2.50
Hdl Handle:
http://hdl.handle.net/10541/96104
Title:
Structure-activity studies on 2-aryl-4H-3,1-benzoxazin-4-ones.
Authors:
Hadfield, John A; Pavlidis, V H; McGown, Alan T; Whitworth, C; Perry, P J; Fox, Brian W
Abstract:
Eight benzoxazin-4-ones related in structure to NSC 341964 (1) have been tested for cytotoxicity in two different cell systems. Two of the benzoxazin-4-ones (3 and 10) showed good cytotoxicity (ID50 = 9.9 and 8.9 microM) in P388 cells. The nitrobenzoxazin-4-one (10) caused a significant alteration in cell cycle distribution when administered to P388 cells and was an inhibitor of porcine pancreatic elastase. Structure-activity relationships are discussed.
Affiliation:
CRC Department of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.
Citation:
Structure-activity studies on 2-aryl-4H-3,1-benzoxazin-4-ones. 1994, 5 (5):533-8 Anticancer Drugs
Journal:
Anti-Cancer Drugs
Issue Date:
Oct-1994
URI:
http://hdl.handle.net/10541/96104
PubMed ID:
7858285
Type:
Article
Language:
en
ISSN:
0959-4973
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHadfield, John Aen
dc.contributor.authorPavlidis, V Hen
dc.contributor.authorMcGown, Alan Ten
dc.contributor.authorWhitworth, Cen
dc.contributor.authorPerry, P Jen
dc.contributor.authorFox, Brian Wen
dc.date.accessioned2010-04-09T09:04:41Z-
dc.date.available2010-04-09T09:04:41Z-
dc.date.issued1994-10-
dc.identifier.citationStructure-activity studies on 2-aryl-4H-3,1-benzoxazin-4-ones. 1994, 5 (5):533-8 Anticancer Drugsen
dc.identifier.issn0959-4973-
dc.identifier.pmid7858285-
dc.identifier.urihttp://hdl.handle.net/10541/96104-
dc.description.abstractEight benzoxazin-4-ones related in structure to NSC 341964 (1) have been tested for cytotoxicity in two different cell systems. Two of the benzoxazin-4-ones (3 and 10) showed good cytotoxicity (ID50 = 9.9 and 8.9 microM) in P388 cells. The nitrobenzoxazin-4-one (10) caused a significant alteration in cell cycle distribution when administered to P388 cells and was an inhibitor of porcine pancreatic elastase. Structure-activity relationships are discussed.en
dc.language.isoenen
dc.subjectCancer DNAen
dc.subjectAntitumour Drug Screening Assaysen
dc.subjectLeukaemia P388en
dc.subjectCultured Tumour Cellsen
dc.subject.meshAnimals-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshDNA, Neoplasm-
dc.subject.meshDrug Screening Assays, Antitumor-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshKB Cells-
dc.subject.meshLeukemia P388-
dc.subject.meshMagnetic Resonance Spectroscopy-
dc.subject.meshMice-
dc.subject.meshMice, Inbred DBA-
dc.subject.meshModels, Molecular-
dc.subject.meshOxazines-
dc.subject.meshPancreatic Elastase-
dc.subject.meshStructure-Activity Relationship-
dc.subject.meshSwine-
dc.subject.meshTetrazolium Salts-
dc.subject.meshThiazoles-
dc.subject.meshTumor Cells, Cultured-
dc.titleStructure-activity studies on 2-aryl-4H-3,1-benzoxazin-4-ones.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.en
dc.identifier.journalAnti-Cancer Drugsen

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