The use of loss of constitutional heterozygosity data to ascertain the location of predisposing genes in cancer families.

2.50
Hdl Handle:
http://hdl.handle.net/10541/96299
Title:
The use of loss of constitutional heterozygosity data to ascertain the location of predisposing genes in cancer families.
Authors:
Teare, M Dawn; Rohde, K; Santibanez-Koref, Mauro F
Abstract:
A method is described to investigate the inheritance of disease predisposition in cancer families. It is an extension of classic genetic linkage analysis, which enables information on loss of constitutional heterozygosity (LOCH) to be incorporated into the model. This adapted model treats LOCH data as additional observations on the disease phenotype. One of the major benefits of this approach is that isolated parent-offspring pairs are now potentially informative for linkage analysis. Examples are presented.
Affiliation:
Cancer Research Campaign, Paediatric and Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, UK.
Citation:
The use of loss of constitutional heterozygosity data to ascertain the location of predisposing genes in cancer families. 1994, 31 (6):448-52 J. Med. Genet.
Journal:
Journal of Medical Genetics
Issue Date:
Jun-1994
URI:
http://hdl.handle.net/10541/96299
DOI:
10.1136/jmg.31.6.448
PubMed ID:
8071970
Type:
Article
Language:
en
ISSN:
0022-2593
Appears in Collections:
All Christie Publications ; All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorTeare, M Dawnen
dc.contributor.authorRohde, Ken
dc.contributor.authorSantibanez-Koref, Mauro Fen
dc.date.accessioned2010-04-12T12:37:53Z-
dc.date.available2010-04-12T12:37:53Z-
dc.date.issued1994-06-
dc.identifier.citationThe use of loss of constitutional heterozygosity data to ascertain the location of predisposing genes in cancer families. 1994, 31 (6):448-52 J. Med. Genet.en
dc.identifier.issn0022-2593-
dc.identifier.pmid8071970-
dc.identifier.doi10.1136/jmg.31.6.448-
dc.identifier.urihttp://hdl.handle.net/10541/96299-
dc.description.abstractA method is described to investigate the inheritance of disease predisposition in cancer families. It is an extension of classic genetic linkage analysis, which enables information on loss of constitutional heterozygosity (LOCH) to be incorporated into the model. This adapted model treats LOCH data as additional observations on the disease phenotype. One of the major benefits of this approach is that isolated parent-offspring pairs are now potentially informative for linkage analysis. Examples are presented.en
dc.language.isoenen
dc.subjectBreast Cancer-
dc.subject.meshAlleles-
dc.subject.meshBreast Neoplasms-
dc.subject.meshFemale-
dc.subject.meshGene Deletion-
dc.subject.meshGenes, Tumor Suppressor-
dc.subject.meshGenes, p53-
dc.subject.meshHeterozygote-
dc.subject.meshHumans-
dc.subject.meshLi-Fraumeni Syndrome-
dc.subject.meshLinkage (Genetics)-
dc.subject.meshMale-
dc.subject.meshModels, Genetic-
dc.subject.meshNeoplastic Syndromes, Hereditary-
dc.titleThe use of loss of constitutional heterozygosity data to ascertain the location of predisposing genes in cancer families.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign, Paediatric and Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalJournal of Medical Geneticsen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.