Cutaneous epithelioid angiosarcoma: a clinicopathological study of four cases.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97075
Title:
Cutaneous epithelioid angiosarcoma: a clinicopathological study of four cases.
Authors:
Prescott, R J; Banerjee, Saumitra S; Eyden, Brian P; Haboubi, N Y
Abstract:
Four cases of cutaneous epithelioid angiosarcoma are described together with the potential diagnostic trap of mistaking these tumours for poorly differentiated carcinoma or malignant melanoma. The immunophenotypic profile using four endothelial markers showed positive staining in all cases for factor VIII related antigen in a predominantly paranuclear dot-like fashion and for CD31 (JC70); in three cases for CD34 (QB-END/10) and in two cases with UEA-1. All four cases were cytokeratin (CAM 5.2 and AE1/AE3) negative in contrast to the positive staining reported at non-cutaneous sites. Aberrant S-100 protein expression was seen in one case. In two cases subsequent recurrences showed better differentiation than the original tumour. Electronmicroscopy confirmed the absence of non-endothelial lines of differentiation but failed to reveal Weibel-Palade bodies.
Affiliation:
Department of Pathology, Bolton General Hospital, UK.
Citation:
Cutaneous epithelioid angiosarcoma: a clinicopathological study of four cases. 1994, 25 (5):421-9 Histopathology
Journal:
Histopathology
Issue Date:
Nov-1994
URI:
http://hdl.handle.net/10541/97075
DOI:
10.1111/j.1365-2559.1994.tb00003.x
PubMed ID:
7868082
Type:
Article
Language:
en
ISSN:
0309-0167
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorPrescott, R Jen
dc.contributor.authorBanerjee, Saumitra Sen
dc.contributor.authorEyden, Brian Pen
dc.contributor.authorHaboubi, N Yen
dc.date.accessioned2010-04-21T13:44:18Z-
dc.date.available2010-04-21T13:44:18Z-
dc.date.issued1994-11-
dc.identifier.citationCutaneous epithelioid angiosarcoma: a clinicopathological study of four cases. 1994, 25 (5):421-9 Histopathologyen
dc.identifier.issn0309-0167-
dc.identifier.pmid7868082-
dc.identifier.doi10.1111/j.1365-2559.1994.tb00003.x-
dc.identifier.urihttp://hdl.handle.net/10541/97075-
dc.description.abstractFour cases of cutaneous epithelioid angiosarcoma are described together with the potential diagnostic trap of mistaking these tumours for poorly differentiated carcinoma or malignant melanoma. The immunophenotypic profile using four endothelial markers showed positive staining in all cases for factor VIII related antigen in a predominantly paranuclear dot-like fashion and for CD31 (JC70); in three cases for CD34 (QB-END/10) and in two cases with UEA-1. All four cases were cytokeratin (CAM 5.2 and AE1/AE3) negative in contrast to the positive staining reported at non-cutaneous sites. Aberrant S-100 protein expression was seen in one case. In two cases subsequent recurrences showed better differentiation than the original tumour. Electronmicroscopy confirmed the absence of non-endothelial lines of differentiation but failed to reveal Weibel-Palade bodies.en
dc.language.isoenen
dc.subjectSkin Canceren
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshEpithelium-
dc.subject.meshFemale-
dc.subject.meshHemangiosarcoma-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshSkin Neoplasms-
dc.titleCutaneous epithelioid angiosarcoma: a clinicopathological study of four cases.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, Bolton General Hospital, UK.en
dc.identifier.journalHistopathologyen

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