Common region of deletion on the long arm of chromosome 6 in non-Hodgkin's lymphoma and acute lymphoblastic leukaemia.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97361
Title:
Common region of deletion on the long arm of chromosome 6 in non-Hodgkin's lymphoma and acute lymphoblastic leukaemia.
Authors:
Menasce, Lia P; Orphanos, Vassilis; Santibanez-Koref, Mauro F; Boyle, John M; Harrison, Christine J
Abstract:
We have used fluorescence in situ hybridisation (FISH) with a series of yeast artificial chromosome (YAC) clones that map to the long arm of chromosome 6 (6q) to define the region(s) of deletion in seven cases of non-Hodgkin's lymphoma (NHL), in which a deletion of 6q had been detected by conventional cytogenetics. The FISH analysis detected two regions of deletion: (i) A proximal region flanked by M6P1 (6q14-15) and FYN (6q21), containing D6S246, which was missing in all seven cases. This locus was also found to be deleted in all six cases of acute lymphoblastic leukaemia (ALL) studied previously. (ii) A second region of 6q, which was distal to 6q23.1 (D6S238) and included ESR (6q25.1) and D6S281 (6q27), which was shown to be present in all our cases of ALL, was found to be deleted in 4 of the 7 cases of NHL. Our results support the suggestion that tumour suppressor genes, involved in the pathogenesis of lymphoid malignancies, may be present within these regions.
Affiliation:
Department of Histopathology, Christie Hospital, Manchester, UK.
Citation:
Common region of deletion on the long arm of chromosome 6 in non-Hodgkin's lymphoma and acute lymphoblastic leukaemia. 1994, 10 (4):286-8 Genes Chromosomes Cancer
Journal:
Genes, Chromosomes & Cancer
Issue Date:
Aug-1994
URI:
http://hdl.handle.net/10541/97361
DOI:
10.1002/gcc.2870100411
PubMed ID:
7522544
Type:
Article
Language:
en
ISSN:
1045-2257
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMenasce, Lia Pen
dc.contributor.authorOrphanos, Vassilisen
dc.contributor.authorSantibanez-Koref, Mauro Fen
dc.contributor.authorBoyle, John Men
dc.contributor.authorHarrison, Christine Jen
dc.date.accessioned2010-04-26T09:24:15Z-
dc.date.available2010-04-26T09:24:15Z-
dc.date.issued1994-08-
dc.identifier.citationCommon region of deletion on the long arm of chromosome 6 in non-Hodgkin's lymphoma and acute lymphoblastic leukaemia. 1994, 10 (4):286-8 Genes Chromosomes Canceren
dc.identifier.issn1045-2257-
dc.identifier.pmid7522544-
dc.identifier.doi10.1002/gcc.2870100411-
dc.identifier.urihttp://hdl.handle.net/10541/97361-
dc.description.abstractWe have used fluorescence in situ hybridisation (FISH) with a series of yeast artificial chromosome (YAC) clones that map to the long arm of chromosome 6 (6q) to define the region(s) of deletion in seven cases of non-Hodgkin's lymphoma (NHL), in which a deletion of 6q had been detected by conventional cytogenetics. The FISH analysis detected two regions of deletion: (i) A proximal region flanked by M6P1 (6q14-15) and FYN (6q21), containing D6S246, which was missing in all seven cases. This locus was also found to be deleted in all six cases of acute lymphoblastic leukaemia (ALL) studied previously. (ii) A second region of 6q, which was distal to 6q23.1 (D6S238) and included ESR (6q25.1) and D6S281 (6q27), which was shown to be present in all our cases of ALL, was found to be deleted in 4 of the 7 cases of NHL. Our results support the suggestion that tumour suppressor genes, involved in the pathogenesis of lymphoid malignancies, may be present within these regions.en
dc.language.isoenen
dc.subjectPrecursor Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshChromosome Deletion-
dc.subject.meshChromosomes, Human, Pair 6-
dc.subject.meshFemale-
dc.subject.meshGenetic Markers-
dc.subject.meshHumans-
dc.subject.meshIn Situ Hybridization, Fluorescence-
dc.subject.meshLymphoma, Non-Hodgkin-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma-
dc.titleCommon region of deletion on the long arm of chromosome 6 in non-Hodgkin's lymphoma and acute lymphoblastic leukaemia.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital, Manchester, UK.en
dc.identifier.journalGenes, Chromosomes & Canceren

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