Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97056
Title:
Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy.
Authors:
Cuzick, J; Stewart, H; Rutqvist, L; Houghton, J; Edwards, R; Redmond, C; Peto, R; Baum, Michael; Fisher, B; Host, H
Abstract:
PURPOSE: To examine long-term cause-specific mortality in patients irradiated for breast cancer as part of a randomized clinical trial. PATIENTS AND METHODS: We studied all available information from randomized trials initiated before 1975 in which radiotherapy was the randomized option and surgery was the same for both treatment arms. Eight such trials were identified. RESULTS: The increased all-cause mortality rate in 10-year survivors previously reported is no longer significant, although a numerical difference in favor of non-irradiated patients remains. This result was strongly influenced by the earliest trials, and more recent trials have found a nonsignificant net benefit in overall mortality associated with radiation therapy. An excess of cardiac deaths was apparent in both early and more recent trials (P < .001), but this was offset by a reduced number of deaths due to breast cancer, especially in more recent trials. CONCLUSION: The reduction of breast cancer deaths suggests that radiation therapy may have a value beyond the clearly established improvements obtainable for local control. Use of techniques that minimize cardiac dose is important in reducing the risks of adjuvant radiotherapy, especially in good-prognosis patients.
Affiliation:
Imperial Cancer Research Fund, London, United Kingdom.
Citation:
Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy. 1994, 12 (3):447-53 J. Clin. Oncol.
Journal:
Journal of Clinical Oncology
Issue Date:
Mar-1994
URI:
http://hdl.handle.net/10541/97056
PubMed ID:
8120544
Type:
Article
Language:
en
ISSN:
0732-183X
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorCuzick, Jen
dc.contributor.authorStewart, Hen
dc.contributor.authorRutqvist, Len
dc.contributor.authorHoughton, Jen
dc.contributor.authorEdwards, Ren
dc.contributor.authorRedmond, Cen
dc.contributor.authorPeto, Ren
dc.contributor.authorBaum, Michaelen
dc.contributor.authorFisher, Ben
dc.contributor.authorHost, Hen
dc.date.accessioned2010-04-21T13:35:02Z-
dc.date.available2010-04-21T13:35:02Z-
dc.date.issued1994-03-
dc.identifier.citationCause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy. 1994, 12 (3):447-53 J. Clin. Oncol.en
dc.identifier.issn0732-183X-
dc.identifier.pmid8120544-
dc.identifier.urihttp://hdl.handle.net/10541/97056-
dc.description.abstractPURPOSE: To examine long-term cause-specific mortality in patients irradiated for breast cancer as part of a randomized clinical trial. PATIENTS AND METHODS: We studied all available information from randomized trials initiated before 1975 in which radiotherapy was the randomized option and surgery was the same for both treatment arms. Eight such trials were identified. RESULTS: The increased all-cause mortality rate in 10-year survivors previously reported is no longer significant, although a numerical difference in favor of non-irradiated patients remains. This result was strongly influenced by the earliest trials, and more recent trials have found a nonsignificant net benefit in overall mortality associated with radiation therapy. An excess of cardiac deaths was apparent in both early and more recent trials (P < .001), but this was offset by a reduced number of deaths due to breast cancer, especially in more recent trials. CONCLUSION: The reduction of breast cancer deaths suggests that radiation therapy may have a value beyond the clearly established improvements obtainable for local control. Use of techniques that minimize cardiac dose is important in reducing the risks of adjuvant radiotherapy, especially in good-prognosis patients.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subject.meshBreast Neoplasms-
dc.subject.meshCause of Death-
dc.subject.meshCombined Modality Therapy-
dc.subject.meshEurope-
dc.subject.meshFemale-
dc.subject.meshHeart Diseases-
dc.subject.meshHumans-
dc.subject.meshMiddle Aged-
dc.subject.meshRadiotherapy-
dc.subject.meshRandomized Controlled Trials as Topic-
dc.subject.meshSurvival Rate-
dc.titleCause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy.en
dc.typeArticleen
dc.contributor.departmentImperial Cancer Research Fund, London, United Kingdom.en
dc.identifier.journalJournal of Clinical Oncologyen

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