Granulocyte colony stimulating factor: from laboratory bench to clinical use.

2.50
Hdl Handle:
http://hdl.handle.net/10541/96141
Title:
Granulocyte colony stimulating factor: from laboratory bench to clinical use.
Authors:
Dexter, T Michael
Abstract:
A great deal has been learned about haematopoiesis since the discovery, purification and cloning of haemopoietic growth factors. The function of these growth factors is to promote survival and enhance mitosis (at higher concentrations), and influence differentiation and development of stem cells and progenitor cells. The type of mature cells produced reflects the combinations of growth factors to which the stem cells are exposed. Growth factors may also control the functional activity of mature cells. Treatment with granulocyte colony stimulating factor (G-CSF) produces neutrophils that are at least equivalent to those produced during normal haematopoiesis and does not appear to deplete the haematopoietic stem or progenitor cell populations.
Affiliation:
Department of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, U.K.
Citation:
Granulocyte colony stimulating factor: from laboratory bench to clinical use. 1994, 30A Suppl 3:S15-9 Eur. J. Cancer
Journal:
European Journal of Cancer
Issue Date:
1994
URI:
http://hdl.handle.net/10541/96141
PubMed ID:
7535066
Type:
Article
Language:
en
ISSN:
0959-8049
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorDexter, T Michaelen
dc.date.accessioned2010-04-09T11:31:44Z-
dc.date.available2010-04-09T11:31:44Z-
dc.date.issued1994-
dc.identifier.citationGranulocyte colony stimulating factor: from laboratory bench to clinical use. 1994, 30A Suppl 3:S15-9 Eur. J. Canceren
dc.identifier.issn0959-8049-
dc.identifier.pmid7535066-
dc.identifier.urihttp://hdl.handle.net/10541/96141-
dc.description.abstractA great deal has been learned about haematopoiesis since the discovery, purification and cloning of haemopoietic growth factors. The function of these growth factors is to promote survival and enhance mitosis (at higher concentrations), and influence differentiation and development of stem cells and progenitor cells. The type of mature cells produced reflects the combinations of growth factors to which the stem cells are exposed. Growth factors may also control the functional activity of mature cells. Treatment with granulocyte colony stimulating factor (G-CSF) produces neutrophils that are at least equivalent to those produced during normal haematopoiesis and does not appear to deplete the haematopoietic stem or progenitor cell populations.en
dc.language.isoenen
dc.subjectHaematopoietic Cell Growth Factorsen
dc.subject.meshAnimals-
dc.subject.meshCell Division-
dc.subject.meshErythroid Precursor Cells-
dc.subject.meshGranulocyte Colony-Stimulating Factor-
dc.subject.meshHematopoietic Cell Growth Factors-
dc.subject.meshHumans-
dc.subject.meshNeutrophils-
dc.titleGranulocyte colony stimulating factor: from laboratory bench to clinical use.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Haematology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, U.K.en
dc.identifier.journalEuropean Journal of Canceren
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