2.50
Hdl Handle:
http://hdl.handle.net/10541/96080
Title:
Is tumor cell radiation resistance correlated with metastatic ability?
Authors:
Suit, H; Allam, A; Allalunis-Turner, J; Brock, W; Girinsky, T; Hill, S; Hunter, N; Milas, L; Pearcey, R; Peters, L; West, Catharine M L
Abstract:
Patients who experience local failure following radiation treatment of epithelial malignancies exhibit a substantially higher rate of distant metastasis than those patients who achieve permanent local control. This fact has raised concern that the local failure to control the primary/regional tumor may serve as a marker of a particularly malignant neoplasm, i.e., high metastatic activity and radiation resistance. If this were true, there would be no gains in survival by increasing the efficacy of treating the primary/regional disease because the new local controls would develop distant metastasis. To investigate this concept, the relationship between distant metastasis probability and tumor cell radiation resistance has been studied by examining laboratory and clinical data (in vitro and in vivo assays) from six collaborating centers. TCD50s (radiation dose which inactivates half of the irradiated tumors) and incidence of distant metastasis in mice with local control have been evaluated for 24 murine tumor systems. SF2s (surviving fraction after 2 Gy) were determined in vitro for cell lines from 8 human, 13 mouse, and 15 rat tumors/tumor sublines and the metastatic activity assessed after injection of the cells into syngeneic murine hosts and xenogenic hosts for the human tumors. SF2s of cells from carcinomas of the head/neck, cervix, and endometrium which were controlled locally by radiation +/- surgery from four centers were compared for those which did and those which did not metastasize. The total number of patients studied was 222. The cumulative distributions of SF2s of locally controlled tumors which did and did not metastasize were not different in each of the data sets. Similarly, there was no demonstrable relationship between TCD50s and metastatic frequency in local control mice. Furthermore, the SF2s of murine and human tumor cell lines did not track with metastatic activity. Radiation sensitivity of clinical and laboratory tumors did not correlate with metastatic activity in studies of data from six centers.
Affiliation:
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston 02114.
Citation:
Is tumor cell radiation resistance correlated with metastatic ability? 1994, 54 (7):1736-41 Cancer Res.
Journal:
Cancer Research
Issue Date:
1-Apr-1994
URI:
http://hdl.handle.net/10541/96080
PubMed ID:
8137288
Type:
Article
Language:
en
ISSN:
0008-5472
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorSuit, Hen
dc.contributor.authorAllam, Aen
dc.contributor.authorAllalunis-Turner, Jen
dc.contributor.authorBrock, Wen
dc.contributor.authorGirinsky, Ten
dc.contributor.authorHill, Sen
dc.contributor.authorHunter, Nen
dc.contributor.authorMilas, Len
dc.contributor.authorPearcey, Ren
dc.contributor.authorPeters, Len
dc.contributor.authorWest, Catharine M Len
dc.date.accessioned2010-04-09T08:35:52Z-
dc.date.available2010-04-09T08:35:52Z-
dc.date.issued1994-04-01-
dc.identifier.citationIs tumor cell radiation resistance correlated with metastatic ability? 1994, 54 (7):1736-41 Cancer Res.en
dc.identifier.issn0008-5472-
dc.identifier.pmid8137288-
dc.identifier.urihttp://hdl.handle.net/10541/96080-
dc.description.abstractPatients who experience local failure following radiation treatment of epithelial malignancies exhibit a substantially higher rate of distant metastasis than those patients who achieve permanent local control. This fact has raised concern that the local failure to control the primary/regional tumor may serve as a marker of a particularly malignant neoplasm, i.e., high metastatic activity and radiation resistance. If this were true, there would be no gains in survival by increasing the efficacy of treating the primary/regional disease because the new local controls would develop distant metastasis. To investigate this concept, the relationship between distant metastasis probability and tumor cell radiation resistance has been studied by examining laboratory and clinical data (in vitro and in vivo assays) from six collaborating centers. TCD50s (radiation dose which inactivates half of the irradiated tumors) and incidence of distant metastasis in mice with local control have been evaluated for 24 murine tumor systems. SF2s (surviving fraction after 2 Gy) were determined in vitro for cell lines from 8 human, 13 mouse, and 15 rat tumors/tumor sublines and the metastatic activity assessed after injection of the cells into syngeneic murine hosts and xenogenic hosts for the human tumors. SF2s of cells from carcinomas of the head/neck, cervix, and endometrium which were controlled locally by radiation +/- surgery from four centers were compared for those which did and those which did not metastasize. The total number of patients studied was 222. The cumulative distributions of SF2s of locally controlled tumors which did and did not metastasize were not different in each of the data sets. Similarly, there was no demonstrable relationship between TCD50s and metastatic frequency in local control mice. Furthermore, the SF2s of murine and human tumor cell lines did not track with metastatic activity. Radiation sensitivity of clinical and laboratory tumors did not correlate with metastatic activity in studies of data from six centers.en
dc.language.isoenen
dc.subjectEndometrial Canceren
dc.subjectHead and Neck Canceren
dc.subjectCanceren
dc.subjectCancer Metastasisen
dc.subjectExperimental Canceren
dc.subject.meshAnimals-
dc.subject.meshEndometrial Neoplasms-
dc.subject.meshFemale-
dc.subject.meshHead and Neck Neoplasms-
dc.subject.meshHumans-
dc.subject.meshMelanoma-
dc.subject.meshMice-
dc.subject.meshNeoplasm Metastasis-
dc.subject.meshNeoplasms-
dc.subject.meshNeoplasms, Experimental-
dc.subject.meshRats-
dc.subject.meshRats, Inbred F344-
dc.subject.meshTransplantation, Heterologous-
dc.subject.meshTransplantation, Isogeneic-
dc.subject.meshUterine Cervical Neoplasms-
dc.titleIs tumor cell radiation resistance correlated with metastatic ability?en
dc.typeArticleen
dc.contributor.departmentDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston 02114.en
dc.identifier.journalCancer Researchen
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