2.50
Hdl Handle:
http://hdl.handle.net/10541/95847
Title:
Novel asymmetric photosensitizers: an in vitro study.
Authors:
Haylett, Ann K; Forbes, E; MacLennan, A; Truscott, T G; Moore, James V
Abstract:
A series of compounds based on an asymmetrical protoporphyrin molecule have been examined. The paired groups of sensitizers differed in terms of the presence or absence of a permanent positive charge, in the alkyl side chain length and in having either a primary or secondary amine substituent. The effects of these variables on drug uptake, partition coefficient and photodynamic cell kill were tested. Drug uptake and partition coefficient were shown to be correlated. Differences in gross uptake were found within paired groups of sensitizers although cell-associated uptake alone did not correlate with clonogenic cell survival. Of the compounds tested it was the sensitizers with alkyl side chains, rather than the permanently positively charged compounds, which resulted in the greatest degree of clonogenic cell kill.
Affiliation:
Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Manchester, UK.
Citation:
Novel asymmetric photosensitizers: an in vitro study. 1996, 105 (2):187-93 Cancer Lett.
Journal:
Cancer Letters
Issue Date:
2-Aug-1996
URI:
http://hdl.handle.net/10541/95847
DOI:
10.1016/0304-3835(96)04279-6
PubMed ID:
8697443
Type:
Article
Language:
en
ISSN:
0304-3835
Appears in Collections:
All Paterson Institute for Cancer Research

Full metadata record

DC FieldValue Language
dc.contributor.authorHaylett, Ann Ken
dc.contributor.authorForbes, Een
dc.contributor.authorMacLennan, Aen
dc.contributor.authorTruscott, T Gen
dc.contributor.authorMoore, James Ven
dc.date.accessioned2010-04-07T10:48:19Z-
dc.date.available2010-04-07T10:48:19Z-
dc.date.issued1996-08-02-
dc.identifier.citationNovel asymmetric photosensitizers: an in vitro study. 1996, 105 (2):187-93 Cancer Lett.en
dc.identifier.issn0304-3835-
dc.identifier.pmid8697443-
dc.identifier.doi10.1016/0304-3835(96)04279-6-
dc.identifier.urihttp://hdl.handle.net/10541/95847-
dc.description.abstractA series of compounds based on an asymmetrical protoporphyrin molecule have been examined. The paired groups of sensitizers differed in terms of the presence or absence of a permanent positive charge, in the alkyl side chain length and in having either a primary or secondary amine substituent. The effects of these variables on drug uptake, partition coefficient and photodynamic cell kill were tested. Drug uptake and partition coefficient were shown to be correlated. Differences in gross uptake were found within paired groups of sensitizers although cell-associated uptake alone did not correlate with clonogenic cell survival. Of the compounds tested it was the sensitizers with alkyl side chains, rather than the permanently positively charged compounds, which resulted in the greatest degree of clonogenic cell kill.en
dc.language.isoenen
dc.subjectSkin Canceren
dc.subjectCultured Tumour Cellsen
dc.subject.meshCell Survival-
dc.subject.meshHumans-
dc.subject.meshLethal Dose 50-
dc.subject.meshLight-
dc.subject.meshMelanoma-
dc.subject.meshPermeability-
dc.subject.meshPhotosensitizing Agents-
dc.subject.meshSkin Neoplasms-
dc.subject.meshTumor Cells, Cultured-
dc.titleNovel asymmetric photosensitizers: an in vitro study.en
dc.typeArticleen
dc.contributor.departmentDepartment of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Manchester, UK.en
dc.identifier.journalCancer Lettersen

Related articles on PubMed

All Items in Christie are protected by copyright, with all rights reserved, unless otherwise indicated.