2.50
Hdl Handle:
http://hdl.handle.net/10541/97213
Title:
Pubertal growth in young adult survivors of childhood leukemia.
Authors:
Didcock, E; Davies, H; Didi, Mohammed; Ogilvy-Stuart, Amanda L; Wales, J; Shalet, Stephen M
Abstract:
PURPOSE: To determine the effect of cranial irradiation (18 Gy and 24 Gy) on pubertal growth in young adult survivors of childhood acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: Final height (FH) and pubertal growth were retrospectively examined in 142 young adult survivors of childhood ALL. All were in first remission and had received either 18 or 24 Gy of cranial irradiation. Eighty-four children (48 girls) were treated with 24 Gy and 58 (35 girls) with 18 Gy. None had received either testicular or spinal irradiation. Timing and duration of puberty were studied in 110 patients. RESULTS: Significant reduction in height standard deviation score (SDS) from diagnosis to FH was seen in both sexes and in both dose groups. In girls, in both dose groups, mean age at peak height velocity (PHV) and mean age at menarche occurred significantly earlier than in the normal population. In boys, there was a normal timing of PHV. The amplitude of PHV was significantly reduced in both sexes and in both dose groups. Parameters of pubertal duration (PHV to menarche, PHV to FH, and menarche to FH) were not significantly different from normal population values. CONCLUSION: In conclusion, puberty occurred early in girls, but not in boys. Amplitude of PHV was reduced in both sexes, with no reduction in the duration of puberty. It is likely that disturbances of both timing and quality of growth during puberty contribute to the loss of standing height and body disproportion seen in these children.
Affiliation:
Department of Child Health, Queens Medical Centre, Nottingham, United Kingdom.
Citation:
Pubertal growth in young adult survivors of childhood leukemia. 1995, 13 (10):2503-7 J. Clin. Oncol.
Journal:
Journal of Clinical Oncology
Issue Date:
Oct-1995
URI:
http://hdl.handle.net/10541/97213
DOI:
10.1002/mpo.2950220407
PubMed ID:
7595700
Type:
Article
Language:
en
ISSN:
0732-183X
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorDidcock, Een
dc.contributor.authorDavies, Hen
dc.contributor.authorDidi, Mohammeden
dc.contributor.authorOgilvy-Stuart, Amanda Len
dc.contributor.authorWales, Jen
dc.contributor.authorShalet, Stephen Men
dc.date.accessioned2010-04-22T15:52:27Z-
dc.date.available2010-04-22T15:52:27Z-
dc.date.issued1995-10-
dc.identifier.citationPubertal growth in young adult survivors of childhood leukemia. 1995, 13 (10):2503-7 J. Clin. Oncol.en
dc.identifier.issn0732-183X-
dc.identifier.pmid7595700-
dc.identifier.doi10.1002/mpo.2950220407-
dc.identifier.urihttp://hdl.handle.net/10541/97213-
dc.description.abstractPURPOSE: To determine the effect of cranial irradiation (18 Gy and 24 Gy) on pubertal growth in young adult survivors of childhood acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: Final height (FH) and pubertal growth were retrospectively examined in 142 young adult survivors of childhood ALL. All were in first remission and had received either 18 or 24 Gy of cranial irradiation. Eighty-four children (48 girls) were treated with 24 Gy and 58 (35 girls) with 18 Gy. None had received either testicular or spinal irradiation. Timing and duration of puberty were studied in 110 patients. RESULTS: Significant reduction in height standard deviation score (SDS) from diagnosis to FH was seen in both sexes and in both dose groups. In girls, in both dose groups, mean age at peak height velocity (PHV) and mean age at menarche occurred significantly earlier than in the normal population. In boys, there was a normal timing of PHV. The amplitude of PHV was significantly reduced in both sexes and in both dose groups. Parameters of pubertal duration (PHV to menarche, PHV to FH, and menarche to FH) were not significantly different from normal population values. CONCLUSION: In conclusion, puberty occurred early in girls, but not in boys. Amplitude of PHV was reduced in both sexes, with no reduction in the duration of puberty. It is likely that disturbances of both timing and quality of growth during puberty contribute to the loss of standing height and body disproportion seen in these children.en
dc.language.isoenen
dc.subjectBrain Canceren
dc.subjectPrecursor Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subject.meshAdult-
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols-
dc.subject.meshAsparaginase-
dc.subject.meshBody Height-
dc.subject.meshBrain Neoplasms-
dc.subject.meshChild-
dc.subject.meshCombined Modality Therapy-
dc.subject.meshCranial Irradiation-
dc.subject.meshDaunorubicin-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshGrowth-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMenarche-
dc.subject.meshMethotrexate-
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma-
dc.subject.meshPrednisolone-
dc.subject.meshPuberty-
dc.subject.meshRadiotherapy-
dc.subject.meshRetrospective Studies-
dc.subject.meshSex Factors-
dc.subject.meshVincristine-
dc.titlePubertal growth in young adult survivors of childhood leukemia.en
dc.typeArticleen
dc.contributor.departmentDepartment of Child Health, Queens Medical Centre, Nottingham, United Kingdom.en
dc.identifier.journalJournal of Clinical Oncologyen

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