The karyotype of Alligator mississippiensis, and chromosomal mapping of the ZFY/X homologue, Zfc.

2.50
Hdl Handle:
http://hdl.handle.net/10541/96103
Title:
The karyotype of Alligator mississippiensis, and chromosomal mapping of the ZFY/X homologue, Zfc.
Authors:
Valleley, E M; Harrison, Christine J; Cook, Yvonne; Ferguson, M W; Sharpe, P T
Abstract:
Comparative mapping studies of X-linked genes in mammals have provided insights into the evolution of the X chromosome. Many reptiles including the American alligator, Alligator mississippiensis, do not appear to possess heteromorphic sex chromosomes, and sex is determined by the incubation temperature of the egg during embryonic development. Mapping of homologues of mammalian X-linked genes in reptiles could lead to a greater understanding of the evolution of vertebrate sex chromosomes. One of the genes used in the mammalian mapping studies was ZFX, an X-linked copy of the human ZFY gene which was originally isolated as a candidate for the mammalian testis-determining factor (TDF). ZFX is X-linked in eutherians, but maps to two autosomal locations in marsupials and monotremes, close to other genes associated with the eutherian X. The alligator homologue of the ZFY/ZFX genes, Zfc, has been isolated and described previously. A detailed karyotype of A. mississippiensis is presented, together with chromosomal in situ hybridisation data localising the Zfc gene to chromosome 3. Further chromosomal mapping studies using eutherian X-linked genes may reveal conserved chromosomal regions in the alligator that have become part of the eutherian X chromosome during evolution.
Affiliation:
School of Biological Sciences, University of Manchester, UK.
Citation:
The karyotype of Alligator mississippiensis, and chromosomal mapping of the ZFY/X homologue, Zfc. 1994, 103 (7):502-7 Chromosoma
Journal:
Chromosoma
Issue Date:
Dec-1994
URI:
http://hdl.handle.net/10541/96103
DOI:
10.1007/BF00337388
PubMed ID:
7720416
Type:
Article
Language:
en
ISSN:
0009-5915
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorValleley, E Men
dc.contributor.authorHarrison, Christine Jen
dc.contributor.authorCook, Yvonneen
dc.contributor.authorFerguson, M Wen
dc.contributor.authorSharpe, P Ten
dc.date.accessioned2010-04-09T09:01:53Z-
dc.date.available2010-04-09T09:01:53Z-
dc.date.issued1994-12-
dc.identifier.citationThe karyotype of Alligator mississippiensis, and chromosomal mapping of the ZFY/X homologue, Zfc. 1994, 103 (7):502-7 Chromosomaen
dc.identifier.issn0009-5915-
dc.identifier.pmid7720416-
dc.identifier.doi10.1007/BF00337388-
dc.identifier.urihttp://hdl.handle.net/10541/96103-
dc.description.abstractComparative mapping studies of X-linked genes in mammals have provided insights into the evolution of the X chromosome. Many reptiles including the American alligator, Alligator mississippiensis, do not appear to possess heteromorphic sex chromosomes, and sex is determined by the incubation temperature of the egg during embryonic development. Mapping of homologues of mammalian X-linked genes in reptiles could lead to a greater understanding of the evolution of vertebrate sex chromosomes. One of the genes used in the mammalian mapping studies was ZFX, an X-linked copy of the human ZFY gene which was originally isolated as a candidate for the mammalian testis-determining factor (TDF). ZFX is X-linked in eutherians, but maps to two autosomal locations in marsupials and monotremes, close to other genes associated with the eutherian X. The alligator homologue of the ZFY/ZFX genes, Zfc, has been isolated and described previously. A detailed karyotype of A. mississippiensis is presented, together with chromosomal in situ hybridisation data localising the Zfc gene to chromosome 3. Further chromosomal mapping studies using eutherian X-linked genes may reveal conserved chromosomal regions in the alligator that have become part of the eutherian X chromosome during evolution.en
dc.language.isoenen
dc.subject.meshAlligators and Crocodiles-
dc.subject.meshAnimals-
dc.subject.meshChromosome Banding-
dc.subject.meshChromosome Mapping-
dc.subject.meshDNA-Binding Proteins-
dc.subject.meshGenes-
dc.subject.meshIn Situ Hybridization-
dc.subject.meshKaryotyping-
dc.subject.meshMammals-
dc.subject.meshReptiles-
dc.subject.meshReptilian Proteins-
dc.subject.meshSex Determination (Analysis)-
dc.subject.meshSpecies Specificity-
dc.titleThe karyotype of Alligator mississippiensis, and chromosomal mapping of the ZFY/X homologue, Zfc.en
dc.typeArticleen
dc.contributor.departmentSchool of Biological Sciences, University of Manchester, UK.en
dc.identifier.journalChromosomaen

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