Drug-resistance associated alterations of cell surface antigen expression in a human anthracycline-resistant ovarian carcinoma cell line.

2.50
Hdl Handle:
http://hdl.handle.net/10541/96172
Title:
Drug-resistance associated alterations of cell surface antigen expression in a human anthracycline-resistant ovarian carcinoma cell line.
Authors:
Sedlák, J; McGown, Alan T; Hrubisko, M; Hunáková, L; Chorváth, B
Abstract:
The anthracycline uptake and cell surface expression of plasma membrane antigens (HLA class I, c-erbB-2, protectin-CD59, integrin beta 1-chain-CD29, etc.) were compared on a parental anthracycline sensitive and an anthracycline-resistant subline of the human ovarian carcinoma cell line A2780. The anthracycline-resistant (A2780/ADR) subline incubated for 30 min in the presence of daunomycin displayed two subpopulations with different anthracycline cell content as determined by flow cytometry. The subpopulation with lower daunomycin cell content was absent in the parental anthracycline sensitive cell line. The most predominant antigenic changes on the resistant subline as compared with the sensitive one were as follow: Loss of HLA class I and a twofold increase in the expression of CD59 antigen and a slight decrease of integrin beta 1-chain on the cell surface of the resistant subline.
Affiliation:
Cancer Research Institute, Slovak Academy of Sciences, Bratislava.
Citation:
Drug-resistance associated alterations of cell surface antigen expression in a human anthracycline-resistant ovarian carcinoma cell line. 1994, 41 (5):259-62 Neoplasma
Journal:
Neoplasma
Issue Date:
1994
URI:
http://hdl.handle.net/10541/96172
PubMed ID:
7854495
Type:
Article
Language:
en
ISSN:
0028-2685
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorSedlák, Jen
dc.contributor.authorMcGown, Alan Ten
dc.contributor.authorHrubisko, Men
dc.contributor.authorHunáková, Len
dc.contributor.authorChorváth, Ben
dc.date.accessioned2010-04-09T13:44:54Z-
dc.date.available2010-04-09T13:44:54Z-
dc.date.issued1994-
dc.identifier.citationDrug-resistance associated alterations of cell surface antigen expression in a human anthracycline-resistant ovarian carcinoma cell line. 1994, 41 (5):259-62 Neoplasmaen
dc.identifier.issn0028-2685-
dc.identifier.pmid7854495-
dc.identifier.urihttp://hdl.handle.net/10541/96172-
dc.description.abstractThe anthracycline uptake and cell surface expression of plasma membrane antigens (HLA class I, c-erbB-2, protectin-CD59, integrin beta 1-chain-CD29, etc.) were compared on a parental anthracycline sensitive and an anthracycline-resistant subline of the human ovarian carcinoma cell line A2780. The anthracycline-resistant (A2780/ADR) subline incubated for 30 min in the presence of daunomycin displayed two subpopulations with different anthracycline cell content as determined by flow cytometry. The subpopulation with lower daunomycin cell content was absent in the parental anthracycline sensitive cell line. The most predominant antigenic changes on the resistant subline as compared with the sensitive one were as follow: Loss of HLA class I and a twofold increase in the expression of CD59 antigen and a slight decrease of integrin beta 1-chain on the cell surface of the resistant subline.en
dc.language.isoenen
dc.subjectCancer Antigensen
dc.subjectCancer DNAen
dc.subjectOvarian Canceren
dc.subjectCultured Tumour Cellsen
dc.subject.meshAntibiotics, Antineoplastic-
dc.subject.meshAntigens, Neoplasm-
dc.subject.meshAntigens, Surface-
dc.subject.meshCell Cycle-
dc.subject.meshDNA, Neoplasm-
dc.subject.meshDaunorubicin-
dc.subject.meshDrug Resistance-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshOvarian Neoplasms-
dc.subject.meshTumor Cells, Cultured-
dc.titleDrug-resistance associated alterations of cell surface antigen expression in a human anthracycline-resistant ovarian carcinoma cell line.en
dc.typeArticleen
dc.contributor.departmentCancer Research Institute, Slovak Academy of Sciences, Bratislava.en
dc.identifier.journalNeoplasmaen

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