Lipid-rich residual bodies in the human thyroid gland: ultrastructural, histochemical, and morphometric study.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97136
Title:
Lipid-rich residual bodies in the human thyroid gland: ultrastructural, histochemical, and morphometric study.
Authors:
Yamazaki, K; Eyden, Brian P
Abstract:
Eleven samples of surgical and autopsy thyroid tissue were studied by classical histology, histochemistry, immunohistochemistry, light microscope quantitation and transmission electron microscopy in order to characterize lipid-rich residual bodies (LRRBs) previously reported in human myometrium. The following observations were made: 1) LRRBs were found largely in follicular epithelial cells; 2) they had exactly the same histochemical, immunohistochemical and ultrastructural characteristics as LRRBs from myometrium; 3) they had a distinctive distribution and morphology compared with lipofuscin; 4) a lysosomal nature was confirmed by their content of acid phosphatase and cathepsin D; 5) they were virtually absent from both the new-born thyroid and from thyroid carcinoma; 6) there was a statistical linear correlation between LRRB frequency and patient age. In conclusion, LRRBs have been demonstrated in an extra-uterine location, and are confirmed as residual lysosomes, probably having been involved in lipid metabolism.
Affiliation:
Department of Pathology, School of Medicine Keio University, Tokyo, Japan.
Citation:
Lipid-rich residual bodies in the human thyroid gland: ultrastructural, histochemical, and morphometric study. 1994, 26 (4):553-63 J. Submicrosc. Cytol. Pathol.
Journal:
Journal of Submicroscopic Cytology and Pathology
Issue Date:
Oct-1994
URI:
http://hdl.handle.net/10541/97136
PubMed ID:
7820818
Type:
Article
Language:
en
ISSN:
1122-9497
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorYamazaki, Ken
dc.contributor.authorEyden, Brian Pen
dc.date.accessioned2010-04-22T09:39:11Z-
dc.date.available2010-04-22T09:39:11Z-
dc.date.issued1994-10-
dc.identifier.citationLipid-rich residual bodies in the human thyroid gland: ultrastructural, histochemical, and morphometric study. 1994, 26 (4):553-63 J. Submicrosc. Cytol. Pathol.en
dc.identifier.issn1122-9497-
dc.identifier.pmid7820818-
dc.identifier.urihttp://hdl.handle.net/10541/97136-
dc.description.abstractEleven samples of surgical and autopsy thyroid tissue were studied by classical histology, histochemistry, immunohistochemistry, light microscope quantitation and transmission electron microscopy in order to characterize lipid-rich residual bodies (LRRBs) previously reported in human myometrium. The following observations were made: 1) LRRBs were found largely in follicular epithelial cells; 2) they had exactly the same histochemical, immunohistochemical and ultrastructural characteristics as LRRBs from myometrium; 3) they had a distinctive distribution and morphology compared with lipofuscin; 4) a lysosomal nature was confirmed by their content of acid phosphatase and cathepsin D; 5) they were virtually absent from both the new-born thyroid and from thyroid carcinoma; 6) there was a statistical linear correlation between LRRB frequency and patient age. In conclusion, LRRBs have been demonstrated in an extra-uterine location, and are confirmed as residual lysosomes, probably having been involved in lipid metabolism.en
dc.language.isoenen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAging-
dc.subject.meshCathepsin D-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshInfant, Newborn-
dc.subject.meshLipid Metabolism-
dc.subject.meshLipofuscin-
dc.subject.meshLysosomes-
dc.subject.meshMale-
dc.subject.meshMicroscopy, Electron-
dc.subject.meshMiddle Aged-
dc.subject.meshPhosphoric Monoester Hydrolases-
dc.subject.meshThyroid Gland-
dc.titleLipid-rich residual bodies in the human thyroid gland: ultrastructural, histochemical, and morphometric study.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, School of Medicine Keio University, Tokyo, Japan.en
dc.identifier.journalJournal of Submicroscopic Cytology and Pathologyen
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