2.50
Hdl Handle:
http://hdl.handle.net/10541/97058
Title:
Cranial irradiation and early puberty.
Authors:
Ogilvy-Stuart, Amanda L; Clayton, Peter E; Shalet, Stephen M
Abstract:
Low doses of cranial irradiation (18-24 gray) employed in the management of acute lymphoblastic leukemia may cause early or precocious puberty, predominantly in girls. To determine whether this sexual dichotomy exists at higher irradiation doses (25-47 gray), the onset of puberty was identified in 46 GH-deficient children (30 males) previously irradiated for a brain tumor not involving the hypothalamic-pituitary axis and compared with the normal pubertal standards of Marshall and Tanner. Age at irradiation was at least 2 SD below the mean age of pubertal onset in normal children. There was a significant linear association between age at irradiation and age at onset of puberty. The onset of puberty occurred at an early age in both sexes (mean, 8.51 yr in girls and 9.21 yr in boys plus 0.29 yr for every year of age at irradiation). For example, the estimated age at onset of puberty in a boy irradiated at 2 yr of age would be 9.79 yr, and that for a boy irradiated at 9 yr of age would be 11.82 yr. In the context of GH deficiency, which is usually associated with a delay in the onset of puberty, this is abnormal. At each age of irradiation, the estimated age at the onset of puberty was approximately 0.7 yr earlier in girls than boys. A similar trend was seen for bone age, which was abnormally early at the time of pubertal onset (mean, 7.39 yr in girls and 8.66 yr in boys plus 0.25 yr for every year of age at the time of irradiation). At the doses of irradiation employed in the treatment of brain tumors, radiation-induced early puberty is not restricted to girls. The clinical consequence of early puberty in the management of poor growth associated with radiation-induced GH deficiency is to foreshorten the time available for treatment with GH.
Affiliation:
Department of Endocrinology, Christie Hospital, Manchester, United Kingdom.
Citation:
Cranial irradiation and early puberty. 1994, 78 (6):1282-6 J. Clin. Endocrinol. Metab.
Journal:
The Journal of Clinical Endocrinology and Metabolism
Issue Date:
Jun-1994
URI:
http://hdl.handle.net/10541/97058
PubMed ID:
8200926
Type:
Article
Language:
en
ISSN:
0021-972X
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorOgilvy-Stuart, Amanda Len
dc.contributor.authorClayton, Peter Een
dc.contributor.authorShalet, Stephen Men
dc.date.accessioned2010-04-21T13:48:50Z-
dc.date.available2010-04-21T13:48:50Z-
dc.date.issued1994-06-
dc.identifier.citationCranial irradiation and early puberty. 1994, 78 (6):1282-6 J. Clin. Endocrinol. Metab.en
dc.identifier.issn0021-972X-
dc.identifier.pmid8200926-
dc.identifier.urihttp://hdl.handle.net/10541/97058-
dc.description.abstractLow doses of cranial irradiation (18-24 gray) employed in the management of acute lymphoblastic leukemia may cause early or precocious puberty, predominantly in girls. To determine whether this sexual dichotomy exists at higher irradiation doses (25-47 gray), the onset of puberty was identified in 46 GH-deficient children (30 males) previously irradiated for a brain tumor not involving the hypothalamic-pituitary axis and compared with the normal pubertal standards of Marshall and Tanner. Age at irradiation was at least 2 SD below the mean age of pubertal onset in normal children. There was a significant linear association between age at irradiation and age at onset of puberty. The onset of puberty occurred at an early age in both sexes (mean, 8.51 yr in girls and 9.21 yr in boys plus 0.29 yr for every year of age at irradiation). For example, the estimated age at onset of puberty in a boy irradiated at 2 yr of age would be 9.79 yr, and that for a boy irradiated at 9 yr of age would be 11.82 yr. In the context of GH deficiency, which is usually associated with a delay in the onset of puberty, this is abnormal. At each age of irradiation, the estimated age at the onset of puberty was approximately 0.7 yr earlier in girls than boys. A similar trend was seen for bone age, which was abnormally early at the time of pubertal onset (mean, 7.39 yr in girls and 8.66 yr in boys plus 0.25 yr for every year of age at the time of irradiation). At the doses of irradiation employed in the treatment of brain tumors, radiation-induced early puberty is not restricted to girls. The clinical consequence of early puberty in the management of poor growth associated with radiation-induced GH deficiency is to foreshorten the time available for treatment with GH.en
dc.language.isoenen
dc.subjectBrain Canceren
dc.subjectCerebellar Canceren
dc.subject.meshAge Factors-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshAstrocytoma-
dc.subject.meshBrain Neoplasms-
dc.subject.meshCerebellar Neoplasms-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshCombined Modality Therapy-
dc.subject.meshEpendymoma-
dc.subject.meshFemale-
dc.subject.meshGlioma-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMedulloblastoma-
dc.subject.meshProbability-
dc.subject.meshPuberty, Precocious-
dc.subject.meshRadiation Injuries-
dc.subject.meshRadiotherapy-
dc.subject.meshRegression Analysis-
dc.subject.meshSex Factors-
dc.titleCranial irradiation and early puberty.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital, Manchester, United Kingdom.en
dc.identifier.journalThe Journal of Clinical Endocrinology and Metabolismen

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