Increased serum lipoprotein(a) concentrations after growth hormone (GH) treatment in patients with isolated GH deficiency.

2.50
Hdl Handle:
http://hdl.handle.net/10541/95926
Title:
Increased serum lipoprotein(a) concentrations after growth hormone (GH) treatment in patients with isolated GH deficiency.
Authors:
O'Halloran, Domhnall J; Wieringa, Gilbert E; Tsatsoulis, Agathocles; Shalet, Stephen M
Abstract:
Fourteen post-pubertal subjects (11 male, 3 female) with isolated growth hormone (GH) deficiency were treated with a low dose (0.125 U/kg for the first 4 weeks and thereafter 0.25 U/kg/week) daily sc GH injection for 1 year. Fasting blood samples were collected at entry into the study and subsequently at 3 monthly intervals for estimation of serum cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol and lipoprotein(a) [Lp(a)]. Serum Lp(a) increased progressively during the treatment period (by analysis of variance) and was 41% higher at 12 months (P < 0.02) despite the fact that five patients showed little or no change. There was no significant change in any of the other lipid fractions. These observations are of concern as Lp(a) is an independent risk factor for cardiovascular disease and should introduce a cautionary note into the enthusiastic efforts to offer GH replacement to all GH deficient adults.
Affiliation:
Department of Endocrinology, Christie Hospital NHS Trust, Manchester, UK.
Citation:
Increased serum lipoprotein(a) concentrations after growth hormone (GH) treatment in patients with isolated GH deficiency. 1996, 33 ( Pt 4):330-4 Ann. Clin. Biochem.
Journal:
Annals of Clinical Biochemistry
Issue Date:
Jul-1996
URI:
http://hdl.handle.net/10541/95926
PubMed ID:
8836391
Type:
Article
Language:
en
ISSN:
0004-5632
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Halloran, Domhnall Jen
dc.contributor.authorWieringa, Gilbert Een
dc.contributor.authorTsatsoulis, Agathoclesen
dc.contributor.authorShalet, Stephen Men
dc.date.accessioned2010-04-07T15:57:52Z-
dc.date.available2010-04-07T15:57:52Z-
dc.date.issued1996-07-
dc.identifier.citationIncreased serum lipoprotein(a) concentrations after growth hormone (GH) treatment in patients with isolated GH deficiency. 1996, 33 ( Pt 4):330-4 Ann. Clin. Biochem.en
dc.identifier.issn0004-5632-
dc.identifier.pmid8836391-
dc.identifier.urihttp://hdl.handle.net/10541/95926-
dc.description.abstractFourteen post-pubertal subjects (11 male, 3 female) with isolated growth hormone (GH) deficiency were treated with a low dose (0.125 U/kg for the first 4 weeks and thereafter 0.25 U/kg/week) daily sc GH injection for 1 year. Fasting blood samples were collected at entry into the study and subsequently at 3 monthly intervals for estimation of serum cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol and lipoprotein(a) [Lp(a)]. Serum Lp(a) increased progressively during the treatment period (by analysis of variance) and was 41% higher at 12 months (P < 0.02) despite the fact that five patients showed little or no change. There was no significant change in any of the other lipid fractions. These observations are of concern as Lp(a) is an independent risk factor for cardiovascular disease and should introduce a cautionary note into the enthusiastic efforts to offer GH replacement to all GH deficient adults.en
dc.language.isoenen
dc.subjectCanceren
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshCohort Studies-
dc.subject.meshFemale-
dc.subject.meshGrowth Hormone-
dc.subject.meshHumans-
dc.subject.meshLipoprotein(a)-
dc.subject.meshMale-
dc.subject.meshNeoplasms-
dc.titleIncreased serum lipoprotein(a) concentrations after growth hormone (GH) treatment in patients with isolated GH deficiency.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalAnnals of Clinical Biochemistryen
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