Serum levels of the TGF-beta receptor are increased in atherosclerosis.

2.50
Hdl Handle:
http://hdl.handle.net/10541/96015
Title:
Serum levels of the TGF-beta receptor are increased in atherosclerosis.
Authors:
Blann, A D; Wang, Ji Min; Wilson, P B; Kumar, Shant
Abstract:
Murine monoclonal antibody E9 recognises a transforming growth factor (TGF) beta receptor, which is expressed in increased amounts by activated endothelial cells. In order to examine the biological role of this molecule in atherosclerosis, we have measured levels of the TGF-beta receptor alongside those of two other endothelial cell products (von Willebrand factor and soluble E-selectin) in the serum of 55 patients with atherosclerosis (29 with ischaemic heart disease and 26 with peripheral vascular disease), and in a cohort of 26 age- and sex-matched asymptomatic controls. There were increased levels of the TGF-beta receptor (P = 0.0079) and von Willebrand factor (P = 0.0001), but not soluble E-selection in patients' serum relative to the controls. In multivariate analysis of the endothelial cell products against total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressures, age, sex and smoking, both the TGF-beta receptor and von Willebrand factor correlated with total cholesterol (Spearman's r = 0.37 and r = 0.35, respectively, both P < 0.001). Lack of a correlation with a coarse endothelial damage marker von Willebrand factor or soluble E-selectin (produced by immunologically stimulated endothelial cells) implies other mechanisms are responsible for increased levels of the TGF-beta receptor in serum of patients with atherosclerosis.
Affiliation:
Department of Surgery, University Hospital of South Manchester, Nell Lane, Didsbury, Manchester M20 8LR, UK.
Citation:
Serum levels of the TGF-beta receptor are increased in atherosclerosis. 1996, 120 (1-2):221-6 Atherosclerosis
Journal:
Atherosclerosis
Issue Date:
Feb-1996
URI:
http://hdl.handle.net/10541/96015
DOI:
10.1016/0021-9150(95)05713-7
PubMed ID:
8645363
Type:
Article
Language:
en
ISSN:
0021-9150
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorBlann, A Den
dc.contributor.authorWang, Ji Minen
dc.contributor.authorWilson, P Ben
dc.contributor.authorKumar, Shanten
dc.date.accessioned2010-04-08T13:52:25Z-
dc.date.available2010-04-08T13:52:25Z-
dc.date.issued1996-02-
dc.identifier.citationSerum levels of the TGF-beta receptor are increased in atherosclerosis. 1996, 120 (1-2):221-6 Atherosclerosisen
dc.identifier.issn0021-9150-
dc.identifier.pmid8645363-
dc.identifier.doi10.1016/0021-9150(95)05713-7-
dc.identifier.urihttp://hdl.handle.net/10541/96015-
dc.description.abstractMurine monoclonal antibody E9 recognises a transforming growth factor (TGF) beta receptor, which is expressed in increased amounts by activated endothelial cells. In order to examine the biological role of this molecule in atherosclerosis, we have measured levels of the TGF-beta receptor alongside those of two other endothelial cell products (von Willebrand factor and soluble E-selectin) in the serum of 55 patients with atherosclerosis (29 with ischaemic heart disease and 26 with peripheral vascular disease), and in a cohort of 26 age- and sex-matched asymptomatic controls. There were increased levels of the TGF-beta receptor (P = 0.0079) and von Willebrand factor (P = 0.0001), but not soluble E-selection in patients' serum relative to the controls. In multivariate analysis of the endothelial cell products against total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressures, age, sex and smoking, both the TGF-beta receptor and von Willebrand factor correlated with total cholesterol (Spearman's r = 0.37 and r = 0.35, respectively, both P < 0.001). Lack of a correlation with a coarse endothelial damage marker von Willebrand factor or soluble E-selectin (produced by immunologically stimulated endothelial cells) implies other mechanisms are responsible for increased levels of the TGF-beta receptor in serum of patients with atherosclerosis.en
dc.language.isoenen
dc.subject.meshAged-
dc.subject.meshAnimals-
dc.subject.meshAntibodies, Monoclonal-
dc.subject.meshArteriosclerosis-
dc.subject.meshBiological Markers-
dc.subject.meshBlood Pressure-
dc.subject.meshCholesterol-
dc.subject.meshE-Selectin-
dc.subject.meshEndothelium, Vascular-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshLipids-
dc.subject.meshMale-
dc.subject.meshMice-
dc.subject.meshMiddle Aged-
dc.subject.meshMyocardial Infarction-
dc.subject.meshMyocardial Ischemia-
dc.subject.meshPeripheral Vascular Diseases-
dc.subject.meshReceptors, Transforming Growth Factor beta-
dc.subject.meshRisk Factors-
dc.subject.meshSmoking-
dc.subject.meshvon Willebrand Factor-
dc.titleSerum levels of the TGF-beta receptor are increased in atherosclerosis.en
dc.typeArticleen
dc.contributor.departmentDepartment of Surgery, University Hospital of South Manchester, Nell Lane, Didsbury, Manchester M20 8LR, UK.en
dc.identifier.journalAtherosclerosisen

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