Carcinosarcoma of the ovary treated over a 10-year period at the Christie Hospital.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97028
Title:
Carcinosarcoma of the ovary treated over a 10-year period at the Christie Hospital.
Authors:
Prendiville, Joseph A; Murphy, D; Renninson, J; Buckley, H; Crowther, Derek
Abstract:
Carcinosarcomas (previously termed malignant mixed Müllerian tumors) are highly malignant but rare tumors of the ovary. Most patients have been treated according to a wide variety of protocols for soft tissue sarcoma or for epithelial ovarian carcinoma and as a result the optimal treatment for this neoplasm is unknown. We describe here 20 patients with this ovarian tumor (15 with heterologous sarcomatous elements and five with homologous sarcomatous elements) referred to our institute. Five patients were treated with surgery alone, two patients with chemotherapy alone and 13 patients with a combination of surgery and chemotherapy. A variety of chemotherapeutic regimens were used reflecting the 10-year time span it took to accrue these patients. Forty-five per cent of all patients died within 1 year of initial surgery and there was a median survival of 14 months. Two patients achieved a complete remission following treatment with 10 cycles of intravenous cyclophosphamide and are still alive at 103 and 106 months follow-up. We suggest that a chemotherapy regimen combining cyclophosphamide and a platinum analog may be useful for the management of patients with carcinosarcoma of the ovary requiring further therapy following surgery.
Affiliation:
CRC Department of Medical Oncology, Christie Hospital & Holt Radium Institute, Wilmslow Road,Department of Reproductive Pathology, St Mary's Hospital, Oxford Road, Manchester, UK.
Citation:
Carcinosarcoma of the ovary treated over a 10-year period at the Christie Hospital. 1994, 4 (3):200-205 Int. J. Gynecol. Cancer
Journal:
International Journal of Gynecological Cancer
Issue Date:
May-1994
URI:
http://hdl.handle.net/10541/97028
DOI:
10.1046/j.1525-1438.1994.04030200.x
PubMed ID:
11578407
Type:
Article
Language:
en
ISSN:
1525-1438
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorPrendiville, Joseph Aen
dc.contributor.authorMurphy, Den
dc.contributor.authorRenninson, Jen
dc.contributor.authorBuckley, Hen
dc.contributor.authorCrowther, Dereken
dc.date.accessioned2010-04-21T11:13:01Z-
dc.date.available2010-04-21T11:13:01Z-
dc.date.issued1994-05-
dc.identifier.citationCarcinosarcoma of the ovary treated over a 10-year period at the Christie Hospital. 1994, 4 (3):200-205 Int. J. Gynecol. Canceren
dc.identifier.issn1525-1438-
dc.identifier.pmid11578407-
dc.identifier.doi10.1046/j.1525-1438.1994.04030200.x-
dc.identifier.urihttp://hdl.handle.net/10541/97028-
dc.description.abstractCarcinosarcomas (previously termed malignant mixed Müllerian tumors) are highly malignant but rare tumors of the ovary. Most patients have been treated according to a wide variety of protocols for soft tissue sarcoma or for epithelial ovarian carcinoma and as a result the optimal treatment for this neoplasm is unknown. We describe here 20 patients with this ovarian tumor (15 with heterologous sarcomatous elements and five with homologous sarcomatous elements) referred to our institute. Five patients were treated with surgery alone, two patients with chemotherapy alone and 13 patients with a combination of surgery and chemotherapy. A variety of chemotherapeutic regimens were used reflecting the 10-year time span it took to accrue these patients. Forty-five per cent of all patients died within 1 year of initial surgery and there was a median survival of 14 months. Two patients achieved a complete remission following treatment with 10 cycles of intravenous cyclophosphamide and are still alive at 103 and 106 months follow-up. We suggest that a chemotherapy regimen combining cyclophosphamide and a platinum analog may be useful for the management of patients with carcinosarcoma of the ovary requiring further therapy following surgery.en
dc.languageENG-
dc.language.isoenen
dc.subjectCarcinomaen
dc.subjectCarcinosarcomaen
dc.subjectChemotherapyen
dc.subjectOvary Sarcomaen
dc.titleCarcinosarcoma of the ovary treated over a 10-year period at the Christie Hospital.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Medical Oncology, Christie Hospital & Holt Radium Institute, Wilmslow Road,Department of Reproductive Pathology, St Mary's Hospital, Oxford Road, Manchester, UK.en
dc.identifier.journalInternational Journal of Gynecological Canceren

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