2.50
Hdl Handle:
http://hdl.handle.net/10541/95925
Title:
Intranodal myofibroblastoma: report of a case.
Authors:
Eyden, Brian P; Harris, Martin; Greywoode, G I; Christensen, L; Banerjee, Saumitra S
Abstract:
Palisaded myofibroblastoma (hemorrhagic spindle cell tumor) is a recent addition to the group of benign primary spindle cell lesions of lymph nodes. These tumors are characterized histologically by hemorrhage, palisading, and foci of collagen called amianthoid fibers. We report a further typical example with the aim of discussing its differentiation. Tumor cells were positive for smooth-muscle actin and vimentin. The cytoplasm contained moderate numbers of rough endoplasmic reticulum cisternae and some smooth-muscle type myofilaments. Subplasmalemmal densities and plasmalemmal caveolae, as well as material interpreted as external lamina, were identified at the cell surface, whereas the fibronexus junctions typical of myofibroblasts were not seen. Immunostaining for type IV collagen was positive. Intranodal myofibroblastomas have largely been considered as myofibroblastic, but the observations presented here raise the alternative possibility of simple smooth-muscle differentiation. The foci of collagen widely referred to as amianthoid fibers contained fibrils mostly of conventional diameter, 50-83 nm. The giant collagen fibrils typical of true amianthoid change were absent. It is suggested that the term amianthoid be used only after ultrastructural confirmation of the presence of giant collagen fibrils.
Affiliation:
Department of Histopathology, Christie Hospital National Health Service Trust, Manchester, United Kingdom.
Citation:
Intranodal myofibroblastoma: report of a case., 20 (1):79-88 Ultrastruct Pathol
Journal:
Ultrastructural Pathology
Issue Date:
1996
URI:
http://hdl.handle.net/10541/95925
DOI:
10.3109/01913129609023242
PubMed ID:
8789214
Type:
Article
Language:
en
ISSN:
0191-3123
Appears in Collections:
All Christie Publications

Full metadata record

DC FieldValue Language
dc.contributor.authorEyden, Brian Pen
dc.contributor.authorHarris, Martinen
dc.contributor.authorGreywoode, G Ien
dc.contributor.authorChristensen, Len
dc.contributor.authorBanerjee, Saumitra Sen
dc.date.accessioned2010-04-07T15:56:30Z-
dc.date.available2010-04-07T15:56:30Z-
dc.date.issued1996-
dc.identifier.citationIntranodal myofibroblastoma: report of a case., 20 (1):79-88 Ultrastruct Patholen
dc.identifier.issn0191-3123-
dc.identifier.pmid8789214-
dc.identifier.doi10.3109/01913129609023242-
dc.identifier.urihttp://hdl.handle.net/10541/95925-
dc.description.abstractPalisaded myofibroblastoma (hemorrhagic spindle cell tumor) is a recent addition to the group of benign primary spindle cell lesions of lymph nodes. These tumors are characterized histologically by hemorrhage, palisading, and foci of collagen called amianthoid fibers. We report a further typical example with the aim of discussing its differentiation. Tumor cells were positive for smooth-muscle actin and vimentin. The cytoplasm contained moderate numbers of rough endoplasmic reticulum cisternae and some smooth-muscle type myofilaments. Subplasmalemmal densities and plasmalemmal caveolae, as well as material interpreted as external lamina, were identified at the cell surface, whereas the fibronexus junctions typical of myofibroblasts were not seen. Immunostaining for type IV collagen was positive. Intranodal myofibroblastomas have largely been considered as myofibroblastic, but the observations presented here raise the alternative possibility of simple smooth-muscle differentiation. The foci of collagen widely referred to as amianthoid fibers contained fibrils mostly of conventional diameter, 50-83 nm. The giant collagen fibrils typical of true amianthoid change were absent. It is suggested that the term amianthoid be used only after ultrastructural confirmation of the presence of giant collagen fibrils.en
dc.language.isoenen
dc.subjectMuscle Tissue Canceren
dc.subject.meshHumans-
dc.subject.meshLymph Nodes-
dc.subject.meshLymphatic Diseases-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoplasms, Muscle Tissue-
dc.titleIntranodal myofibroblastoma: report of a case.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital National Health Service Trust, Manchester, United Kingdom.en
dc.identifier.journalUltrastructural Pathologyen

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