Immunization of cottontop tamarins and rabbits with a candidate vaccine against the Epstein-Barr virus based on the major viral envelope glycoprotein gp340 and alum.

2.50
Hdl Handle:
http://hdl.handle.net/10541/96126
Title:
Immunization of cottontop tamarins and rabbits with a candidate vaccine against the Epstein-Barr virus based on the major viral envelope glycoprotein gp340 and alum.
Authors:
Finerty, S; Mackett, Mike; Arrand, John R; Watkins, P E; Tarlton, J; Morgan, A J
Abstract:
The Epstein-Barr virus (EBV) is associated with a range of life-threatening diseases in humans. Development of an effective vaccine has therefore been an important objective. One problem in the development of a subunit vaccine for human administration is the selection of a satisfactory adjuvant since the only one currently licensed for human use is alum, although this is not considered to be very effective. The present study demonstrated that a subunit vaccine composed of the EBV envelope glycoprotein gp340 with alum as the adjuvant did elicit protective immunity against EBV-induced lymphoma in three out of five cottontop tamarins. Furthermore, rabbits immunized with gp340/alum developed the same range of antibody responses as rabbits immunized with gp340/SAF-1, an experimental adjuvant claimed to be more effective than alum. Therefore, these results indicate that alum should be evaluated as an adjuvant as part of a human trial of a gp340-based subunit vaccine.
Affiliation:
Department of Pathology, School of Medical Sciences, University of Bristol, UK.
Citation:
Immunization of cottontop tamarins and rabbits with a candidate vaccine against the Epstein-Barr virus based on the major viral envelope glycoprotein gp340 and alum. 1994, 12 (13):1180-4 Vaccine
Journal:
Vaccine
Issue Date:
Oct-1994
URI:
http://hdl.handle.net/10541/96126
DOI:
10.1016/0264-410X(94)90240-2
PubMed ID:
7839721
Type:
Article
Language:
en
ISSN:
0264-410X
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorFinerty, Sen
dc.contributor.authorMackett, Mikeen
dc.contributor.authorArrand, John Ren
dc.contributor.authorWatkins, P Een
dc.contributor.authorTarlton, Jen
dc.contributor.authorMorgan, A Jen
dc.date.accessioned2010-04-09T11:22:57Z-
dc.date.available2010-04-09T11:22:57Z-
dc.date.issued1994-10-
dc.identifier.citationImmunization of cottontop tamarins and rabbits with a candidate vaccine against the Epstein-Barr virus based on the major viral envelope glycoprotein gp340 and alum. 1994, 12 (13):1180-4 Vaccineen
dc.identifier.issn0264-410X-
dc.identifier.pmid7839721-
dc.identifier.doi10.1016/0264-410X(94)90240-2-
dc.identifier.urihttp://hdl.handle.net/10541/96126-
dc.description.abstractThe Epstein-Barr virus (EBV) is associated with a range of life-threatening diseases in humans. Development of an effective vaccine has therefore been an important objective. One problem in the development of a subunit vaccine for human administration is the selection of a satisfactory adjuvant since the only one currently licensed for human use is alum, although this is not considered to be very effective. The present study demonstrated that a subunit vaccine composed of the EBV envelope glycoprotein gp340 with alum as the adjuvant did elicit protective immunity against EBV-induced lymphoma in three out of five cottontop tamarins. Furthermore, rabbits immunized with gp340/alum developed the same range of antibody responses as rabbits immunized with gp340/SAF-1, an experimental adjuvant claimed to be more effective than alum. Therefore, these results indicate that alum should be evaluated as an adjuvant as part of a human trial of a gp340-based subunit vaccine.en
dc.language.isoenen
dc.subject.meshAdjuvants, Immunologic-
dc.subject.meshAlum Compounds-
dc.subject.meshAnimals-
dc.subject.meshAntibodies, Viral-
dc.subject.meshAntigens, Viral-
dc.subject.meshFemale-
dc.subject.meshHerpesviridae Infections-
dc.subject.meshHerpesvirus 4, Human-
dc.subject.meshHumans-
dc.subject.meshImmunization-
dc.subject.meshMale-
dc.subject.meshRabbits-
dc.subject.meshSaguinus-
dc.subject.meshTumor Virus Infections-
dc.subject.meshVaccines, Synthetic-
dc.subject.meshViral Matrix Proteins-
dc.subject.meshViral Vaccines-
dc.titleImmunization of cottontop tamarins and rabbits with a candidate vaccine against the Epstein-Barr virus based on the major viral envelope glycoprotein gp340 and alum.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, School of Medical Sciences, University of Bristol, UK.en
dc.identifier.journalVaccineen
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