2.50
Hdl Handle:
http://hdl.handle.net/10541/96083
Title:
Structural organisation and chromosomal mapping of the human Id-3 gene.
Authors:
Deed, Richard W; Hirose, Tohru; Mitchell, Erika L D; Santibanez-Koref, Mauro F; Norton, John D
Abstract:
The helix-loop-helix (HLH) family of transcription factors plays a central role in the regulation of cell growth, differentiation and tumourigenesis. Members of the Id (inhibitor of DNA binding) class of these nuclear proteins are able to heterodimerise with and thereby antagonise the functions of other transcription factors of this family. We report here on the genomic organisation of the human Id3 (HLH 1R21/heir1) gene. Comparison with the two other mammalian Id genes, Id1 and Id2, reveals a highly conserved protein coding gene organisation consistent with evolution from a common, ancestral Id-like gene. In addition, by using a yeast artificial chromosome (YAC) clone of Id3, we have fine-scale mapped the gene to chromosome band 1p36.1 by fluorescence in situ hybridisation (FISH) and, using the same FISH technique, we have detected heterogeneity in tumour-associated 1p36 chromosome translocations.
Affiliation:
CRC Department of Gene Regulation, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Structural organisation and chromosomal mapping of the human Id-3 gene. 1994, 151 (1-2):309-14 Gene
Journal:
Gene
Issue Date:
30-Dec-1994
URI:
http://hdl.handle.net/10541/96083
DOI:
10.1016/0378-1119(94)90676-9
PubMed ID:
7828896
Type:
Article
Language:
en
ISSN:
0378-1119
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorDeed, Richard Wen
dc.contributor.authorHirose, Tohruen
dc.contributor.authorMitchell, Erika L Den
dc.contributor.authorSantibanez-Koref, Mauro Fen
dc.contributor.authorNorton, John Den
dc.date.accessioned2010-04-09T09:08:11Z-
dc.date.available2010-04-09T09:08:11Z-
dc.date.issued1994-12-30-
dc.identifier.citationStructural organisation and chromosomal mapping of the human Id-3 gene. 1994, 151 (1-2):309-14 Geneen
dc.identifier.issn0378-1119-
dc.identifier.pmid7828896-
dc.identifier.doi10.1016/0378-1119(94)90676-9-
dc.identifier.urihttp://hdl.handle.net/10541/96083-
dc.description.abstractThe helix-loop-helix (HLH) family of transcription factors plays a central role in the regulation of cell growth, differentiation and tumourigenesis. Members of the Id (inhibitor of DNA binding) class of these nuclear proteins are able to heterodimerise with and thereby antagonise the functions of other transcription factors of this family. We report here on the genomic organisation of the human Id3 (HLH 1R21/heir1) gene. Comparison with the two other mammalian Id genes, Id1 and Id2, reveals a highly conserved protein coding gene organisation consistent with evolution from a common, ancestral Id-like gene. In addition, by using a yeast artificial chromosome (YAC) clone of Id3, we have fine-scale mapped the gene to chromosome band 1p36.1 by fluorescence in situ hybridisation (FISH) and, using the same FISH technique, we have detected heterogeneity in tumour-associated 1p36 chromosome translocations.en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectLung Canceren
dc.subjectCancer Proteinsen
dc.subjectCultured Tumour Cellsen
dc.subjectLeukaemiaen
dc.subject.meshAdenocarcinoma-
dc.subject.meshAmino Acid Sequence-
dc.subject.meshAnimals-
dc.subject.meshBase Sequence-
dc.subject.meshBreast Neoplasms-
dc.subject.meshChromosome Aberrations-
dc.subject.meshChromosome Mapping-
dc.subject.meshChromosomes, Human, Pair 1-
dc.subject.meshConsensus Sequence-
dc.subject.meshConserved Sequence-
dc.subject.meshEvolution-
dc.subject.meshHelix-Loop-Helix Motifs-
dc.subject.meshHumans-
dc.subject.meshIn Situ Hybridization, Fluorescence-
dc.subject.meshInhibitor of Differentiation Proteins-
dc.subject.meshLeukemia-
dc.subject.meshLung Neoplasms-
dc.subject.meshLymphocytes-
dc.subject.meshMammals-
dc.subject.meshMolecular Sequence Data-
dc.subject.meshNeoplasm Proteins-
dc.subject.meshRestriction Mapping-
dc.subject.meshSequence Homology, Amino Acid-
dc.subject.meshTranscription Factors-
dc.subject.meshTranslocation, Genetic-
dc.subject.meshTumor Cells, Cultured-
dc.titleStructural organisation and chromosomal mapping of the human Id-3 gene.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Gene Regulation, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalGeneen
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