Foetal loss and infant deaths in families of children with soft-tissue sarcoma.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97079
Title:
Foetal loss and infant deaths in families of children with soft-tissue sarcoma.
Authors:
Hartley, Ann L; Birch, Jillian M; Blair, Val; Kelsey, Anna M; Morris Jones, P H
Abstract:
Distribution of miscarriages, stillbirths and infant deaths in the families of a population-based series of children with soft-tissue sarcoma was examined in relation to index case histology (rhabdomyosarcoma or other soft-tissue sarcoma) and to the possible presence of genetic predisposition to cancer in the families (Li-Fraumeni syndrome or neurofibromatosis). Reproductive loss was not related to index histology (miscarriages, p = 0.3; all losses, p = 0.6) but was significantly higher in "genetic" rather than "sporadic" families (miscarriages, p = 0.02; all losses, p = 0.01). However, excess reproductive loss was not a feature of families with the Li-Fraumeni syndrome, but appeared to be concentrated in the families affected by neurofibromatosis.
Affiliation:
CRC Paediatric and Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Foetal loss and infant deaths in families of children with soft-tissue sarcoma. 1994, 56 (5):646-9 Int. J. Cancer
Journal:
International Journal of Cancer
Issue Date:
1-Mar-1994
URI:
http://hdl.handle.net/10541/97079
DOI:
10.1002/ijc.2910560507
PubMed ID:
8314340
Type:
Article
Language:
en
ISSN:
0020-7136
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHartley, Ann Len
dc.contributor.authorBirch, Jillian Men
dc.contributor.authorBlair, Valen
dc.contributor.authorKelsey, Anna Men
dc.contributor.authorMorris Jones, P Hen
dc.date.accessioned2010-04-21T13:59:50Z-
dc.date.available2010-04-21T13:59:50Z-
dc.date.issued1994-03-01-
dc.identifier.citationFoetal loss and infant deaths in families of children with soft-tissue sarcoma. 1994, 56 (5):646-9 Int. J. Canceren
dc.identifier.issn0020-7136-
dc.identifier.pmid8314340-
dc.identifier.doi10.1002/ijc.2910560507-
dc.identifier.urihttp://hdl.handle.net/10541/97079-
dc.description.abstractDistribution of miscarriages, stillbirths and infant deaths in the families of a population-based series of children with soft-tissue sarcoma was examined in relation to index case histology (rhabdomyosarcoma or other soft-tissue sarcoma) and to the possible presence of genetic predisposition to cancer in the families (Li-Fraumeni syndrome or neurofibromatosis). Reproductive loss was not related to index histology (miscarriages, p = 0.3; all losses, p = 0.6) but was significantly higher in "genetic" rather than "sporadic" families (miscarriages, p = 0.02; all losses, p = 0.01). However, excess reproductive loss was not a feature of families with the Li-Fraumeni syndrome, but appeared to be concentrated in the families affected by neurofibromatosis.en
dc.language.isoenen
dc.subjectSoft Tissue Canceren
dc.subjectFoetal Deathen
dc.subject.meshAbortion, Spontaneous-
dc.subject.meshAdolescent-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshDisease Susceptibility-
dc.subject.meshFamily-
dc.subject.meshFemale-
dc.subject.meshFetal Death-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshInfant Mortality-
dc.subject.meshInfant, Newborn-
dc.subject.meshLi-Fraumeni Syndrome-
dc.subject.meshMaternal Age-
dc.subject.meshNeurofibromatoses-
dc.subject.meshPregnancy-
dc.subject.meshRhabdomyosarcoma-
dc.subject.meshSarcoma-
dc.subject.meshSoft Tissue Neoplasms-
dc.titleFoetal loss and infant deaths in families of children with soft-tissue sarcoma.en
dc.typeArticleen
dc.contributor.departmentCRC Paediatric and Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalInternational Journal of Canceren

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