Structural organisation and chromosomal mapping of the human Id-3 gene.
Affiliation
CRC Department of Gene Regulation, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.Issue Date
1994-12-30
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The helix-loop-helix (HLH) family of transcription factors plays a central role in the regulation of cell growth, differentiation and tumourigenesis. Members of the Id (inhibitor of DNA binding) class of these nuclear proteins are able to heterodimerise with and thereby antagonise the functions of other transcription factors of this family. We report here on the genomic organisation of the human Id3 (HLH 1R21/heir1) gene. Comparison with the two other mammalian Id genes, Id1 and Id2, reveals a highly conserved protein coding gene organisation consistent with evolution from a common, ancestral Id-like gene. In addition, by using a yeast artificial chromosome (YAC) clone of Id3, we have fine-scale mapped the gene to chromosome band 1p36.1 by fluorescence in situ hybridisation (FISH) and, using the same FISH technique, we have detected heterogeneity in tumour-associated 1p36 chromosome translocations.Citation
Structural organisation and chromosomal mapping of the human Id-3 gene. 1994, 151 (1-2):309-14 GeneJournal
GeneDOI
10.1016/0378-1119(94)90676-9PubMed ID
7828896Type
ArticleLanguage
enISSN
0378-1119ae974a485f413a2113503eed53cd6c53
10.1016/0378-1119(94)90676-9
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