Second primary neoplasms in a population-based series of patients diagnosed with renal tumours in childhood.
Affiliation
Department of Epidemiology and Social Oncology, Christie Hospital NHS Trust, Manchester, England.Issue Date
1994
Metadata
Show full item recordAbstract
Eight second malignant tumours developed in a population-based series of 218 patients diagnosed with renal tumours in childhood: renal cell carcinoma of the contralateral kidney, hepatocellular carcinoma, Hodgkin's disease, and 4 basal cell and 1 squamous cell carcinomas of skin. Excess risk of developing a second malignancy (excluding skin carcinomas but including a registrable spinal neurofibroma) was 14.7 (95% CI 4.0-37.7, P = 0.0003) for Wilms' tumour patients. Cumulative incidence of second malignant neoplasms (excluding skin carcinoma) was zero at 10 years, 5.0% at 20 years, and 10.2% at 30 years. The most common second neoplasms seen were benign osseous/chondromatous tumours and 4 of the 7 Wilms' tumour patients with malignant tumours had previous or synchronous tumours of this kind. Development of bony exostoses may be a marker for those patients at particularly high risk of subsequent malignancy.Citation
Second primary neoplasms in a population-based series of patients diagnosed with renal tumours in childhood. 1994, 22 (5):318-24 Med. Pediatr. Oncol.Journal
Medical and Pediatric OncologyDOI
10.1002/mpo.2950220504PubMed ID
8127255Type
ArticleLanguage
enISSN
0098-1532ae974a485f413a2113503eed53cd6c53
10.1002/mpo.2950220504
Scopus Count
Collections
Related articles
- Simultaneous Wilms' tumours in monozygotic twins. Case report and review of the literature.
- Authors: Svane S
- Issue date: 1997 Jun
- Second primary neoplasms in survivors of Wilms' tumour--a population-based cohort study from the British Childhood Cancer Survivor Study.
- Authors: Taylor AJ, Winter DL, Pritchard-Jones K, Stiller CA, Frobisher C, Lancashire ER, Reulen RC, Hawkins MM, British Childhood Cancer Survivor Study
- Issue date: 2008 May 1
- Diagnostic utility of Wilms' tumour-1 protein (WT-1) immunostaining in paediatric renal tumours.
- Authors: Goyal S, Mishra K, Sarkar U, Sharma S, Kumari A
- Issue date: 2016 May
- Second malignant neoplasms following treatment for Wilm's tumor: a report from the National Wilms' Tumor Study Group.
- Authors: Breslow NE, Takashima JR, Whitton JA, Moksness J, D'Angio GJ, Green DM
- Issue date: 1995 Aug
- Familial papillary renal cell tumors and subsequent cancers: a nationwide epidemiological study from Sweden.
- Authors: Czene K, Hemminki K
- Issue date: 2003 Apr