2.50
Hdl Handle:
http://hdl.handle.net/10541/96127
Title:
Heparan sulphates as membrane receptors for the fibroblast growth factors.
Authors:
Gallagher, John T
Abstract:
The complex polymeric structure of heparan sulphate contains intra-chain sequences of sulphated sugar residues that define active sites for the binding and activation of growth factors. The molecular mechanisms of recognition and activation are slowly being revealed at least in the case of the interaction of heparan sulphate with basic fibroblast growth factor. Current data indicate that relatively long but specific binding sequences in heparan sulphate may induce a conformational change in basic fibroblast growth factor exposing a site on the protein that is recognised by signal transducing receptors. Heparan sulphate may also subserve functions of dimerisation of basic fibroblast growth factor and facilitation of receptor transfer by a secondary interaction with the receptor itself. Various models for heparan sulphate mediated induction of mitogenesis by basic fibroblast growth factor have been proposed and there are suggestions that the core protein of plasma membrane heparan sulphate-proteoglycans may participate in the cell signalling process. The vital importance of heparan sulphate in controlling growth factor activities has opened up a new chapter in proteoglycan research and has brought proteoglycans into the mainstream of cell biology. Further investigation of their mode of action is likely to reveal new information on the control of cell growth and development in both embryonic and adult tissues and may suggest novel methods of controlling diseases such as cancer, atherosclerosis or fibrosis that are driven by abnormal expression of growth factors or their receptors.
Affiliation:
Med. Oncology Department, University of Manchester, Christie Hospital, United Kingdom.
Citation:
Heparan sulphates as membrane receptors for the fibroblast growth factors. 1994, 32 (4):239-47 Eur J Clin Chem Clin Biochem
Journal:
European Journal of Clinical Chemistry and Clinical Biochemistry
Issue Date:
Apr-1994
URI:
http://hdl.handle.net/10541/96127
PubMed ID:
8038264
Type:
Article
Language:
en
ISSN:
0939-4974
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorGallagher, John Ten
dc.date.accessioned2010-04-09T11:26:00Z-
dc.date.available2010-04-09T11:26:00Z-
dc.date.issued1994-04-
dc.identifier.citationHeparan sulphates as membrane receptors for the fibroblast growth factors. 1994, 32 (4):239-47 Eur J Clin Chem Clin Biochemen
dc.identifier.issn0939-4974-
dc.identifier.pmid8038264-
dc.identifier.urihttp://hdl.handle.net/10541/96127-
dc.description.abstractThe complex polymeric structure of heparan sulphate contains intra-chain sequences of sulphated sugar residues that define active sites for the binding and activation of growth factors. The molecular mechanisms of recognition and activation are slowly being revealed at least in the case of the interaction of heparan sulphate with basic fibroblast growth factor. Current data indicate that relatively long but specific binding sequences in heparan sulphate may induce a conformational change in basic fibroblast growth factor exposing a site on the protein that is recognised by signal transducing receptors. Heparan sulphate may also subserve functions of dimerisation of basic fibroblast growth factor and facilitation of receptor transfer by a secondary interaction with the receptor itself. Various models for heparan sulphate mediated induction of mitogenesis by basic fibroblast growth factor have been proposed and there are suggestions that the core protein of plasma membrane heparan sulphate-proteoglycans may participate in the cell signalling process. The vital importance of heparan sulphate in controlling growth factor activities has opened up a new chapter in proteoglycan research and has brought proteoglycans into the mainstream of cell biology. Further investigation of their mode of action is likely to reveal new information on the control of cell growth and development in both embryonic and adult tissues and may suggest novel methods of controlling diseases such as cancer, atherosclerosis or fibrosis that are driven by abnormal expression of growth factors or their receptors.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshCarbohydrate Sequence-
dc.subject.meshHeparitin Sulfate-
dc.subject.meshMolecular Sequence Data-
dc.subject.meshReceptors, Fibroblast Growth Factor-
dc.titleHeparan sulphates as membrane receptors for the fibroblast growth factors.en
dc.typeArticleen
dc.contributor.departmentMed. Oncology Department, University of Manchester, Christie Hospital, United Kingdom.en
dc.identifier.journalEuropean Journal of Clinical Chemistry and Clinical Biochemistryen
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