Stimulation of UV-induced DNA excision repair by chemotherapeutic drugs in cancer patients.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97239
Title:
Stimulation of UV-induced DNA excision repair by chemotherapeutic drugs in cancer patients.
Authors:
Roth, M; Rogers, S; Roberts, S S; Boyle, John M; Müller, H J; Weber, W
Abstract:
We have used a monoclonal antibody specific for UV-induced 6-4 photoproducts in an ELISA assay to determine the kinetics of loss of antigenicity from the DNA of lymphocytes obtained from four groups of people; normal controls and cancer patients who had either received chemotherapy, hormone therapy or no treatment at all. This result was confirmed on a matched pairs analysis of 12 breast cancer patients sampled before and after chemotherapy. We conclude, that chemotherapeutic treatment with alkylating agents modulate the capacity of UV-induced DNA-repair in human lymphocytes in a yet unknown way.
Affiliation:
Department of Research, University Hospital Basel, Switzerland.
Citation:
Stimulation of UV-induced DNA excision repair by chemotherapeutic drugs in cancer patients., 14 (3A):809-15 Anticancer Res.
Journal:
Anticancer Research
Issue Date:
1994
URI:
http://hdl.handle.net/10541/97239
PubMed ID:
8074483
Type:
Article
Language:
en
ISSN:
0250-7005
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorRoth, Men
dc.contributor.authorRogers, Sen
dc.contributor.authorRoberts, S Sen
dc.contributor.authorBoyle, John Men
dc.contributor.authorMüller, H Jen
dc.contributor.authorWeber, Wen
dc.date.accessioned2010-04-23T10:13:09Z-
dc.date.available2010-04-23T10:13:09Z-
dc.date.issued1994-
dc.identifier.citationStimulation of UV-induced DNA excision repair by chemotherapeutic drugs in cancer patients., 14 (3A):809-15 Anticancer Res.en
dc.identifier.issn0250-7005-
dc.identifier.pmid8074483-
dc.identifier.urihttp://hdl.handle.net/10541/97239-
dc.description.abstractWe have used a monoclonal antibody specific for UV-induced 6-4 photoproducts in an ELISA assay to determine the kinetics of loss of antigenicity from the DNA of lymphocytes obtained from four groups of people; normal controls and cancer patients who had either received chemotherapy, hormone therapy or no treatment at all. This result was confirmed on a matched pairs analysis of 12 breast cancer patients sampled before and after chemotherapy. We conclude, that chemotherapeutic treatment with alkylating agents modulate the capacity of UV-induced DNA-repair in human lymphocytes in a yet unknown way.en
dc.language.isoenen
dc.subjectCanceren
dc.subject.meshAlkylating Agents-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshDNA-
dc.subject.meshDNA Repair-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLymphocytes-
dc.subject.meshMale-
dc.subject.meshNeoplasms-
dc.subject.meshUltraviolet Rays-
dc.titleStimulation of UV-induced DNA excision repair by chemotherapeutic drugs in cancer patients.en
dc.typeArticleen
dc.contributor.departmentDepartment of Research, University Hospital Basel, Switzerland.en
dc.identifier.journalAnticancer Researchen
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