):2047-55 Hum. Mol. Genet.en
dc.identifier.issn0964-6906-
dc.identifier.pmid8589680-
dc.identifier.doi10.1093/hmg/4.11.2047-
dc.identifier.urihttp://hdl.handle.net/10541/97437-
dc.description.abstractThe chromosome region 17p13.3 is thought to encode a tumour suppressor gene involved in sporadic breast cancer and other malignancies. Physical ordering of markers has been carried out by a series of multicolour fluorescent in situ hybridisation (FISH) experiments, using isolated yeast artificial chromosomes (YACs) and cosmids. Eight polymorphic markers ordered within this new physical map and one external marker were used to investigate the pattern of loss of heterozygosity in a panel of 40 sporadic breast tumour patients. The data revealed a region of high loss (60%) within distal 17p13.3, defined by markers D17S926, D17S695 and D17S849 which mapped close together. A contig of YACs was constructed physically linking these three markers.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectTumour Suppressor Genesen
dc.subject.meshBase Sequence-
dc.subject.meshBreast Neoplasms-
dc.subject.meshChromosome Banding-
dc.subject.meshChromosome Deletion-
dc.subject.meshChromosome Mapping-
dc.subject.meshChromosomes, Artificial, Yeast-
dc.subject.meshChromosomes, Human, Pair 17-
dc.subject.meshFemale-
dc.subject.meshGenes, Tumor Suppressor-
dc.subject.meshHeterozygote-
dc.subject.meshHumans-
dc.subject.meshIn Situ Hybridization, Fluorescence-
dc.subject.meshMolecular Sequence Data-
dc.titleDetailed mapping and loss of heterozygosity analysis suggests a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17p13.3.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.en
dc.identifier.journalHuman Molecular Geneticsen

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