2.50
Hdl Handle:
http://hdl.handle.net/10541/96133
Title:
In vivo laser light distribution in human prostatic carcinoma.
Authors:
Whitehurst, Colin; Pantelides, M L; Moore, James V; Brooman, P J; Blacklock, N J
Abstract:
The extent of laser light diffusion within prostatic tumor is of major importance in the treatment of localized prostatic cancer with photodynamic therapy (PDT). The penetration of 633 nm. wavelength red light was studied in eleven patients with suspected prostatic cancer using a novel method suitable for in situ measurements. Light delivery and detector fiber, placed interstitially within the gland, determined light attenuation at different interfiber separations. Of 11 patients, 10 had bilateral and 1 had single lobe studies. The mean +/- the standard error of the mean attenuation coefficients (sigma eff) for benign and malignant prostate tissue were 0.35 +/- 0.02 mm-1 and 0.36 +/- 0.02 mm-1, respectively, indicating similar optical densities (p = .58). Patients with bilateral lobe involvement showed little intraglandular variation in sigma eff (p = 0.23). However, there was interpatient variation (sigma eff = 0.28 to 0.48 mm-1) reflecting biological differences which, though therapeutically important, were not statistically significant (p = 0.057). This study showed that treatment requires individualization and predicted that 4 cylindrical diffusers are expected to destroy 25 ml. of prostatic tumor with PDT.
Affiliation:
Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, United Kingdom.
Citation:
In vivo laser light distribution in human prostatic carcinoma. 1994, 151 (5):1411-5 J. Urol.
Journal:
The Journal of Urology
Issue Date:
May-1994
URI:
http://hdl.handle.net/10541/96133
PubMed ID:
8158797
Type:
Article
Language:
en
ISSN:
0022-5347
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorWhitehurst, Colinen
dc.contributor.authorPantelides, M Len
dc.contributor.authorMoore, James Ven
dc.contributor.authorBrooman, P Jen
dc.contributor.authorBlacklock, N Jen
dc.date.accessioned2010-04-09T10:53:00Z-
dc.date.available2010-04-09T10:53:00Z-
dc.date.issued1994-05-
dc.identifier.citationIn vivo laser light distribution in human prostatic carcinoma. 1994, 151 (5):1411-5 J. Urol.en
dc.identifier.issn0022-5347-
dc.identifier.pmid8158797-
dc.identifier.urihttp://hdl.handle.net/10541/96133-
dc.description.abstractThe extent of laser light diffusion within prostatic tumor is of major importance in the treatment of localized prostatic cancer with photodynamic therapy (PDT). The penetration of 633 nm. wavelength red light was studied in eleven patients with suspected prostatic cancer using a novel method suitable for in situ measurements. Light delivery and detector fiber, placed interstitially within the gland, determined light attenuation at different interfiber separations. Of 11 patients, 10 had bilateral and 1 had single lobe studies. The mean +/- the standard error of the mean attenuation coefficients (sigma eff) for benign and malignant prostate tissue were 0.35 +/- 0.02 mm-1 and 0.36 +/- 0.02 mm-1, respectively, indicating similar optical densities (p = .58). Patients with bilateral lobe involvement showed little intraglandular variation in sigma eff (p = 0.23). However, there was interpatient variation (sigma eff = 0.28 to 0.48 mm-1) reflecting biological differences which, though therapeutically important, were not statistically significant (p = 0.057). This study showed that treatment requires individualization and predicted that 4 cylindrical diffusers are expected to destroy 25 ml. of prostatic tumor with PDT.en
dc.language.isoenen
dc.subjectProstatic Canceren
dc.subject.meshHumans-
dc.subject.meshLaser Therapy-
dc.subject.meshMale-
dc.subject.meshPhotochemotherapy-
dc.subject.meshProstatic Neoplasms-
dc.titleIn vivo laser light distribution in human prostatic carcinoma.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital, Manchester, United Kingdom.en
dc.identifier.journalThe Journal of Urologyen

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