Genitourinary tumors in the families of children with renal tumors.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97063
Title:
Genitourinary tumors in the families of children with renal tumors.
Authors:
Hartley, Ann L; Birch, Jillian M; Blair, Val; Kelsey, Anna M; Harris, Martin; Jones, P H; Gattamaneni, Rao
Abstract:
The occurrence of genitourinary tumors in the relatives of a population-based series of 218 children diagnosed with renal tumors was investigated. Family data on 92% (176 of 192) of Wilms' tumor (WT) patients and 77% (20 of 26) of other renal tumor patients were obtained. In all, 21 genitourinary tumors in first-degree relatives in 19 families were ascertained, together with 30 such tumors in second-degree relatives. Ten families were diagnosed with multiple genitourinary tumors, although none of these manifested familial WT. It is proposed that a small proportion of families of children with renal tumors has a genetic predisposition to develop genitourinary tumors and that these tumors may represent further manifestations of the pleiotropic effects of the WT1 gene or of other genes involved in WT predisposition.
Affiliation:
CRC Paediatric and Familial Cancer Research Group, Christie Hospital Trust, Manchester, England.
Citation:
Genitourinary tumors in the families of children with renal tumors. 1994, 72 (1):28-32 Cancer Genet. Cytogenet.
Journal:
Cancer Genetics and Cytogenetics
Issue Date:
Jan-1994
URI:
http://hdl.handle.net/10541/97063
DOI:
10.1016/0165-4608(94)90105-8
PubMed ID:
8111735
Type:
Article
Language:
en
ISSN:
0165-4608
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHartley, Ann Len
dc.contributor.authorBirch, Jillian Men
dc.contributor.authorBlair, Valen
dc.contributor.authorKelsey, Anna Men
dc.contributor.authorHarris, Martinen
dc.contributor.authorJones, P Hen
dc.contributor.authorGattamaneni, Raoen
dc.date.accessioned2010-04-21T14:10:20Z-
dc.date.available2010-04-21T14:10:20Z-
dc.date.issued1994-01-
dc.identifier.citationGenitourinary tumors in the families of children with renal tumors. 1994, 72 (1):28-32 Cancer Genet. Cytogenet.en
dc.identifier.issn0165-4608-
dc.identifier.pmid8111735-
dc.identifier.doi10.1016/0165-4608(94)90105-8-
dc.identifier.urihttp://hdl.handle.net/10541/97063-
dc.description.abstractThe occurrence of genitourinary tumors in the relatives of a population-based series of 218 children diagnosed with renal tumors was investigated. Family data on 92% (176 of 192) of Wilms' tumor (WT) patients and 77% (20 of 26) of other renal tumor patients were obtained. In all, 21 genitourinary tumors in first-degree relatives in 19 families were ascertained, together with 30 such tumors in second-degree relatives. Ten families were diagnosed with multiple genitourinary tumors, although none of these manifested familial WT. It is proposed that a small proportion of families of children with renal tumors has a genetic predisposition to develop genitourinary tumors and that these tumors may represent further manifestations of the pleiotropic effects of the WT1 gene or of other genes involved in WT predisposition.en
dc.language.isoenen
dc.subjectWilms Tumouren
dc.subjectWilms Tumour Genesen
dc.subjectKidney Canceren
dc.subjectMultiple Primary Canceren
dc.subjectUrogenital Canceren
dc.subject.meshAdult-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshFemale-
dc.subject.meshGenes, Wilms Tumor-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshKaryotyping-
dc.subject.meshKidney Neoplasms-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasms, Multiple Primary-
dc.subject.meshUrogenital Neoplasms-
dc.subject.meshWilms Tumor-
dc.titleGenitourinary tumors in the families of children with renal tumors.en
dc.typeArticleen
dc.contributor.departmentCRC Paediatric and Familial Cancer Research Group, Christie Hospital Trust, Manchester, England.en
dc.identifier.journalCancer Genetics and Cytogeneticsen

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