Rare variant (Glu to Lys) in the leucine zipper region of CHOP (GADD153).

2.50
Hdl Handle:
http://hdl.handle.net/10541/96302
Title:
Rare variant (Glu to Lys) in the leucine zipper region of CHOP (GADD153).
Authors:
Heighway, Jim; White, Gavin R M; Hartley, Ann L; Birch, Jillian M; Santibanez-Koref, Mauro F
Abstract:
CHOP (GADD153) has been shown to be a dominant negative inhibitor of specific transcription factors. Direct sequencing of the gene, amplified from the DNA of a Li-Fraumeni family index case (liposarcoma, breast cancer) revealed a constitutional variant within the coding region. This alteration, though not responsible for the Li-Fraumeni phenotype, resulted in a glutamic acid to lysine switch within the leucine zipper domain, at a residue conserved between CHOP and its potential target molecules and between the human and hamster sequences. The variant created a Taq I restriction fragment length polymorphism (RFLP) facilitating screening. Analysis of 159 breast tumour DNA samples detected two encoding variant alleles (tumour and constitutional DNA).
Affiliation:
CRC Dept of Cancer Genetics, Paterson Institute for Cancer Research, Christie CRC Research Centre, Manchester, UK.
Citation:
Rare variant (Glu to Lys) in the leucine zipper region of CHOP (GADD153). 1994, 9 (9):2737-8 Oncogene
Journal:
Oncogene
Issue Date:
Sep-1994
URI:
http://hdl.handle.net/10541/96302
PubMed ID:
8058339
Type:
Article
Language:
en
ISSN:
0950-9232
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHeighway, Jimen
dc.contributor.authorWhite, Gavin R Men
dc.contributor.authorHartley, Ann Len
dc.contributor.authorBirch, Jillian Men
dc.contributor.authorSantibanez-Koref, Mauro Fen
dc.date.accessioned2010-04-12T12:47:34Z-
dc.date.available2010-04-12T12:47:34Z-
dc.date.issued1994-09-
dc.identifier.citationRare variant (Glu to Lys) in the leucine zipper region of CHOP (GADD153). 1994, 9 (9):2737-8 Oncogeneen
dc.identifier.issn0950-9232-
dc.identifier.pmid8058339-
dc.identifier.urihttp://hdl.handle.net/10541/96302-
dc.description.abstractCHOP (GADD153) has been shown to be a dominant negative inhibitor of specific transcription factors. Direct sequencing of the gene, amplified from the DNA of a Li-Fraumeni family index case (liposarcoma, breast cancer) revealed a constitutional variant within the coding region. This alteration, though not responsible for the Li-Fraumeni phenotype, resulted in a glutamic acid to lysine switch within the leucine zipper domain, at a residue conserved between CHOP and its potential target molecules and between the human and hamster sequences. The variant created a Taq I restriction fragment length polymorphism (RFLP) facilitating screening. Analysis of 159 breast tumour DNA samples detected two encoding variant alleles (tumour and constitutional DNA).en
dc.language.isoenen
dc.subjectBreast Cancer-
dc.subject.meshAdult-
dc.subject.meshBase Sequence-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCCAAT-Enhancer-Binding Proteins-
dc.subject.meshDNA-Binding Proteins-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLeucine Zippers-
dc.subject.meshMolecular Sequence Data-
dc.subject.meshNeoplasms-
dc.subject.meshNuclear Proteins-
dc.subject.meshTranscription Factor CHOP-
dc.subject.meshTranscription Factors-
dc.titleRare variant (Glu to Lys) in the leucine zipper region of CHOP (GADD153).en
dc.typeArticleen
dc.contributor.departmentCRC Dept of Cancer Genetics, Paterson Institute for Cancer Research, Christie CRC Research Centre, Manchester, UK.en
dc.identifier.journalOncogeneen

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