Second primary neoplasms in a population-based series of patients diagnosed with renal tumours in childhood.

2.50
Hdl Handle:
http://hdl.handle.net/10541/96985
Title:
Second primary neoplasms in a population-based series of patients diagnosed with renal tumours in childhood.
Authors:
Hartley, Ann L; Birch, Jillian M; Blair, Val; Jones, P M; Gattamaneni, Rao; Kelsey, Anna M
Abstract:
Eight second malignant tumours developed in a population-based series of 218 patients diagnosed with renal tumours in childhood: renal cell carcinoma of the contralateral kidney, hepatocellular carcinoma, Hodgkin's disease, and 4 basal cell and 1 squamous cell carcinomas of skin. Excess risk of developing a second malignancy (excluding skin carcinomas but including a registrable spinal neurofibroma) was 14.7 (95% CI 4.0-37.7, P = 0.0003) for Wilms' tumour patients. Cumulative incidence of second malignant neoplasms (excluding skin carcinoma) was zero at 10 years, 5.0% at 20 years, and 10.2% at 30 years. The most common second neoplasms seen were benign osseous/chondromatous tumours and 4 of the 7 Wilms' tumour patients with malignant tumours had previous or synchronous tumours of this kind. Development of bony exostoses may be a marker for those patients at particularly high risk of subsequent malignancy.
Affiliation:
Department of Epidemiology and Social Oncology, Christie Hospital NHS Trust, Manchester, England.
Citation:
Second primary neoplasms in a population-based series of patients diagnosed with renal tumours in childhood. 1994, 22 (5):318-24 Med. Pediatr. Oncol.
Journal:
Medical and Pediatric Oncology
Issue Date:
1994
URI:
http://hdl.handle.net/10541/96985
DOI:
10.1002/mpo.2950220504
PubMed ID:
8127255
Type:
Article
Language:
en
ISSN:
0098-1532
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorHartley, Ann Len
dc.contributor.authorBirch, Jillian Men
dc.contributor.authorBlair, Valen
dc.contributor.authorJones, P Men
dc.contributor.authorGattamaneni, Raoen
dc.contributor.authorKelsey, Anna Men
dc.date.accessioned2010-04-21T10:27:59Z-
dc.date.available2010-04-21T10:27:59Z-
dc.date.issued1994-
dc.identifier.citationSecond primary neoplasms in a population-based series of patients diagnosed with renal tumours in childhood. 1994, 22 (5):318-24 Med. Pediatr. Oncol.en
dc.identifier.issn0098-1532-
dc.identifier.pmid8127255-
dc.identifier.doi10.1002/mpo.2950220504-
dc.identifier.urihttp://hdl.handle.net/10541/96985-
dc.description.abstractEight second malignant tumours developed in a population-based series of 218 patients diagnosed with renal tumours in childhood: renal cell carcinoma of the contralateral kidney, hepatocellular carcinoma, Hodgkin's disease, and 4 basal cell and 1 squamous cell carcinomas of skin. Excess risk of developing a second malignancy (excluding skin carcinomas but including a registrable spinal neurofibroma) was 14.7 (95% CI 4.0-37.7, P = 0.0003) for Wilms' tumour patients. Cumulative incidence of second malignant neoplasms (excluding skin carcinoma) was zero at 10 years, 5.0% at 20 years, and 10.2% at 30 years. The most common second neoplasms seen were benign osseous/chondromatous tumours and 4 of the 7 Wilms' tumour patients with malignant tumours had previous or synchronous tumours of this kind. Development of bony exostoses may be a marker for those patients at particularly high risk of subsequent malignancy.en
dc.language.isoenen
dc.subjectKidney Canceren
dc.subjectSecond Primary Canceren
dc.subjectWilms Tumouren
dc.subject.meshAdolescent-
dc.subject.meshCarcinoma-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshFemale-
dc.subject.meshHodgkin Disease-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshKidney Neoplasms-
dc.subject.meshMale-
dc.subject.meshNeoplasms, Second Primary-
dc.subject.meshRisk-
dc.subject.meshWilms Tumor-
dc.titleSecond primary neoplasms in a population-based series of patients diagnosed with renal tumours in childhood.en
dc.typeArticleen
dc.contributor.departmentDepartment of Epidemiology and Social Oncology, Christie Hospital NHS Trust, Manchester, England.en
dc.identifier.journalMedical and Pediatric Oncologyen

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