Plasma-membrane-bound macromolecules are dynamically aggregated to form non-random codistribution patterns of selected functional elements. Do pattern recognition processes govern antigen presentation and intercellular interactions?

2.50
Hdl Handle:
http://hdl.handle.net/10541/97420
Title:
Plasma-membrane-bound macromolecules are dynamically aggregated to form non-random codistribution patterns of selected functional elements. Do pattern recognition processes govern antigen presentation and intercellular interactions?
Authors:
Vereb, G; Mátyus, L; Bene, L; Panyi, G; Bacsó, Z; Balázs, M; Matkó, J; Szöllösi, J; Gáspár, R; Damjanovich, S; Dale, Robert E
Abstract:
Molecular recognition processes between cell surface elements are discussed with special reference to cell surface pattern formation of membrane-bound integral proteins. The existence, as detected by flow cytometric resonance energy transfer (Appendix), and significance of cell surface patterns involving the interleukin-2 receptor, the T-cell receptor-CD3 system, the intercellular adhesion molecule ICAM-1, and the major histocompatibility complex class I and class II molecules in the plasma membrane of lymphocytes are described. The modulation of antigen presentation by transmembrane potential changes is discussed, and a general role of transmembrane potential changes, and therefore of ion channel activities, adduced as one of the major regulatory mechanisms of cell-cell communication. A general role in the mediation and regulation of intercellular interactions is suggested for cell-surface macromolecular patterns. The dynamic pattern of protein and lipid molecules in the plasma membrane is generated by the genetic code, but has a remarkable flexibility and may be one of the major instruments of accommodation and recognition processes at the cellular level.
Affiliation:
Department of Biophysics, University Medical School of Debrecen, Hungary.
Citation:
Plasma-membrane-bound macromolecules are dynamically aggregated to form non-random codistribution patterns of selected functional elements. Do pattern recognition processes govern antigen presentation and intercellular interactions?, 8 (4):237-46 J. Mol. Recognit.
Journal:
Journal of Molecular Recognition
Issue Date:
1995
URI:
http://hdl.handle.net/10541/97420
DOI:
10.1002/jmr.300080402
PubMed ID:
8588941
Type:
Article
Language:
en
ISSN:
0952-3499
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorVereb, Gen
dc.contributor.authorMátyus, Len
dc.contributor.authorBene, Len
dc.contributor.authorPanyi, Gen
dc.contributor.authorBacsó, Zen
dc.contributor.authorBalázs, Men
dc.contributor.authorMatkó, Jen
dc.contributor.authorSzöllösi, Jen
dc.contributor.authorGáspár, Ren
dc.contributor.authorDamjanovich, Sen
dc.contributor.authorDale, Robert Een
dc.date.accessioned2010-04-26T15:02:09Z-
dc.date.available2010-04-26T15:02:09Z-
dc.date.issued1995-
dc.identifier.citationPlasma-membrane-bound macromolecules are dynamically aggregated to form non-random codistribution patterns of selected functional elements. Do pattern recognition processes govern antigen presentation and intercellular interactions?, 8 (4):237-46 J. Mol. Recognit.en
dc.identifier.issn0952-3499-
dc.identifier.pmid8588941-
dc.identifier.doi10.1002/jmr.300080402-
dc.identifier.urihttp://hdl.handle.net/10541/97420-
dc.description.abstractMolecular recognition processes between cell surface elements are discussed with special reference to cell surface pattern formation of membrane-bound integral proteins. The existence, as detected by flow cytometric resonance energy transfer (Appendix), and significance of cell surface patterns involving the interleukin-2 receptor, the T-cell receptor-CD3 system, the intercellular adhesion molecule ICAM-1, and the major histocompatibility complex class I and class II molecules in the plasma membrane of lymphocytes are described. The modulation of antigen presentation by transmembrane potential changes is discussed, and a general role of transmembrane potential changes, and therefore of ion channel activities, adduced as one of the major regulatory mechanisms of cell-cell communication. A general role in the mediation and regulation of intercellular interactions is suggested for cell-surface macromolecular patterns. The dynamic pattern of protein and lipid molecules in the plasma membrane is generated by the genetic code, but has a remarkable flexibility and may be one of the major instruments of accommodation and recognition processes at the cellular level.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshAntigens, CD3-
dc.subject.meshAntigens, Surface-
dc.subject.meshCell Communication-
dc.subject.meshEnergy Transfer-
dc.subject.meshFlow Cytometry-
dc.subject.meshHumans-
dc.subject.meshIntercellular Adhesion Molecule-1-
dc.subject.meshMajor Histocompatibility Complex-
dc.subject.meshMembrane Potentials-
dc.subject.meshMembrane Proteins-
dc.subject.meshReceptors, Antigen, T-Cell-
dc.subject.meshReceptors, Cell Surface-
dc.subject.meshReceptors, Interleukin-2-
dc.titlePlasma-membrane-bound macromolecules are dynamically aggregated to form non-random codistribution patterns of selected functional elements. Do pattern recognition processes govern antigen presentation and intercellular interactions?en
dc.typeArticleen
dc.contributor.departmentDepartment of Biophysics, University Medical School of Debrecen, Hungary.en
dc.identifier.journalJournal of Molecular Recognitionen

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