Acute lymphoblastic leukaemia following Hodgkin's disease is associated with a good prognosis.

2.50
Hdl Handle:
http://hdl.handle.net/10541/97013
Title:
Acute lymphoblastic leukaemia following Hodgkin's disease is associated with a good prognosis.
Authors:
Narayanan, M N; Morgenstern, Godfrey R; Chang, James; Harrison, Christine J; Ranson, Malcolm R; Scarffe, J Howard
Abstract:
Acute leukaemia, both myeloid and lymphoblastic, in patients treated for Hodgkin's disease (HD) is thought to have a poor prognosis. We report four adults who developed secondary acute lymphoblastic leukaemia (ALL) following chemoradiotherapy for HD. The chromosomal translocation t(4;11) (q21;q23) was found in two patients who received a chemotherapeutic regimen containing the DNA topoisomerase II inhibitor etoposide. Three of the four patients are alive and in unmaintained first remission at 3, 5 and 9 years from diagnosis of ALL, two following autologous bone marrow transplantation. These results suggest that ALL following HD may have a good prognosis when treated aggressively.
Affiliation:
Department of Haematology, Christie Hospital, Manchester.
Citation:
Acute lymphoblastic leukaemia following Hodgkin's disease is associated with a good prognosis. 1994, 86 (4):867-9 Br. J. Haematol.
Journal:
British Journal of Haematology
Issue Date:
Apr-1994
URI:
http://hdl.handle.net/10541/97013
PubMed ID:
7918085
Type:
Article
Language:
en
ISSN:
0007-1048
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorNarayanan, M Nen
dc.contributor.authorMorgenstern, Godfrey Ren
dc.contributor.authorChang, Jamesen
dc.contributor.authorHarrison, Christine Jen
dc.contributor.authorRanson, Malcolm Ren
dc.contributor.authorScarffe, J Howarden
dc.date.accessioned2010-04-21T10:46:45Z-
dc.date.available2010-04-21T10:46:45Z-
dc.date.issued1994-04-
dc.identifier.citationAcute lymphoblastic leukaemia following Hodgkin's disease is associated with a good prognosis. 1994, 86 (4):867-9 Br. J. Haematol.en
dc.identifier.issn0007-1048-
dc.identifier.pmid7918085-
dc.identifier.urihttp://hdl.handle.net/10541/97013-
dc.description.abstractAcute leukaemia, both myeloid and lymphoblastic, in patients treated for Hodgkin's disease (HD) is thought to have a poor prognosis. We report four adults who developed secondary acute lymphoblastic leukaemia (ALL) following chemoradiotherapy for HD. The chromosomal translocation t(4;11) (q21;q23) was found in two patients who received a chemotherapeutic regimen containing the DNA topoisomerase II inhibitor etoposide. Three of the four patients are alive and in unmaintained first remission at 3, 5 and 9 years from diagnosis of ALL, two following autologous bone marrow transplantation. These results suggest that ALL following HD may have a good prognosis when treated aggressively.en
dc.language.isoenen
dc.subjectSecond Primary Canceren
dc.subjectPrecursor Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subject.meshAdult-
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols-
dc.subject.meshChromosomes, Human, Pair 11-
dc.subject.meshChromosomes, Human, Pair 4-
dc.subject.meshFemale-
dc.subject.meshFollow-Up Studies-
dc.subject.meshHodgkin Disease-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshNeoplasms, Second Primary-
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma-
dc.subject.meshPrognosis-
dc.subject.meshTranslocation, Genetic-
dc.titleAcute lymphoblastic leukaemia following Hodgkin's disease is associated with a good prognosis.en
dc.typeArticleen
dc.contributor.departmentDepartment of Haematology, Christie Hospital, Manchester.en
dc.identifier.journalBritish Journal of Haematologyen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.