Patterns and temporal trends in the incidence of malignant disease in children: I. Leukaemia and lymphoma.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97144
Title:
Patterns and temporal trends in the incidence of malignant disease in children: I. Leukaemia and lymphoma.
Authors:
Blair, Val; Birch, Jillian M
Abstract:
Patterns and trends in incidence of leukaemia and lymphoma in children aged under 15 years and resident in the North Western Regional Health Authority area of England at diagnosis, over the 35-year time period 1954-1988, were analysed. The study included 1407 cases registered with the Manchester Children's Tumour Registry, 100% of which had a histologically or cytologically verified diagnosis. Log-linear modelling identified significant linear increases in acute lymphocytic leukaemia (ALL) (average quinquennial increase 4%) and Hodgkin's disease (HD) (10%), but not in acute non-lymphocytic leukaemia nor non-Hodgkin's lymphoma. Additionally, the chi 2 test for trend identified a significant increase in the incidence of chronic myeloid leukaemia. The possibility that the increases seen in ALL and HD are linked to increases in prevalence of unknown infectious agents is discussed.
Affiliation:
Cancer Research Campaign Paediatric and Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, U.K.
Citation:
Patterns and temporal trends in the incidence of malignant disease in children: I. Leukaemia and lymphoma. 1994, 30A (10):1490-8 Eur. J. Cancer
Journal:
European Journal of Cancer (Oxford, England : 1990)
Issue Date:
1994
URI:
http://hdl.handle.net/10541/97144
DOI:
10.1016/0959-8049(94)00274-9
PubMed ID:
7833108
Type:
Article
Language:
en
ISSN:
0959-8049
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorBlair, Valen
dc.contributor.authorBirch, Jillian Men
dc.date.accessioned2010-04-22T10:48:41Z-
dc.date.available2010-04-22T10:48:41Z-
dc.date.issued1994-
dc.identifier.citationPatterns and temporal trends in the incidence of malignant disease in children: I. Leukaemia and lymphoma. 1994, 30A (10):1490-8 Eur. J. Canceren
dc.identifier.issn0959-8049-
dc.identifier.pmid7833108-
dc.identifier.doi10.1016/0959-8049(94)00274-9-
dc.identifier.urihttp://hdl.handle.net/10541/97144-
dc.description.abstractPatterns and trends in incidence of leukaemia and lymphoma in children aged under 15 years and resident in the North Western Regional Health Authority area of England at diagnosis, over the 35-year time period 1954-1988, were analysed. The study included 1407 cases registered with the Manchester Children's Tumour Registry, 100% of which had a histologically or cytologically verified diagnosis. Log-linear modelling identified significant linear increases in acute lymphocytic leukaemia (ALL) (average quinquennial increase 4%) and Hodgkin's disease (HD) (10%), but not in acute non-lymphocytic leukaemia nor non-Hodgkin's lymphoma. Additionally, the chi 2 test for trend identified a significant increase in the incidence of chronic myeloid leukaemia. The possibility that the increases seen in ALL and HD are linked to increases in prevalence of unknown infectious agents is discussed.en
dc.language.isoenen
dc.subjectLeukaemiaen
dc.subjectAcute Myeloid Leukaemiaen
dc.subjectLeukaemia, Myelogenous, Chronic, BCR-ABL Positiveen
dc.subjectPrecursor Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subject.meshAdolescent-
dc.subject.meshAge Factors-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshEngland-
dc.subject.meshFemale-
dc.subject.meshHodgkin Disease-
dc.subject.meshHumans-
dc.subject.meshIncidence-
dc.subject.meshInfant-
dc.subject.meshInfant, Newborn-
dc.subject.meshLeukemia-
dc.subject.meshLeukemia, Myelogenous, Chronic, BCR-ABL Positive-
dc.subject.meshLeukemia, Myeloid, Acute-
dc.subject.meshLymphoma-
dc.subject.meshLymphoma, Non-Hodgkin-
dc.subject.meshMale-
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma-
dc.subject.meshRegistries-
dc.subject.meshSex Factors-
dc.subject.meshTime Factors-
dc.titlePatterns and temporal trends in the incidence of malignant disease in children: I. Leukaemia and lymphoma.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Paediatric and Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, U.K.en
dc.identifier.journalEuropean Journal of Cancer (Oxford, England : 1990)en

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