Long-term control of polycythemia rubra vera with recombinant alpha interferon.

2.50
Hdl Handle:
http://hdl.handle.net/10541/95937
Title:
Long-term control of polycythemia rubra vera with recombinant alpha interferon.
Authors:
Clemons, Mark; Williams, Y F; Goldman, J M; Barrett, A J
Abstract:
The natural history of PRV is characterized by a prolonged period of myeloproliferation chiefly affecting the red cell series. It can be controlled by venesection and cytotoxic agents. In this case report the patient declined further 'standard' chemotherapy to control his disease and the use of relatively low doses of IFN-a was successful in our patient in controlling myeloproliferation and stabilizing the disease over a prolonged period. These results support the use of IFN-a, not only as a means of myelosuppression in PRV but also as an agent with the potential to prevent disease progression.
Affiliation:
Department of Haematology, Hammersmith Hospital, London, UK.
Citation:
Long-term control of polycythemia rubra vera with recombinant alpha interferon. 1996, 14 (1):37-40 Hematol Oncol
Journal:
Hematological oncology
Issue Date:
Mar-1996
URI:
http://hdl.handle.net/10541/95937
DOI:
10.1002/(SICI)1099-1069(199603)14:1<37::AID-HON564>3.0.CO;2-F
PubMed ID:
8613135
Type:
Article
Language:
en
ISSN:
0278-0232
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorClemons, Marken
dc.contributor.authorWilliams, Y Fen
dc.contributor.authorGoldman, J Men
dc.contributor.authorBarrett, A Jen
dc.date.accessioned2010-04-07T15:47:37Z-
dc.date.available2010-04-07T15:47:37Z-
dc.date.issued1996-03-
dc.identifier.citationLong-term control of polycythemia rubra vera with recombinant alpha interferon. 1996, 14 (1):37-40 Hematol Oncolen
dc.identifier.issn0278-0232-
dc.identifier.pmid8613135-
dc.identifier.doi10.1002/(SICI)1099-1069(199603)14:1<37::AID-HON564>3.0.CO;2-F-
dc.identifier.urihttp://hdl.handle.net/10541/95937-
dc.description.abstractThe natural history of PRV is characterized by a prolonged period of myeloproliferation chiefly affecting the red cell series. It can be controlled by venesection and cytotoxic agents. In this case report the patient declined further 'standard' chemotherapy to control his disease and the use of relatively low doses of IFN-a was successful in our patient in controlling myeloproliferation and stabilizing the disease over a prolonged period. These results support the use of IFN-a, not only as a means of myelosuppression in PRV but also as an agent with the potential to prevent disease progression.en
dc.language.isoenen
dc.subject.meshHumans-
dc.subject.meshInterferon Type I, Recombinant-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshPolycythemia Vera-
dc.subject.meshTime Factors-
dc.titleLong-term control of polycythemia rubra vera with recombinant alpha interferon.en
dc.typeArticleen
dc.contributor.departmentDepartment of Haematology, Hammersmith Hospital, London, UK.en
dc.identifier.journalHematological oncologyen

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