Deletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97360
Title:
Deletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia.
Authors:
Menasce, Lia P; Orphanos, Vassilis; Santibanez-Koref, Mauro F; Boyle, John M; Harrison, Christine J
Abstract:
We have characterised a region of deletion on the long arm of chromosome 6 (6q) in six cases of acute lymphoblastic leukaemia, by fluorescence in situ hybridisation, using a series of YAC clones which map to 6q. Conventional cytogenetic analysis of four of these cases had been interpreted as showing terminal deletions of 6q. We demonstrated by FISH that in all cases the deletions were interstitial. D6S246 (6q16.3) was the only marker which was missing in all six cases, indicating a common region of deletion between the markers M6P1 at 6q14-15 and FYN at 6q21. Our results suggest the presence of a tumour suppressor gene within this interval.
Affiliation:
Department of Histopathology, Christie Hospital, Manchester, United Kingdom.
Citation:
Deletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia. 1994, 10 (1):26-9 Genes Chromosomes Cancer
Journal:
Genes, Chromosomes & Cancer
Issue Date:
May-1994
URI:
http://hdl.handle.net/10541/97360
DOI:
10.1002/gcc.2870100105
PubMed ID:
7519870
Type:
Article
Language:
en
ISSN:
1045-2257
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorMenasce, Lia Pen
dc.contributor.authorOrphanos, Vassilisen
dc.contributor.authorSantibanez-Koref, Mauro Fen
dc.contributor.authorBoyle, John Men
dc.contributor.authorHarrison, Christine Jen
dc.date.accessioned2010-04-26T09:15:03Z-
dc.date.available2010-04-26T09:15:03Z-
dc.date.issued1994-05-
dc.identifier.citationDeletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia. 1994, 10 (1):26-9 Genes Chromosomes Canceren
dc.identifier.issn1045-2257-
dc.identifier.pmid7519870-
dc.identifier.doi10.1002/gcc.2870100105-
dc.identifier.urihttp://hdl.handle.net/10541/97360-
dc.description.abstractWe have characterised a region of deletion on the long arm of chromosome 6 (6q) in six cases of acute lymphoblastic leukaemia, by fluorescence in situ hybridisation, using a series of YAC clones which map to 6q. Conventional cytogenetic analysis of four of these cases had been interpreted as showing terminal deletions of 6q. We demonstrated by FISH that in all cases the deletions were interstitial. D6S246 (6q16.3) was the only marker which was missing in all six cases, indicating a common region of deletion between the markers M6P1 at 6q14-15 and FYN at 6q21. Our results suggest the presence of a tumour suppressor gene within this interval.en
dc.language.isoenen
dc.subjectPrecursor Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshChromosome Deletion-
dc.subject.meshChromosomes, Artificial, Yeast-
dc.subject.meshChromosomes, Human, Pair 6-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIn Situ Hybridization, Fluorescence-
dc.subject.meshMale-
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma-
dc.titleDeletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital, Manchester, United Kingdom.en
dc.identifier.journalGenes, Chromosomes & Canceren

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