Malignant epithelial mesothelioma of the peritoneum: observations on a problem case.

2.50
Hdl Handle:
http://hdl.handle.net/10541/95996
Title:
Malignant epithelial mesothelioma of the peritoneum: observations on a problem case.
Authors:
Eyden, Brian P; Banik, S; Harris, Martin
Abstract:
A 71-year-old asbestos-exposed male with symptoms suggestive of asbestosis for the previous 8 years presented with abdominal distension and ascites. Clinically, a diagnosis of mesothelioma carcinoma was made. Light microscopy of an omental biopsy failed to advance the diagnosis: The tumor was a solid, papillary, and glandular neoplasm lacking mucin and hyaluronidase-sensitive Alcian blue staining material. Immunohistochemistry gave positive results for Ber-EP4, LeuM1, and CEA, markers, favoring carcinoma. Electron microscopy revealed processes in channels and lumina, which were long, slender, and uncoated with a length: diameter ratio of 19.7. A few possessed small rootlets. A glycocalyx and glycocalyceal bodies were not seen. Other features included tonofibrils, a basal lamina, and desmosomes. The patient died 3 months following the onset of abdominal symptoms. Autopsy findings included solid and papillary tumor throughout the peritoneum, but no intrinsic tumor of the gastrointestinal tract or elsewhere. Arriving at a final diagnosis was complicated by immunohistochemistry, which favored carcinoma, and ultrastructure, which suggested mesothelioma. Taking into account all lines of evidence, it was concluded that the tumor was probably a mesothelioma but one with some features developed to an extent more typical of carcinoma.
Affiliation:
Department of Histopathology, Christie Hospital National Health Service Trust, Manchester, UK.
Citation:
Malignant epithelial mesothelioma of the peritoneum: observations on a problem case., 20 (4):337-44 Ultrastruct Pathol
Journal:
Ultrastructural Pathology
Issue Date:
8-Apr-2010
URI:
http://hdl.handle.net/10541/95996
DOI:
10.3109/01913129609016334
PubMed ID:
8837340
Type:
Article
Language:
en
ISSN:
0191-3123
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorEyden, Brian Pen
dc.contributor.authorBanik, Sen
dc.contributor.authorHarris, Martinen
dc.date.accessioned2010-04-08T11:55:11Z-
dc.date.available2010-04-08T11:55:11Z-
dc.date.issued2010-04-08T11:55:11Z-
dc.identifier.citationMalignant epithelial mesothelioma of the peritoneum: observations on a problem case., 20 (4):337-44 Ultrastruct Patholen
dc.identifier.issn0191-3123-
dc.identifier.pmid8837340-
dc.identifier.doi10.3109/01913129609016334-
dc.identifier.urihttp://hdl.handle.net/10541/95996-
dc.description.abstractA 71-year-old asbestos-exposed male with symptoms suggestive of asbestosis for the previous 8 years presented with abdominal distension and ascites. Clinically, a diagnosis of mesothelioma carcinoma was made. Light microscopy of an omental biopsy failed to advance the diagnosis: The tumor was a solid, papillary, and glandular neoplasm lacking mucin and hyaluronidase-sensitive Alcian blue staining material. Immunohistochemistry gave positive results for Ber-EP4, LeuM1, and CEA, markers, favoring carcinoma. Electron microscopy revealed processes in channels and lumina, which were long, slender, and uncoated with a length: diameter ratio of 19.7. A few possessed small rootlets. A glycocalyx and glycocalyceal bodies were not seen. Other features included tonofibrils, a basal lamina, and desmosomes. The patient died 3 months following the onset of abdominal symptoms. Autopsy findings included solid and papillary tumor throughout the peritoneum, but no intrinsic tumor of the gastrointestinal tract or elsewhere. Arriving at a final diagnosis was complicated by immunohistochemistry, which favored carcinoma, and ultrastructure, which suggested mesothelioma. Taking into account all lines of evidence, it was concluded that the tumor was probably a mesothelioma but one with some features developed to an extent more typical of carcinoma.en
dc.language.isoenen
dc.subjectPeritoneal Canceren
dc.subject.meshAged-
dc.subject.meshBiological Markers-
dc.subject.meshCarcinoma-
dc.subject.meshDiagnosis, Differential-
dc.subject.meshFatal Outcome-
dc.subject.meshHumans-
dc.subject.meshImmunohistochemistry-
dc.subject.meshMale-
dc.subject.meshMesothelioma-
dc.subject.meshMicroscopy, Electron-
dc.subject.meshPeritoneal Neoplasms-
dc.titleMalignant epithelial mesothelioma of the peritoneum: observations on a problem case.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital National Health Service Trust, Manchester, UK.en
dc.identifier.journalUltrastructural Pathologyen
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