Patterns and temporal trends in the incidence of malignant disease in children: II. Solid tumours of childhood.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97149
Title:
Patterns and temporal trends in the incidence of malignant disease in children: II. Solid tumours of childhood.
Authors:
Blair, Val; Birch, Jillian M
Abstract:
Incidence patterns and trends, in children, of individual types of non-reticulo-endothelial solid tumours and of all cancers combined (including leukaemia and lymphoma) were analysed. The study included 3360 cases diagnosed in residents under 15 years of age of the North Western Regional Health Authority area of England during 1954-1988. Log-linear modelling identified significant increases of juvenile astrocytoma (average quinquennial increase 15%) in males, of medulloblastoma (19%) and neuroblastoma (17%) in females, and of non-skin epithelial tumours (18%) overall, and a significant decrease of unspecified malignant neoplasms around 1974 by approximately 80%. The chi 2 trend test identified significant increases in gonadal germ cell tumours and skin cancers, and borderline significant increases in craniopharyngioma and hepatoblastoma. The incidence of all cancers combined increased significantly in those aged under 1 year (8%), 1-4 years (5%) and 10-14 years (8%). Age-sex patterns were similar to those in other Caucasian populations. Studies of incidence trends can provide the basis for investigations of the aetiology of childhood cancers.
Affiliation:
Cancer Research Campaign Paediatric and Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, U.K.
Citation:
Patterns and temporal trends in the incidence of malignant disease in children: II. Solid tumours of childhood. 1994, 30A (10):1498-511 Eur. J. Cancer
Journal:
European Journal of Cancer
Issue Date:
1994
URI:
http://hdl.handle.net/10541/97149
DOI:
10.1016/0959-8049(94)00275-A
PubMed ID:
7833109
Type:
Article
Language:
en
ISSN:
0959-8049
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorBlair, Valen
dc.contributor.authorBirch, Jillian Men
dc.date.accessioned2010-04-22T11:14:09Z-
dc.date.available2010-04-22T11:14:09Z-
dc.date.issued1994-
dc.identifier.citationPatterns and temporal trends in the incidence of malignant disease in children: II. Solid tumours of childhood. 1994, 30A (10):1498-511 Eur. J. Canceren
dc.identifier.issn0959-8049-
dc.identifier.pmid7833109-
dc.identifier.doi10.1016/0959-8049(94)00275-A-
dc.identifier.urihttp://hdl.handle.net/10541/97149-
dc.description.abstractIncidence patterns and trends, in children, of individual types of non-reticulo-endothelial solid tumours and of all cancers combined (including leukaemia and lymphoma) were analysed. The study included 3360 cases diagnosed in residents under 15 years of age of the North Western Regional Health Authority area of England during 1954-1988. Log-linear modelling identified significant increases of juvenile astrocytoma (average quinquennial increase 15%) in males, of medulloblastoma (19%) and neuroblastoma (17%) in females, and of non-skin epithelial tumours (18%) overall, and a significant decrease of unspecified malignant neoplasms around 1974 by approximately 80%. The chi 2 trend test identified significant increases in gonadal germ cell tumours and skin cancers, and borderline significant increases in craniopharyngioma and hepatoblastoma. The incidence of all cancers combined increased significantly in those aged under 1 year (8%), 1-4 years (5%) and 10-14 years (8%). Age-sex patterns were similar to those in other Caucasian populations. Studies of incidence trends can provide the basis for investigations of the aetiology of childhood cancers.en
dc.language.isoenen
dc.subjectBone Canceren
dc.subjectCanceren
dc.subjectCentral Nervous System Canceren
dc.subjectGerm Cell and Embryonal Canceren
dc.subjectSoft Tissue Canceren
dc.subject.meshAdolescent-
dc.subject.meshAge Factors-
dc.subject.meshBone Neoplasms-
dc.subject.meshCentral Nervous System Neoplasms-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshEngland-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIncidence-
dc.subject.meshInfant-
dc.subject.meshInfant, Newborn-
dc.subject.meshMale-
dc.subject.meshNeoplasms-
dc.subject.meshNeoplasms, Germ Cell and Embryonal-
dc.subject.meshRegistries-
dc.subject.meshRisk Factors-
dc.subject.meshSarcoma-
dc.subject.meshSex Factors-
dc.subject.meshSoft Tissue Neoplasms-
dc.titlePatterns and temporal trends in the incidence of malignant disease in children: II. Solid tumours of childhood.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Paediatric and Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, U.K.en
dc.identifier.journalEuropean Journal of Canceren

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