Spermatogenic and mutagenic damage after paternal exposure to systemic indium-114m.

2.50
Hdl Handle:
http://hdl.handle.net/10541/96084
Title:
Spermatogenic and mutagenic damage after paternal exposure to systemic indium-114m.
Authors:
Hoyes, Katherine P; Sharma, Harbans L; Jackson, H; Hendry, Jolyon H; Morris, Ian D
Abstract:
The cytotoxic and mutagenic consequences of systemic administration of 114mIn have been examined. Adult male rats were dosed intraperitoneally with 14.8 or 3.7 MBq/kg 114mIn. Approximately 0.25% of the injected radioactivity was localized within the testis by 24 h and was retained with an effective half-life of 49.5 days. Breeding studies were started 3 days after injection, males being housed with two females for seven consecutive mating trials of 19 days, separated by 2 days. Indium-114m caused a reduction in litter size and an increase in the incidence of pre- and postimplantation losses and dominant lethal mutations. These effects became evident from 24 days but were most marked between 87-126 days after treatment and persisted up to 147 days. When animals were mated 200 days after treatment, no significant changes were observed. In a parallel study, administration of 14.8 MBq/kg 114mIn resulted in decreased testis and epididymal weight and sperm reserves. Maximal reduction occurred between 87-108 days after injection followed by recovery toward control values, but neither organ had reached normal levels at 200 days. A single dose of 3.7 MBq/kg, however, had no effect on reproductive organ weight or sperm content. Male F1 progeny from the 14.8 MBq/kg group of the second mating period (commencing at 24 days) displayed decreased testis weights and sperm content and provoked a higher incidence of dominant lethal mutations. This effect was not observed in male progeny from any other time or the alternative dose level.
Affiliation:
Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Manchester, United Kingdom.
Citation:
Spermatogenic and mutagenic damage after paternal exposure to systemic indium-114m. 1994, 139 (2):185-93 Radiat. Res.
Journal:
Radiation Research
Issue Date:
Aug-1994
URI:
http://hdl.handle.net/10541/96084
PubMed ID:
8052694
Type:
Article
Language:
en
ISSN:
0033-7587
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHoyes, Katherine Pen
dc.contributor.authorSharma, Harbans Len
dc.contributor.authorJackson, Hen
dc.contributor.authorHendry, Jolyon Hen
dc.contributor.authorMorris, Ian Den
dc.date.accessioned2010-04-09T09:14:05Z-
dc.date.available2010-04-09T09:14:05Z-
dc.date.issued1994-08-
dc.identifier.citationSpermatogenic and mutagenic damage after paternal exposure to systemic indium-114m. 1994, 139 (2):185-93 Radiat. Res.en
dc.identifier.issn0033-7587-
dc.identifier.pmid8052694-
dc.identifier.urihttp://hdl.handle.net/10541/96084-
dc.description.abstractThe cytotoxic and mutagenic consequences of systemic administration of 114mIn have been examined. Adult male rats were dosed intraperitoneally with 14.8 or 3.7 MBq/kg 114mIn. Approximately 0.25% of the injected radioactivity was localized within the testis by 24 h and was retained with an effective half-life of 49.5 days. Breeding studies were started 3 days after injection, males being housed with two females for seven consecutive mating trials of 19 days, separated by 2 days. Indium-114m caused a reduction in litter size and an increase in the incidence of pre- and postimplantation losses and dominant lethal mutations. These effects became evident from 24 days but were most marked between 87-126 days after treatment and persisted up to 147 days. When animals were mated 200 days after treatment, no significant changes were observed. In a parallel study, administration of 14.8 MBq/kg 114mIn resulted in decreased testis and epididymal weight and sperm reserves. Maximal reduction occurred between 87-108 days after injection followed by recovery toward control values, but neither organ had reached normal levels at 200 days. A single dose of 3.7 MBq/kg, however, had no effect on reproductive organ weight or sperm content. Male F1 progeny from the 14.8 MBq/kg group of the second mating period (commencing at 24 days) displayed decreased testis weights and sperm content and provoked a higher incidence of dominant lethal mutations. This effect was not observed in male progeny from any other time or the alternative dose level.en
dc.language.isoenen
dc.subject.meshAnimals-
dc.subject.meshBody Weight-
dc.subject.meshIndium Radioisotopes-
dc.subject.meshInfertility, Male-
dc.subject.meshLitter Size-
dc.subject.meshMale-
dc.subject.meshMutation-
dc.subject.meshOrgan Size-
dc.subject.meshRadiation Dosage-
dc.subject.meshRats-
dc.subject.meshRats, Sprague-Dawley-
dc.subject.meshSpermatogenesis-
dc.subject.meshTestis-
dc.titleSpermatogenic and mutagenic damage after paternal exposure to systemic indium-114m.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Manchester, United Kingdom.en
dc.identifier.journalRadiation Researchen
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