Prognostic factors for breast recurrence after conservative breast surgery and radiotherapy: results from a randomised trial.

2.50
Hdl Handle:
http://hdl.handle.net/10541/95987
Title:
Prognostic factors for breast recurrence after conservative breast surgery and radiotherapy: results from a randomised trial.
Authors:
Magee, Brian; Swindell, Ric; Harris, Martin; Banerjee, Saumitra S
Abstract:
Prognostic factors predicting for breast recurrence following breast conserving surgery and radiotherapy have been identified in a prospective randomised trial comparing two different radiotherapy techniques. The first used megavoltage radiation to encompass the whole breast and regional nodes (WF group). The second used an electron field directed to the tumour bed only (LF group). With a median follow up of 8 years survival in both groups was the same (72%). There was an increased rate of breast recurrence in the LF group: 25%, compared to the WF group: 13% (P = 0.00008), expressed in actuarial terms at 8 years. In a multivariate analysis of factors predicting for breast recurrence, once the difference in treatment technique is allowed for, only two factors were found to be significant: histological grade (P = 0.013) and lymphovascular invasion in the histological specimen (P = 0.037).
Affiliation:
Christie Hospital, Manchester, UK.
Citation:
Prognostic factors for breast recurrence after conservative breast surgery and radiotherapy: results from a randomised trial. 1996, 39 (3):223-7 Radiother Oncol
Journal:
Radiotherapy and Oncology
Issue Date:
Jun-1996
URI:
http://hdl.handle.net/10541/95987
DOI:
10.1016/0167-8140(96)01747-1
PubMed ID:
8783398
Type:
Article
Language:
en
ISSN:
0167-8140
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorMagee, Brianen
dc.contributor.authorSwindell, Ricen
dc.contributor.authorHarris, Martinen
dc.contributor.authorBanerjee, Saumitra Sen
dc.date.accessioned2010-04-08T11:02:06Z-
dc.date.available2010-04-08T11:02:06Z-
dc.date.issued1996-06-
dc.identifier.citationPrognostic factors for breast recurrence after conservative breast surgery and radiotherapy: results from a randomised trial. 1996, 39 (3):223-7 Radiother Oncolen
dc.identifier.issn0167-8140-
dc.identifier.pmid8783398-
dc.identifier.doi10.1016/0167-8140(96)01747-1-
dc.identifier.urihttp://hdl.handle.net/10541/95987-
dc.description.abstractPrognostic factors predicting for breast recurrence following breast conserving surgery and radiotherapy have been identified in a prospective randomised trial comparing two different radiotherapy techniques. The first used megavoltage radiation to encompass the whole breast and regional nodes (WF group). The second used an electron field directed to the tumour bed only (LF group). With a median follow up of 8 years survival in both groups was the same (72%). There was an increased rate of breast recurrence in the LF group: 25%, compared to the WF group: 13% (P = 0.00008), expressed in actuarial terms at 8 years. In a multivariate analysis of factors predicting for breast recurrence, once the difference in treatment technique is allowed for, only two factors were found to be significant: histological grade (P = 0.013) and lymphovascular invasion in the histological specimen (P = 0.037).en
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectCancer Recurrenceen
dc.subject.meshBreast Neoplasms-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIncidence-
dc.subject.meshMastectomy, Segmental-
dc.subject.meshMiddle Aged-
dc.subject.meshMultivariate Analysis-
dc.subject.meshNeoplasm Recurrence, Local-
dc.subject.meshPrognosis-
dc.subject.meshProspective Studies-
dc.subject.meshRadiotherapy Dosage-
dc.subject.meshRadiotherapy, Adjuvant-
dc.subject.meshRadiotherapy, High-Energy-
dc.subject.meshSurvival Rate-
dc.titlePrognostic factors for breast recurrence after conservative breast surgery and radiotherapy: results from a randomised trial.en
dc.typeArticleen
dc.contributor.departmentChristie Hospital, Manchester, UK.en
dc.identifier.journalRadiotherapy and Oncologyen

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