Cutaneous epithelioid angiosarcoma: a clinicopathological study of four cases.
Affiliation
Department of Pathology, Bolton General Hospital, UK.Issue Date
1994-11
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Four cases of cutaneous epithelioid angiosarcoma are described together with the potential diagnostic trap of mistaking these tumours for poorly differentiated carcinoma or malignant melanoma. The immunophenotypic profile using four endothelial markers showed positive staining in all cases for factor VIII related antigen in a predominantly paranuclear dot-like fashion and for CD31 (JC70); in three cases for CD34 (QB-END/10) and in two cases with UEA-1. All four cases were cytokeratin (CAM 5.2 and AE1/AE3) negative in contrast to the positive staining reported at non-cutaneous sites. Aberrant S-100 protein expression was seen in one case. In two cases subsequent recurrences showed better differentiation than the original tumour. Electronmicroscopy confirmed the absence of non-endothelial lines of differentiation but failed to reveal Weibel-Palade bodies.Citation
Cutaneous epithelioid angiosarcoma: a clinicopathological study of four cases. 1994, 25 (5):421-9 HistopathologyJournal
HistopathologyDOI
10.1111/j.1365-2559.1994.tb00003.xPubMed ID
7868082Type
ArticleLanguage
enISSN
0309-0167ae974a485f413a2113503eed53cd6c53
10.1111/j.1365-2559.1994.tb00003.x
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