The effects of low-level direct current therapy on a preclinical mammary carcinoma: tumour regression and systemic biochemical sequelae.

2.50
Hdl Handle:
http://hdl.handle.net/10541/96975
Title:
The effects of low-level direct current therapy on a preclinical mammary carcinoma: tumour regression and systemic biochemical sequelae.
Authors:
Griffin, D T; Dodd, Nicholas J F; Moore, James V; Pullan, B R; Taylor, T V
Abstract:
Low-level direct electric current has been shown to be capable of destroying tumour tissue. Using an early-passage subcutaneous murine mammary carcinoma, the relationships between the volume of tumour destruction, charge and polarity have been examined. The results revealed a direct correlation between charge passed and absolute volume regression when the intratumoral electrode was made either an anode or a cathode. Tumour destruction for a given charge was significantly greater following anodic than cathodic treatment. A direct correlation was also observed between the percentage volume of prompt treatment-induced regression and the in situ end point of tumour growth delay. During the course of these experiments, a highly reproducible toxic effect was discovered, which has not been previously reported for this modality. An anodic charge greater than 10.6 coulombs or a cathodic charge greater than 21.6 coulombs resulted in 100% mortality at 24-72 h, while lower charges had no influence on mortality. Quantitative assays of a number of blood parameters showed that mortality was associated with serum electrolyte imbalances and appeared to be the result of the metabolic load of tumour breakdown products. These effects are similar to the tumour lysis or surgical crush syndromes and should not constitute a significant problem in clinical practice, where the tumour mass to total body mass ratio will normally be much smaller.
Affiliation:
Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK.
Citation:
The effects of low-level direct current therapy on a preclinical mammary carcinoma: tumour regression and systemic biochemical sequelae. 1994, 69 (5):875-8 Br. J. Cancer
Journal:
British Journal of Cancer
Issue Date:
May-1994
URI:
http://hdl.handle.net/10541/96975
PubMed ID:
8180017
Type:
Article
Language:
en
ISSN:
0007-0920
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorGriffin, D Ten
dc.contributor.authorDodd, Nicholas J Fen
dc.contributor.authorMoore, James Ven
dc.contributor.authorPullan, B Ren
dc.contributor.authorTaylor, T Ven
dc.date.accessioned2010-04-21T09:17:27Z-
dc.date.available2010-04-21T09:17:27Z-
dc.date.issued1994-05-
dc.identifier.citationThe effects of low-level direct current therapy on a preclinical mammary carcinoma: tumour regression and systemic biochemical sequelae. 1994, 69 (5):875-8 Br. J. Canceren
dc.identifier.issn0007-0920-
dc.identifier.pmid8180017-
dc.identifier.urihttp://hdl.handle.net/10541/96975-
dc.description.abstractLow-level direct electric current has been shown to be capable of destroying tumour tissue. Using an early-passage subcutaneous murine mammary carcinoma, the relationships between the volume of tumour destruction, charge and polarity have been examined. The results revealed a direct correlation between charge passed and absolute volume regression when the intratumoral electrode was made either an anode or a cathode. Tumour destruction for a given charge was significantly greater following anodic than cathodic treatment. A direct correlation was also observed between the percentage volume of prompt treatment-induced regression and the in situ end point of tumour growth delay. During the course of these experiments, a highly reproducible toxic effect was discovered, which has not been previously reported for this modality. An anodic charge greater than 10.6 coulombs or a cathodic charge greater than 21.6 coulombs resulted in 100% mortality at 24-72 h, while lower charges had no influence on mortality. Quantitative assays of a number of blood parameters showed that mortality was associated with serum electrolyte imbalances and appeared to be the result of the metabolic load of tumour breakdown products. These effects are similar to the tumour lysis or surgical crush syndromes and should not constitute a significant problem in clinical practice, where the tumour mass to total body mass ratio will normally be much smaller.en
dc.language.isoenen
dc.subjectMammary Canceren
dc.subjectAnimal Mammary Canceren
dc.subject.meshAnimals-
dc.subject.meshElectric Stimulation Therapy-
dc.subject.meshMale-
dc.subject.meshMammary Neoplasms, Animal-
dc.subject.meshMice-
dc.subject.meshRandom Allocation-
dc.titleThe effects of low-level direct current therapy on a preclinical mammary carcinoma: tumour regression and systemic biochemical sequelae.en
dc.typeArticleen
dc.contributor.departmentPaterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren
All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.