Malformations in children with soft tissue sarcoma and in their parents and siblings.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97140
Title:
Malformations in children with soft tissue sarcoma and in their parents and siblings.
Authors:
Hartley, Ann L; Birch, Jillian M; Blair, Val; Kelsey, Anna M
Abstract:
The presence of malformations in a population-based series of 181 children diagnosed with soft tissue sarcoma and in the majority of their parents and siblings was ascertained from family interviews and medical records. Five index children (2.8%) had serious anomalies, a figure not in excess of that derived from general population data. Fourteen siblings (4%) were affected, and higher rates of malformations were seen in siblings of female case children (P = 0.06) and siblings of children with visceral tumours (P = 0.03). There was no correlation between site of tumour in the index and specific organ system anomalies in the index or in their respective siblings. The survey indicated that there are unlikely to be strong associations between childhood soft tissue sarcoma and major malformations, a situation distinct from that found in Wilms' tumour.
Affiliation:
Cancer Research Campaign Paediatric and Familial Cancer Research Group, Christie Hospital, Manchester, UK.
Citation:
Malformations in children with soft tissue sarcoma and in their parents and siblings. 1994, 8 (4):423-32 Paediatr Perinat Epidemiol
Journal:
Paediatric and Perinatal Epidemiology
Issue Date:
Oct-1994
URI:
http://hdl.handle.net/10541/97140
DOI:
10.1111/j.1365-3016.1994.tb00481.x
PubMed ID:
7870626
Type:
Article
Language:
en
ISSN:
0269-5022
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHartley, Ann Len
dc.contributor.authorBirch, Jillian Men
dc.contributor.authorBlair, Valen
dc.contributor.authorKelsey, Anna Men
dc.date.accessioned2010-04-22T09:48:49Z-
dc.date.available2010-04-22T09:48:49Z-
dc.date.issued1994-10-
dc.identifier.citationMalformations in children with soft tissue sarcoma and in their parents and siblings. 1994, 8 (4):423-32 Paediatr Perinat Epidemiolen
dc.identifier.issn0269-5022-
dc.identifier.pmid7870626-
dc.identifier.doi10.1111/j.1365-3016.1994.tb00481.x-
dc.identifier.urihttp://hdl.handle.net/10541/97140-
dc.description.abstractThe presence of malformations in a population-based series of 181 children diagnosed with soft tissue sarcoma and in the majority of their parents and siblings was ascertained from family interviews and medical records. Five index children (2.8%) had serious anomalies, a figure not in excess of that derived from general population data. Fourteen siblings (4%) were affected, and higher rates of malformations were seen in siblings of female case children (P = 0.06) and siblings of children with visceral tumours (P = 0.03). There was no correlation between site of tumour in the index and specific organ system anomalies in the index or in their respective siblings. The survey indicated that there are unlikely to be strong associations between childhood soft tissue sarcoma and major malformations, a situation distinct from that found in Wilms' tumour.en
dc.language.isoenen
dc.subject.meshAdolescent-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshCongenital Abnormalities-
dc.subject.meshEngland-
dc.subject.meshFamily Health-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIncidence-
dc.subject.meshInfant-
dc.subject.meshMale-
dc.subject.meshSarcoma-
dc.subject.meshSeverity of Illness Index-
dc.titleMalformations in children with soft tissue sarcoma and in their parents and siblings.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Paediatric and Familial Cancer Research Group, Christie Hospital, Manchester, UK.en
dc.identifier.journalPaediatric and Perinatal Epidemiologyen

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