Leukemia, lymphoma, and related disorders in families of children diagnosed with Wilms' tumor.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97153
Title:
Leukemia, lymphoma, and related disorders in families of children diagnosed with Wilms' tumor.
Authors:
Hartley, Ann L; Birch, Jillian M; Harris, Martin; Blair, Val; Morris Jones, P H; Gattamaneni, Rao; Kelsey, Anna M
Abstract:
Leukemias and lymphomas occurring in a series of families with Wilms' tumor (WT) are described. One surviving case developed a large cell anaplastic Ki-1 lymphoma at age 20 years, and 23 second- and higher degree relatives were affected. In two instances leukemia/lymphoma occurred in the context of Li-Fraumeni syndrome (LFS) and two other families showed striking clusters of unusual and early-onset malignancies. In several cases, children had genitourinary abnormalities of the type associated with the WT1 gene on chromosome 11p13. Some of these families may provide important subjects for study of WT genes in hematologic disease and lymphomas and for investigation of interaction between different tumor-suppressor genes, e.g., WT1 and other candidate WT genes, and p53.
Affiliation:
CRC Paediatric and Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, England.
Citation:
Leukemia, lymphoma, and related disorders in families of children diagnosed with Wilms' tumor. 1994, 77 (2):129-33 Cancer Genet. Cytogenet.
Journal:
Cancer Genetics and Cytogenetics
Issue Date:
15-Oct-1994
URI:
http://hdl.handle.net/10541/97153
DOI:
10.1016/0165-4608(94)90228-3
PubMed ID:
7954323
Type:
Article
Language:
en
ISSN:
0165-4608
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHartley, Ann Len
dc.contributor.authorBirch, Jillian Men
dc.contributor.authorHarris, Martinen
dc.contributor.authorBlair, Valen
dc.contributor.authorMorris Jones, P Hen
dc.contributor.authorGattamaneni, Raoen
dc.contributor.authorKelsey, Anna Men
dc.date.accessioned2010-04-22T10:28:33Z-
dc.date.available2010-04-22T10:28:33Z-
dc.date.issued1994-10-15-
dc.identifier.citationLeukemia, lymphoma, and related disorders in families of children diagnosed with Wilms' tumor. 1994, 77 (2):129-33 Cancer Genet. Cytogenet.en
dc.identifier.issn0165-4608-
dc.identifier.pmid7954323-
dc.identifier.doi10.1016/0165-4608(94)90228-3-
dc.identifier.urihttp://hdl.handle.net/10541/97153-
dc.description.abstractLeukemias and lymphomas occurring in a series of families with Wilms' tumor (WT) are described. One surviving case developed a large cell anaplastic Ki-1 lymphoma at age 20 years, and 23 second- and higher degree relatives were affected. In two instances leukemia/lymphoma occurred in the context of Li-Fraumeni syndrome (LFS) and two other families showed striking clusters of unusual and early-onset malignancies. In several cases, children had genitourinary abnormalities of the type associated with the WT1 gene on chromosome 11p13. Some of these families may provide important subjects for study of WT genes in hematologic disease and lymphomas and for investigation of interaction between different tumor-suppressor genes, e.g., WT1 and other candidate WT genes, and p53.en
dc.language.isoenen
dc.subjectKidney Canceren
dc.subjectLeukaemiaen
dc.subjectWilms Tumouren
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshKidney Neoplasms-
dc.subject.meshLeukemia-
dc.subject.meshLymphoma-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshPedigree-
dc.subject.meshWilms Tumor-
dc.titleLeukemia, lymphoma, and related disorders in families of children diagnosed with Wilms' tumor.en
dc.typeArticleen
dc.contributor.departmentCRC Paediatric and Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, England.en
dc.identifier.journalCancer Genetics and Cytogeneticsen

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