Staging, volume estimation and assessment of nodal status in carcinoma of the cervix: comparison of magnetic resonance imaging with surgical findings.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97276
Title:
Staging, volume estimation and assessment of nodal status in carcinoma of the cervix: comparison of magnetic resonance imaging with surgical findings.
Authors:
Hawnaur, J M; Johnson, Richard J; Buckley, C H; Tindall, V R; Isherwood, I
Abstract:
Pre-operative magnetic resonance imaging (MRI) was carried out in 50 women scheduled for operative treatment of invasive carcinoma of the cervix. The extent of the primary tumour (stage), its dimensions and the presence of lymph node enlargement were assessed and compared with findings at surgery and/or histopathological examination of the resected uterus. In 45 patients undergoing radical hysterectomy, accuracy of MRI staging of the primary tumour was 84.4%. In the group as a whole, including four patients with inoperable disease, staging accuracy was 84%. Most errors were due to difficulty in identifying early vaginal or parametrial invasion by tumour. There was close correlation between the volume of tumour measured from pre-operative MRI scans and measurements made on the hysterectomy specimen (r = 0.95). MRI had a sensitivity of 75% and a specificity of 88% in predicting metastatic lymphadenopathy, based solely on the criterion of enlargement of any pelvic or para-aortic nodes to 1.5 cm or greater. However, retrospective analysis of the presence or absence of metastases by site in 49 patients undergoing lymphadenectomy or lymph node sampling at laparotomy showed that true sensitivity to be 57.1% and the specificity 96.8%. Differentiation between malignant and reactive lymphadenopathy was not reliably achieved on MRI, and in several patients, metastases were present in normal-sized lymph nodes.
Affiliation:
Department of Diagnostic Radiology, University of Manchester.
Citation:
Staging, volume estimation and assessment of nodal status in carcinoma of the cervix: comparison of magnetic resonance imaging with surgical findings. 1994, 49 (7):443-52 Clin Radiol
Journal:
Clinical Radiology
Issue Date:
Jul-1994
URI:
http://hdl.handle.net/10541/97276
DOI:
10.1016/S0009-9260(05)81738-6
PubMed ID:
8088035
Type:
Article
Language:
en
ISSN:
0009-9260
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHawnaur, J Men
dc.contributor.authorJohnson, Richard Jen
dc.contributor.authorBuckley, C Hen
dc.contributor.authorTindall, V Ren
dc.contributor.authorIsherwood, Ien
dc.date.accessioned2010-04-23T10:20:17Z-
dc.date.available2010-04-23T10:20:17Z-
dc.date.issued1994-07-
dc.identifier.citationStaging, volume estimation and assessment of nodal status in carcinoma of the cervix: comparison of magnetic resonance imaging with surgical findings. 1994, 49 (7):443-52 Clin Radiolen
dc.identifier.issn0009-9260-
dc.identifier.pmid8088035-
dc.identifier.doi10.1016/S0009-9260(05)81738-6-
dc.identifier.urihttp://hdl.handle.net/10541/97276-
dc.description.abstractPre-operative magnetic resonance imaging (MRI) was carried out in 50 women scheduled for operative treatment of invasive carcinoma of the cervix. The extent of the primary tumour (stage), its dimensions and the presence of lymph node enlargement were assessed and compared with findings at surgery and/or histopathological examination of the resected uterus. In 45 patients undergoing radical hysterectomy, accuracy of MRI staging of the primary tumour was 84.4%. In the group as a whole, including four patients with inoperable disease, staging accuracy was 84%. Most errors were due to difficulty in identifying early vaginal or parametrial invasion by tumour. There was close correlation between the volume of tumour measured from pre-operative MRI scans and measurements made on the hysterectomy specimen (r = 0.95). MRI had a sensitivity of 75% and a specificity of 88% in predicting metastatic lymphadenopathy, based solely on the criterion of enlargement of any pelvic or para-aortic nodes to 1.5 cm or greater. However, retrospective analysis of the presence or absence of metastases by site in 49 patients undergoing lymphadenectomy or lymph node sampling at laparotomy showed that true sensitivity to be 57.1% and the specificity 96.8%. Differentiation between malignant and reactive lymphadenopathy was not reliably achieved on MRI, and in several patients, metastases were present in normal-sized lymph nodes.en
dc.language.isoenen
dc.subjectCancer Invasivenessen
dc.subjectCancer Stagingen
dc.subjectUterine Cervical Canceren
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshCervix Uteri-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshHyperplasia-
dc.subject.meshLymph Nodes-
dc.subject.meshMagnetic Resonance Imaging-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasm Invasiveness-
dc.subject.meshNeoplasm Staging-
dc.subject.meshPreoperative Care-
dc.subject.meshSensitivity and Specificity-
dc.subject.meshUterine Cervical Neoplasms-
dc.titleStaging, volume estimation and assessment of nodal status in carcinoma of the cervix: comparison of magnetic resonance imaging with surgical findings.en
dc.typeArticleen
dc.contributor.departmentDepartment of Diagnostic Radiology, University of Manchester.en
dc.identifier.journalClinical Radiologyen

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